Inflammatory Disease

Mycosis fungoides mimicking inflammatory linear verrucous epidermal nevus

“…In addition, lesional skin biopsies revealed very similar histological findings to those of ILVEN, such as a psoriasiform‐lichenoid pattern in which the lymphocytes predominate, sharply demarcated alteration of orthokeratosis and parakeratosis in the cornified layer and a thickened epidermis 15 . The lesions, however, had additional histological features consistent with MF (Pautrier's microabscesses, epidermotrophic mononuclear cell, accompanied scant spongiosis, numerous cerebriform lymphocytes, lymphocytes aligned as solitary units along the basal layer, epidermal lymphocytes larger than dermal lymphocytes, coarse bundles of collagen in the papillary dermis, and epitheliotropism in the hair follicle) 16 …”

“…The diagnosis of clinical variants of MF is often difficult to establish both clinically and histologically 16 . Although immunohistochemical and molecular biological studies have become helpful for establishing this diagnosis, interpretation of routine histological sections remains the most important tool 9 .…”

“…Although there has been increasing recognition that MF may occur in young children and adolescents, reports of childhood and adolescent MF are relatively rare 10 . Moreover, atypical lesions such as hypopigmented or pityriasis lichenoides‐like MF appear to arise more commonly in young persons 16 . Therefore, MF should be considered in the differential diagnosis of chronic dermatoses in young persons.…”