Inflammatory cytokines and oxidative stress biomarkers in irritable bowel syndrome: Association with digestive symptoms and quality of life

Choghakhori, Razieh; Abbasnezhad, Amir; Hasanvand, Amin; Amani, Reza

doi:10.1016/j.cyto.2017.05.005

Cited by 122 publications

(113 citation statements)

References 33 publications

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“…Similarly, total anti-oxidant capacity was found to be significantly lower in patients with IBS patients compared to healthy controls in one recent study. 16 Findings of higher TOS and OSI and lower TAS in IBS patients in this study are in accordance to study by Karakas et al 17 Additional finding from our study is patients with diarrhea predominant IBS have higher TOS/OSI and lower TAS as compared to patients who have purely constipation or have mixed symptoms of diarrhea and constipation. Another finding of this study that SPA though was significantly higher in IBS patients than controls, only patients with mixed symptoms (IBS-M) have significant elevation in SPA between the subgroups (P<0.001) [ when compared to IBS-D, IBS-C and controls on subgroup analysis.…”

Section: Discussionsupporting

confidence: 92%

“…Examples include genetic studies showing reduced levels of IL-10 expression, findings of increased ratio of pro-to anti-inflammatory cytokines (i.e., IL-10 to IL-12) 13 , increased production of pro-inflammatory cytokines (e.g., IL-1β, IL-6, and TNF-α) from peripheral blood mononuclear cells (PBMCs) 14 and increased numbers of activated T cells in the peripheral blood of patients with IBS compared to controls. A number of markers of inflammation has been studied in patients with IBS including hsCRP (high sensitive c-reactive protein) 15 , tumor necrosis factor alpha (TNF-alpha), IL-17, IL-10, malondialdehyde (MDA), total anti-oxidant capacity 16 , total oxidant status, total anti-oxidant status, serum prolidase activity 17,18 and many others.…”

Section: Introductionmentioning

confidence: 99%

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A Study on the Role of Oxidative Stress and Prolidase Enzyme in the Clinical Evaluation of Irritable Bowel Syndrome (IBS)

Chaturvedi¹,

Srivastava²,

Shukla³

et al. 2020

IJCMR

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Introduction: Irritable bowel syndrome (IBS), though a benign disorder is highly prevalent and imposes high cost and substantial morbidity upon general population. Long considered as functional disorder, IBS pathogenesis carries an organic basis at least in a subset of patients. Altered intestinal immune response and low grade intestinal inflammation have been confirmed as pathophysiology of IBS in few studies. Oxidative stress indicates that there is inflammation and, markers of oxidative stress may be developed as diagnostic tool for IBS in future. Study aimed to evaluate oxidative stress in form of total oxidant status (TOS), total anti-oxidant status (TAS), oxidative stress index (OSI) and serum prolidase activity (SPA) as a marker of intestinal inflammation in IBS patients and healthy controls. Material and methods: In this case -control study done at a teaching medical institute in north India over a period of one year, 120 IBS patients (cases) and 40 healthy volunteers (controls) were evaluated for TOS, TAS, OSI and SPA. Patients with IBS were sub-divided into 3 groups (40 each): diarrhea predominant, constipation predominant and mixed type (IBS-D, C and M respectively). Student t-test, chi-square test and ANOVA tests were used for statistical analysis. Results: Mean TOS, TOS/TAS (OSI) and prolidase levels were significantly higher in IBS group than control with p value of <0.001,< 0.001, and <0.01 respectively. Level of TOS was highest in IBS-D subgroup followed by IBS-M and Lowest in IBS-C subgroup showing a significant difference between IBS-D and IBS-C, IBS-D and IBS-M and IBS-M and IBS-C with p values <0.001 for each comparison. OSI was highest in IBS-D and lowest in IBS-C with significant differences between the subgroups (P<0.001). Only IBS-M subgroup had significantly higher serum prolidase activity when compared to controls (p<0.001) IBS-D (P=0.013) and IBS-C (P=0.01). TAS level was significantly higher in controls (P<0.001) than cases. There were significant differences between all four subgroups (p<0.001) except between IBS-C and IBS-M subgroups (P=0.294). Conclusion: This study observed that there is increased oxidative stress and decreased antioxidant capacity in patient with IBS. To support our results further prospective and randomized controlled trials are necessary.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

A Study on the Role of Oxidative Stress and Prolidase Enzyme in the Clinical Evaluation of Irritable Bowel Syndrome (IBS)

Chaturvedi¹,

Srivastava²,

Shukla³

et al. 2020

IJCMR

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“…Firstly, it is uncertain whether cognitive impairments are better accounted for by pathophysiological processes of present IBS illness activity, or by its chronicity, which may reflect accumulated neurobiological disruptions such as oxidative stress and inflammation. 13 Secondly, apart from a study identifying hippocampal-mediated visuospatial memory impairment in IBS independently of psychiatric comorbidity, 14 the extant other kinds of cognitive alterations are attributable to comorbid anxiety and depressive disorders have remained unclear. 15,16 Thirdly, extant cognitive studies did not specify or compare patients according to their IBS subtypes.…”

