Inflammatory cytokines in BAL fluid and pulmonary hemodynamics in high-altitude pulmonary edema

Kubo, Keishi; Hanaoka, Masayuki; Hayano, Toshihide; Miyahara, Takashige; Hachiya, Tsutomu; Hayasaka, Muneharu; Koizumi, Tomonobu; Fujimoto, Keisaku; Kobayashi, Toshio; Honda, Takayuki

doi:10.1016/s0034-5687(98)00006-1

Cited by 139 publications

(94 citation statements)

References 29 publications

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“…Chest radiographs and computed tomography scans in symptomatic HAPE (figure 2) show a patchy peripheral and nodular distribution of oedema [54]. Bronchoalveolar lavage (BAL) shows a protein-rich exudate and mild alveolar haemorrhage, which initially is noninflammatory, but may progress after several days to a more inflammatory picture, as discussed later [55][56][57]. Echocardiographic and pulmonary artery catheterisation studies at high altitude show marked pulmonary hypertension [58][59][60].…”

Section: Hapementioning

confidence: 99%

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Acute high-altitude sickness

2017

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At any point 1-5 days following ascent to altitudes ⩾2500 m, individuals are at risk of developing one of three forms of acute altitude illness: acute mountain sickness, a syndrome of nonspecific symptoms including headache, lassitude, dizziness and nausea; high-altitude cerebral oedema, a potentially fatal illness characterised by ataxia, decreased consciousness and characteristic changes on magnetic resonance imaging; and high-altitude pulmonary oedema, a noncardiogenic form of pulmonary oedema resulting from excessive hypoxic pulmonary vasoconstriction which can be fatal if not recognised and treated promptly. This review provides detailed information about each of these important clinical entities. After reviewing the clinical features, epidemiology and current understanding of the pathophysiology of each disorder, we describe the current pharmacological and nonpharmacological approaches to the prevention and treatment of these diseases.

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Section: Hapementioning

confidence: 99%

“…The first measurements of alveolar lavage fluid in mountaineers [55,57] were obtained in those with established HAPE. In addition to the high protein concentrations, some, but not all cases had significant neutrophilia and elevations of pro-inflammatory cytokines and neutrophil chemotactic factors.…”

Section: Inflammationmentioning

confidence: 99%

Acute high-altitude sickness

2017

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“…Teleradiography shows diffuse alveolar images unevenly distributed 19,38,45 . The alveolar fluid is rich in proteins and inflammatory mediators 33,45,52,53 .…”

Section: Diseases Of Altitudementioning

confidence: 99%

Physical activity at moderate and high altitudes. Cardiovascular and respiratory morbidit

Campos¹,

Costa²

1999

Arq. Bras. Cardiol.

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“…However it is difficult to separate these effects from those of the anorexia that is induced by high altitude, the generally increased levels of physical exertion of people in field exercises at high altitude, and the extremes of temperature experienced at high altitude. Japanese investigators studying the mechanism of high-altitude pulmonary edema (HAPE) report significant elevations in many parameters of immune function, including IL-lß, IL-6 and 8, TNF-ct, IL-1 receptor agonist, total WBC count, neutrophils, macrophages, lymphocytes, and a number of proteins (Kubo et al, 1998). These changes are believed to be associated with the early stage of HAPE and possibly with pulmonary hypertension; however it is not clear how the ability of the immune system to respond to infectious agents is affected.…”

Section: Exposure To High Altitudementioning

confidence: 99%

Military Strategies for Sustainment of Nutrition and Immune Function in the Field

Poos¹,

Costello²,

Carlson-Newberry³

1999

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The serpent has been a symbol of long life, healing, and knowledge among almost all cultures and religions since the beginning of recorded history. The image adopted as a logotype by the Institute of Medicine is based on a relief carving from ancient Greece, now held by the Staatliche Museen in Berlin.Cover: Resting monocyte/macrophage being activated to produce proinflammatory cytokines which form complexes with receptor binding proteins. Adapted from COMMITTEE ON MILITARY NUTRITION RESEARCHROBERT O. NESHEIM (Chair, through June 30, 1998) (FNB), Institute of Medicine, National Academy of Sciences. Other workshops or symposia have included such topics as food components to enhance performance; nutritional needs in hot, cold, and high-altitude environments; body composition and physical performance; nutrition and physical performance; cognitive testing methodology; and fluid replacement and heat stress. These workshops form part of the response that the CMNR provides to the Commander, U. HISTORY OF THE COMMITTEEThe CMNR was established in October 1982 following a request by the Assistant Surgeon General of the Army that the Board on Military Supplies of the National Academy of Sciences set up a special committee. The purpose of this committee was to advise the U.S. Department of Defense on the need for and conduct of nutrition research and related issues. The CMNR was transferred to the FNB in 1983. The CMNR's current tasks are• to identify nutritional factors that may critically influence the physical and mental performance of military personnel under all environmental extremes,• to identify deficiencies in the existing database, • to recommend research that would remedy these deficiencies as well as approaches for studying the relationship of diet to physical and mental performance, and• to review and advise on standards for military feeding systems.Within this context, the CMNR was asked to focus on nutrient requirements for performance during operational missions rather than requirements for military personnel in garrison (the latter were judged to be not significantly different from those of the civilian population).Although the membership of the committee has changed periodically, the disciplines represented consistently have included human nutrition, nutritional biochemistry, performance physiology, food science, and psychology. For issues that require broader expertise than exists within the committee, the CMNR has convened workshops or utilized consultants. The workshops provide additional state-of-the-art scientific information and informed opinion for the consideration of the committee. COMMITTEE TASKS AND PROCEDURESThe request for this review of nutrition and immune function and its application to military operations originated with Army scientists from USARIEM and USAMRMC. In December 1995, a committee subgroup of the CMNR participated in a series of conference calls with USARIEM, USAMRMC, and other CMNR members to identify the key areas that should be reviewed and to solicit suggestions for names...

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Inflammatory cytokines in BAL fluid and pulmonary hemodynamics in high-altitude pulmonary edema

Cited by 139 publications

References 29 publications

Acute high-altitude sickness

Acute high-altitude sickness

Physical activity at moderate and high altitudes. Cardiovascular and respiratory morbidit

Military Strategies for Sustainment of Nutrition and Immune Function in the Field

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