2024
DOI: 10.3390/jcm13041092
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Inflammatory Complications in Chronic Granulomatous Disease

Alexandros Grammatikos,
Andrew R. Gennery

Abstract: Chronic granulomatous disease (CGD) is a rare inborn error of immunity that typically manifests with infectious complications. As the name suggest though, inflammatory complications are also common, often affecting the gastrointestinal, respiratory, urinary tracts and other tissues. These can be seen in all various types of CGD, from X-linked and autosomal recessive to X-linked carriers. The pathogenetic mechanisms underlying these complications are not well understood, but are likely multi-factorial and refle… Show more

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Cited by 7 publications
(1 citation statement)
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“…Management strategies involve antibacterial prophylaxis with trimethoprim-sulfamethoxazole, antifungal prophylaxis, typically with itraconazole, and interferon gamma immunotherapy to reduce infection risk. Hematopoietic stem cell transplantation (HCT) is the preferred treatment for CGD, offering successful outcomes [91][92][93][94] .…”
Section: Chronic Granulomatous Disease (Cgd)mentioning
confidence: 99%
“…Management strategies involve antibacterial prophylaxis with trimethoprim-sulfamethoxazole, antifungal prophylaxis, typically with itraconazole, and interferon gamma immunotherapy to reduce infection risk. Hematopoietic stem cell transplantation (HCT) is the preferred treatment for CGD, offering successful outcomes [91][92][93][94] .…”
Section: Chronic Granulomatous Disease (Cgd)mentioning
confidence: 99%