Inflammatory cytokines kinetics define the severity and phase of nephropathia epidemica

Baigil’dina, A. A.; Khaiboullina, Svetlana F.; Martynova, Ekaterina; Анохин, В. А.; Lombardi, Vincent; Rizvanov, Albert A.

doi:10.2217/bmm.14.88

Cited by 19 publications

(25 citation statements)

References 44 publications

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“…High level in viral load of ANDV‐South samples could be related to the person‐to‐person transmission. Highly variable viral load values were observed among cases, suggesting that host–virus interaction could be a factor in HPS pathogenesis as was proposed previously [Dalrymple and Mackow, ; Guichard et al, ; Hepojoki et al, ; Baigildina et al, ].…”

Section: Discussionsupporting

confidence: 64%

Viral load of patients with hantavirus pulmonary syndrome in Argentina

Bellomo

Pires-Marczeski

Padula

2015

Journal of Medical Virology

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Hantavirus causes severe illness including pneumonia, which leads to hospitalization and often death. At present, there is no specific treatment available. The hantavirus pathogenesis is not well understood, but most likely both virus-mediated and host-mediated mechanisms, are involved. The aim of this study was to correlate viral load in samples of hantavirus pulmonary syndrome cases and hantavirus infected individuals, with clinical epidemiological parameters and disease outcome. The variables that could potentially be related with viral load were analyzed. The retrospective study included 73 cases or household contacts, with different clinical evolution. Viral load was measured by reverse-transcription and real time polymerase chain reaction. There was no statistically significant association between blood viral RNA levels and severity of disease. However, viral load was inversely correlated with IgG response in a statistically significant manner. The level of viral RNA was significantly higher in patients infected with Andes virus South lineage, and was markedly low in persons infected with Laguna Negra virus. These results suggest that the infecting viral genotype is associated with disease severity, and that high viral load is associated with a low specific IgG response. Sex, age and disease severity were not related with viral load. Further investigations increasing strikingly the number of cases and also limiting the variables to be studied are necessary.

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Section: Discussionsupporting

confidence: 64%

Viral load of patients with hantavirus pulmonary syndrome in Argentina

Bellomo

Pires-Marczeski

Padula

2015

Journal of Medical Virology

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“…In 1996, elevated plasma levels of IL‐6, IL‐10 and TNF were reported in PUUV‐infected HFRS patients . Since then, several reports have confirmed findings of strong cytokine responses in PUUV‐infected patients, including elevated plasma levels of IL‐2, IL‐6, IL‐8, IL‐10, TNF, TGF‐β1, IFN‐γ, VEGF and other inflammatory markers such as CRP . Elevated IL‐6 levels in plasma have been associated with more severe HFRS .…”

Section: Inflammatory Responses In Puuv and Other Hantavirus Infectionsmentioning

confidence: 90%

“…Not unlikely, the virus‐induced immune responses may contribute to the pathology of the diseases . It has been known for long that human hantavirus infection induces a strong inflammatory response with increased levels of pro‐inflammatory cytokines . How these responses might affect the disease outcome has, however, not been studied in detail.…”

Section: Inflammatory Responses In Puuv and Other Hantavirus Infectionsmentioning

confidence: 99%

Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe hantavirus‐associated syndromes

et al. 2019

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Klingstr€ om J, Smed-S€ orensen A, Maleki KT, Sol a-Riera C, Ahlm C, Bj€ orkstr€ om NK, Ljunggren HG (Karolinska University Hospital, Stockholm, Sweden; Ume a University, Ume a, Sweden). Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe hantavirus-associated syndromes (Key Symposium). J Intern Med 2019; 285: 510-523. latter conditions may also be applicable in severe hantavirus infections. Immune responses to Puumala virus infection / J. Klingstr € om et al.

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“…Different cytokines were discussed to be responsible for hantavirus pathogenesis [9, 38–41]. Several studies analyzed the role of VEGF in hantavirus disease [30, 42–45].…”

Section: Discussionmentioning

confidence: 99%

Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi

et al. 2016

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BackgroundHantavirus disease belongs to the emerging infections. The clinical picture and severity of infections differ between hantavirus species and may even vary between hantavirus genotypes. The mechanisms that lead to the broad variance of severity in infected patients are not completely understood. Host- and virus-specific factors are considered.Case presentationWe analyzed severe cases of hantavirus disease in two young women. The first case was caused by Puumala virus (PUUV) infection in Germany; the second case describes the infection with Dobrava-Belgrade virus (DOBV) in Russia. Symptoms, laboratory parameters and cytokine levels were analyzed and compared between the two patients. Serological and sequence analysis revealed that PUUV was the infecting agent for the German patient and the infection of the Russian patient was caused by Dobrava-Belgrade virus genotype Sochi (DOBV-Sochi). The symptoms in the initial phase of the diseases did not differ noticeably between both patients. However, deterioration of laboratory parameter values was prolonged and stronger in DOBV-Sochi than in PUUV infection. Circulating endothelial progenitor cells (cEPCs), known to be responsible for endothelial repair, were mobilized in both infections. Striking differences were observed in the temporal course and level of cytokine upregulation. Levels of angiopoietin-2 (Ang-2), vascular endothelial growth factor (VEGF), and stromal derived factor-1 (SDF-1α) were increased in both infections; but, sustained and more pronounced elevation was observed in DOBV-Sochi infection.ConclusionsSevere hantavirus disease caused by different hantavirus species did not differ in the general symptoms and clinical characteristics. However, we observed a prolonged clinical course and a late and enhanced mobilization of cytokines in DOBV-Sochi infection. The differences in cytokine deregulation may contribute to the observed variation in the clinical course.

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Inflammatory cytokines kinetics define the severity and phase of nephropathia epidemica

Abstract: Inflammatory cytokine kinetics associate with the severity and phase of NE. Our data support a role for inflammatory cytokines in the pathophysiology of NE.

Cited by 19 publications

References 44 publications

Viral load of patients with hantavirus pulmonary syndrome in Argentina

Viral load of patients with hantavirus pulmonary syndrome in Argentina

Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe hantavirus‐associated syndromes

Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi

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