Inflammatory effects of snake venom myotoxic phospholipases A2

Teixeira, Catarina; Landucci, Elen C.T.; Antunes, Edson; Chacur, Marucia; Cury, Yara

doi:10.1016/j.toxicon.2003.11.006

Cited by 236 publications

(155 citation statements)

References 179 publications

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“…Snake venom phospholipases A2 (PLA2) show myotoxic activity and also evoke inflammatory and nociceptive responses (12). Subcutaneous injection of PLA2s isolated from Bothrops asper venom was shown to induce hyperalgesia in rats and administration around healthy sciatic nerve was found to produce mechanical allodynia ipsilateral to the injection (13).…”

Section: Discussionmentioning

confidence: 99%

Ailesel Kamptodaktili ve Periferik Nöropatili Üç Kız Kardeş

...

2012

Tftr

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Sum maryComplex regional pain syndrome (CRPS) is a painful and disabling disorder that can affect one or more extremities. The pathophysiology of CRPS is not clear but peripheral and central sensitization resulting in neurogenic inflammation has been held responsible. A 66-year-old male patient was admitted to our outpatient clinic with complaints of swelling, pain, warmth, and restriction in movements of the left upper extremity after a snake bite. Electromyographic evaluation was compatible with toxic neuropathy. A hand X-ray showed demineralization of the carpal bones. CRPS was diagnosed based on clinical and radiological findings. Medical and physical therapy were performed and symptomatic relief was obtained. This case is presented to emphasize snake bite as a rare cause of toxic neuropathy and CRPS. Turk J Phys Med Re hab 2012;58:69-71.

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Section: Discussionmentioning

confidence: 99%

Ailesel Kamptodaktili ve Periferik Nöropatili Üç Kız Kardeş

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2012

Tftr

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“…Inflammatory activity assays were performed as previously described (Barbosa et al, 2008;Teixeira et al, 2003). B. atrox venom (0.10 mg kg −1 ) diluted in 50 µL of a sterile saline solution was administered in the right gastrocnemius muscle of mice.…”

Section: Quantification Of Inflammatory Infiltrate In Musclementioning

confidence: 99%

INFLUENCE OF A LOW-LEVEL SEMICONDUCTOR GALLIUM ARSENATE LASER IN EXPERIMENTAL ENVENOMATION INDUCED BY <i>BOTHROPS ATROX</i> SNAKE VENOM

Sousa¹

2012

American Journal of Pharmacology and Toxicology

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Bothrops atrox is responsible for the majority of snakebite accidents in Brazilian Amazon and its venom can cause prominent local tissue damage. Experimental groups consisted of five male mice, each administered either ) was administered intramuscularly. The site of venom injection was irradiated by GaAs laser and some animals received antivenom intraperitoneally. GaAs laser irradiation administered in conjunction with antivenom, reduced pain, oedema, inflammation and myonecrosis induced by B. atrox venom in mice. The combined antivenom and GaAs laser treatment was more effective than separately treatments. The results suggest that laser therapy may reduce the local effects induced by B. atrox venom when associated with antivenom.

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“…Snake venoms are composed of a mixture of proteins and peptides (90-95%), but also include free amino acids, nucleotides, lipids, carbohydrates and metalloproteinase enzymes (5%) (14)(15)(16)(17)(18)(19). Although snakebites may be deadly, snake venoms comprise a biological resource that contains components of significant therapeutic value.…”

Section: Introductionmentioning

confidence: 99%

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et al. 2011

J. Venom. Anim. Toxins incl. Trop. Dis.

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Viruses depend on cell metabolism for their own propagation. The need to foster an intimate relationship with the host has resulted in the development of various strategies designed to help virus escape from the defense mechanisms present in the host. Over millions of years, the unremitting battle between pathogens and their hosts has led to changes in evolution of the immune system. Snake venoms are biological resources that have antiviral activity, hence substances of significant pharmacological value. The biodiversity in Brazil with respect to snakes is one of the richest on the planet; nevertheless, studies on the antiviral activity of venom from Brazilian snakes are scarce. The antiviral properties of snake venom appear as new promising therapeutic alternative against the defense mechanisms developed by viruses. In the current study, scientific papers published in recent years on the antiviral activity of venom from various species of snakes were reviewed. The objective of this review is to discuss the mechanisms of resistance developed by viruses and the components of snake venoms that present antiviral activity, particularly, enzymes, amino acids, peptides and proteins.Key words: snake venom, viruses, antiviral agents. Review ARticle The Journal of Venomous Animals and Toxins including Tropical Diseases ISSN 1678-9199 | 2011 | volume 17 | issue 4 | pages 387-393 INTRODUCTIONViruses are obligate intracellular parasites that depend on cell metabolism for their own propagation. This intimate virus-cell relationship led viruses to develop numerous survival strategies aimed at protecting themselves from the host defense system (1-4).One of the criteria for a successful viral infection is the ability to remain inside the host cell for the time required to allow replication of the viral genomic nucleic acid, envelopment and the production of new infectious virus progeny. The first barrier to be overcome is the host innate immune response (5).The association between virus persistence and disease in the host may lead to a long term relationship that does not result in any chronic virus-induced symptoms or in a fatal disease (6). Persistent viral infections constitute an example of immune evasion and, consequently, a successful relationship (7). Antiviral therapy has changed the natural history of numerous viral infections, delaying progression of the disease, improving the quality of life of infected individuals and reducing the frequency of hospitalization (8-10). Nevertheless, one of the principal problems today is therapeutic failure, including antiviral drug resistance (11, 12).The rich biodiversity in Brazil is an important source of wealth, since the country is home to at least 14% of the world's species, giving it an enormous advantage over other countries with poorer biodiversity, principally in a century in which biotechnology is expected to play such an important role in the global economy (13). Snake venoms are composed of a mixture of proteins and peptides (90-95%), but also include free amin...

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Inflammatory effects of snake venom myotoxic phospholipases A2

Cited by 236 publications

References 179 publications

Ailesel Kamptodaktili ve Periferik Nöropatili Üç Kız Kardeş

Ailesel Kamptodaktili ve Periferik Nöropatili Üç Kız Kardeş

INFLUENCE OF A LOW-LEVEL SEMICONDUCTOR GALLIUM ARSENATE LASER IN EXPERIMENTAL ENVENOMATION INDUCED BY <i>BOTHROPS ATROX</i> SNAKE VENOM

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