Inflammatory changes upon a single maximal exercise test in depressed patients and healthy controls

Boettger, Silke; Müller, Hans-Josef; Oswald, K.; Puta, Christian; Donath, Lars; Gabriel, Holger; Bär, Karl‐Jürgen

doi:10.1016/j.pnpbp.2010.01.016

Cited by 17 publications

(4 citation statements)

References 27 publications

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“…NS post-treatment changes in serum IL-6 levels from baseline [195] MDD (n = 18), HC (n = 18) Both on exercise challenge Plasma IL-6 levels increased post-exercise [196] [197] [119] MDD + amitriptyline (n = 24), HC (n = 15) Pretreatment IL-6 levels were lower in drug responders and higher in drug nonresponders versus HC…”

Section: Optimization Of Anti-il-6 Treatment Approaches In Mdd Via Sementioning

confidence: 99%

Novel investigational drugs targeting IL-6 signaling for the treatment of depression

Fonseka

McIntyre

Soczynska

et al. 2015

Expert Opinion on Investigational Drugs

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To improve drug development for the treatment of MDD, there is a critical need to identify promising targets. Target identification will require guidance from a strategic framework such as The Research Domain Criteria, and convincing evidence relating known targets to brain function under both physiological and pathological conditions. Although current evidence provides rationale for administering anti-IL-6 treatments in MDD, further studies confirming safety, target affinity and therapeutic benefits are warranted.

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Section: Optimization Of Anti-il-6 Treatment Approaches In Mdd Via Sementioning

confidence: 99%

Novel investigational drugs targeting IL-6 signaling for the treatment of depression

Fonseka

McIntyre

Soczynska

et al. 2015

Expert Opinion on Investigational Drugs

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“…We found only six clinical trials (Table 1) investigating the effect of physical exercise as an add-on to antidepressant drug therapy on inflammatory markers in MDD [15,[79][80][81][82][83]. The exercise component was variable, ranging from 15-min exhaustive aerobic activities, strength exercise, to Tai Chi.…”

Section: Effect Of the Combination Of Antidepressant Drugs And Exercise On Inflammatory Markers In Mdd Patientsmentioning

confidence: 99%

Effects of antidepressant drug therapy with or without physical exercise on inflammatory biomarkers in major depressive disorder: a systematic review and meta-analysis of randomized controlled trials

Fernandes

Scotti-Muzzi

Soeiro-de-Souza

2021

Eur J Clin Pharmacol

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Objective To conduct a systematic review and meta-analysis of the effects of antidepressant drug therapy (with or without physical exercise) on peripheral inflammatory markers in patients with major depressive disorder (MDD). Methods MEDLINE, PyscINFO, Embase, and Google Scholar databases were searched until May 2020. Randomized trials that measured at least one inflammatory biomarker and included adult outpatients with MDD under antidepressant drug therapy (any drug) with or without physical exercise (any modality) were eligible. Results were summarized using the standardized mean difference (SMD) with 95% confidence intervals (95% CI) under a random-effects model. The Cochrane risk of bias tool (2010) was used to evaluate the risk of bias in the included trials. Results Sixty-three trials were identified, encompassing data from 3482 patients, and 20 investigated biomarkers. Trials had biases across multiple domains, rising concerns primarily to selection bias/performance bias/detection bias/attrition bias. SMDs between pre-and post-results indicated a significant reduction in the levels of IL-2 (SMD, − 0.25; 95% CI, − 0.41 to − 0.09, P = 0.002), IL-6 (SMD, − 0.19; 95% CI, − 0.35 to − 0.025, P = 0.024), IL-10 (SMD, − 0.32; 95% CI, − 0.57 to − 0.07, P = 0.011), and serum cortisol (SMD, − 0.35; 95% CI, − 0.58 to − 0.12, P = 0.002). Evidence supporting the influence of physical exercise combined with antidepressant drugs on peripheral inflammatory markers in MDD is sparse and heterogeneous. Conclusion There is some evidence that antidepressant drug therapy is associated with an overall positive reduction in inflammatory markers, but the evidence is heterogeneous. Further research linking how inflammatory biomarkers modulate physiology related to antidepressant response is required.

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“…The plasma concentration of the pro-inflammatory cytokines (e.g. TNF-α, IL-1β, IL-6 and IFN-γ) as well as acute-phase proteins increase (Boettger et al 2010;Castellano et al 2008). However, the degree of immune activation is reported to decrease in persons that perform regular training (Simpson et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Increased level of circulating cell-free mitochondrial DNA due to a single bout of strenuous physical exercise

et al. 2020

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Purpose Physical exercise is reported to affect the immune response in various ways. Thus, the levels of pro-inflammatory cytokines as well as the abundance of circulating leukocytes are changed. In this study, the occurence of circulating cell-free mitochondrial DNA (cfmtDNA) and nuclear DNA (nDNA) was investigated in connection with a single bout of strenuous physical exercise. Methods Healthy volunteers performed a controlled ergo-spirometry cycle test and venous blood samples were taken at different time-points to analyze the concentration of blood components before, during and after the test. The number of circulating leukocytes was measured, as well as secretion of the soluble urokinase activator receptor (suPAR). Results Cf-mtDNA significantly increased during exercise, compared to baseline values and after 30 and 90 min of rest. Circulating leukocytes increased during exercise, but returned to baseline levels afterwards. Surface expression of the urokinase plasminogen activating receptor (uPAR) on neutrophils decreased significantly during exercise. The concentration of suPAR tended to increase during exercise but only significantly after 90 min of rest. Conclusion Increased concentration of cf-mtDNA indicates that cell damage takes place during high intensity training. Hypoxia and tissue damage are likely causes of cf-mtDNA from muscle cells. The levels of cf-mtDNA remain high during the initial rest, due to the decreasing numbers of leukocytes normally clearing the plasma from cf-mtDNA. The increased levels of suPAR further emphasize that strenuous physical exercise causes a reaction similar to inflammation. Further studies are needed to detect the source of increased cf-mtDNA and the corresponding increase of suPAR liberation. Keywords Cell-free mitochondrial DNA • Exercise • Inflammatory response • Leukocytes • Soluble urokinase plasminogen activator receptor Abbreviations ATP Adenosine-tri-phosphate β2M Beta-2 microglobulin BSA Bovine serum albumin cf-mtNDA Cell-free mitochondrial DNA cf-nDNA Cell-free nuclear DNA

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Inflammatory changes upon a single maximal exercise test in depressed patients and healthy controls

Cited by 17 publications

References 27 publications

Novel investigational drugs targeting IL-6 signaling for the treatment of depression

Novel investigational drugs targeting IL-6 signaling for the treatment of depression

Effects of antidepressant drug therapy with or without physical exercise on inflammatory biomarkers in major depressive disorder: a systematic review and meta-analysis of randomized controlled trials

Increased level of circulating cell-free mitochondrial DNA due to a single bout of strenuous physical exercise

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