Section: Introductionmentioning

confidence: 99%

Nature and specificity of altered cognitive functioning in IBS

Wong

Mak

Yuen

et al. 2019

Neurogastroenterology Motil

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Background It is unknown whether cognitive dysfunction found in patients with irritable bowel syndrome (IBS) was attributable to the different subtypes, ongoing pathophysiological processes, trait characteristics, or psychiatric comorbidity. Methods Forty Rome‐III patients with IBS (20 diarrhea‐predominant [IBS‐D] and 20 constipation‐predominant [IBS‐C]) and 40 age‐, sex‐, education‐matched healthy controls were systematically recruited and compared on their cognitive function with continuous performance test (CPT), Wisconsin Card Sorting Test (WCST) and emotional Stroop test. Beck Anxiety Inventory (BAI), Beck Depression Inventory‐II (BDI‐II), Patient Health Questionnaire‐15 (PHQ‐15) and a structured bowel symptom questionnaire were performed to measure anxiety, depressive, somatization, and bowel symptoms, respectively. Psychiatric diagnoses were ascertained with SCID‐I (Structured Clinical Interview for DSM‐IV Axis I Disorders). Key Results Patients with IBS showed significantly increased standard deviation of reaction time (SDRT) (P = .003) on CPT, increased failure to maintain set (FMS) (P=.002), and percentage of perseverative errors (P = .003) on WCST. SDRT did not correlate with illness chronicity or bowel symptoms. FMS correlated with bowel symptom severity. In logistic regression models controlled for BAI, BDI‐II, and PHQ‐15, SDRT (AOR = 1.08, P = .025), but not FMS (P = .25) or percentage of perseverative errors (P = .24), significantly differentiated IBS from controls. Cognitive function was not significantly different between IBS‐C and IBS‐D (P > .05), or between pure IBS (n = 22) and IBS with generalized anxiety disorder (GAD) (n = 17) (P > .05). Conclusions & Inferences Patients with IBS showed attentional and executive function impairment irrespective of subtypes but otherwise heterogeneous in terms of its state‐trait correlations and overlap with anxiety comorbidity.

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“…For example, R. Choghakhori et al found that compared with HCs, patients with IBS-D showed significantly higher TNF-α and IL-17. 48 Yang B and Chen J found that the expression levels of interferon-γ, IL-1β, IL-17, and IL-12 in the intestinal tissues of PI-IBS mouse models are significantly higher than those of control mice and that the expression levels of IL-10 and IL-4 are significantly decreased. 35 Arjuna P provided evidence for subclinical intestinal mucosal inflammation in patients with IBS-D in a tropical setting.…”

Section: Discussionmentioning

confidence: 99%

“…For example, R. Choghakhori et al found that compared with HCs, patients with IBS-D showed significantly higher TNF-α and IL-17 48. A, D-I, PRDX1 was strongly expressed in IBS patients, especially in patients with PI-IBS and IBS-D from the staining and the IOD value, whereas healthy colonic mucosa only showed a weak expression of PRDX1 (F = 5.359, P < .001).…”

mentioning

confidence: 98%

Peroxiredoxin 1 as an inflammatory marker in diarrhea‐predominant and postinfectious irritable bowel syndrome

et al. 2019

Neurogastroenterology Motil

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Background Low‐grade inflammation occurs in some patients with irritable bowel syndrome (IBS). However, the exact inflammatory markers of IBS and the relationship of these markers with IBS subtypes and symptoms are poorly defined. Peroxiredoxin 1 (PRDX1) plays an important role in inflammatory responses, including intestinal inflammation. We investigated whether PRDX1 is associated with the diagnosis, subtypes, and symptom severity of IBS. Methods A total of 177 IBS patients and 174 sex‐ and age‐matched healthy controls (HCs) were recruited. The PRDX1 levels in the sera and colonic mucosa of the participants were detected by enzyme‐linked immunosorbent assays and immunohistochemistry. The severity of IBS symptoms was assessed using the IBS Severity Scoring System (SSS) questionnaire. Results The PRDX1 levels in the sera (F = 71.81, P < .001) and colonic mucosa (F = 5.359, P < .001) of postinfectious (PI‐IBS) and diarrhea‐predominant IBS (IBS‐D) groups were significantly higher than those of the other three IBS subtypes and HC group. The PRDX1 level in the serum and colonic mucosa of IBS‐D (serum, P < .01, mucosa, P < .001) and PI‐IBS (serum, P < .05, mucosa, P < .001) groups with the most severe symptoms was significantly higher than that in the groups with mild and moderate symptoms. Correlation analysis revealed that in patients with IBS‐D (P < .001) and PI‐IBS (P < .05), the levels of PRDX1 and TNF‐α in sera had a significant positive correlation with IBS‐SSS. Conclusion Elevated PRDX1 in the serum and colon mucosa may be closely related to the progression of IBS (especially IBS‐D and PI‐IBS) and the expression of gastrointestinal symptoms.

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Inflammatory cytokines and oxidative stress biomarkers in irritable bowel syndrome: Association with digestive symptoms and quality of life

Cited by 122 publications

References 33 publications

A Study on the Role of Oxidative Stress and Prolidase Enzyme in the Clinical Evaluation of Irritable Bowel Syndrome (IBS)

A Study on the Role of Oxidative Stress and Prolidase Enzyme in the Clinical Evaluation of Irritable Bowel Syndrome (IBS)

Nature and specificity of altered cognitive functioning in IBS

Peroxiredoxin 1 as an inflammatory marker in diarrhea‐predominant and postinfectious irritable bowel syndrome

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