Inflammatory Endotype-Associated Airway Resistome in Chronic Obstructive Pulmonary Disease

Yi, Xinzhu; Li, Yanjun; Liu, Haiyue; Liu, Xiaomin; Yang, Junhao; Gao, Jingyuan; Yang, Yuqiong; Liang, Zhenyu; Wang, Fengyan; Chen, Dandan; Wang, Lingwei; Shi, Weijuan; Lam, David Chi‐Leung; Stämpfli, Martin R.; Jones, Paul; Chen, Rongchang; Wang, Zhang

doi:10.1128/spectrum.02593-21

Cited by 16 publications

(13 citation statements)

References 18 publications

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“…With the growth of age, the incidence of many lung diseases is also gradually increasing, among which chronic obstructive pulmonary disease and pulmonary fibrosis are the most significant [ 47 ]. At present, some progress has been made in the relationship between aging, and chronic obstructive pulmonary disease and pulmonary fibrosis [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

[Retracted] The Efficacy and Safety of Budesonide/Glycopyrronium/Formoterol in the Treatment of COPD in the Elderly

Guo

Chen

2022

Contrast Media & Molecular Imaging

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Objective. Chronic obstructive pulmonary disease (COPD) is a major and difficult disease of the chronic respiratory system that is common and frequent, with a huge disease burden. The aim of this study was to investigate the efficacy and safety of budesonide/glyburide/formoterol fumarate (BGF) in the treatment of COPD. Methods. A comprehensive literature search was conducted in PubMed, Embase, Cochrane Library, and Web of Science. The basic features of the seven pieces of literature were identified using the search strategy. The sample size range was 130∼1264. Results. The effects of BGF increased FEV1 in patients with COPD (mean difference = 2.86, 95%CI: 2.71–3.01, p < 0.00001 ). The effects of BGF improved in patients with ≥1 TEAE in patients with COPD, and was not statistically significant after treatment (Odds rate = 1.00, 95%CI: 0.85–1.17, p = 0.97 ). The effects of BGF increased in patients with TEAEs related a to study treatment in patients with COPD (odds rate = 1.27, 95% CI: 1.03–1.57, p = 0.02 ). The effects of BGF in decreased patients with serious TEAEs in patients with COPD (odds rate = −0.02, 95% CI: −0.03–−0.00, p = 0.04 ). The effects of BGF decreased the death rate in patients with COPD, and were not statistically significant after treatment (odds rate = 0.77, 95% CI: 0.31–1.97, p = 0.59 ). The effects of BGF decreased the hypertension rate in patients with COPD (odds rate = 0.92, 95% CI: 0.44–1.89, p = 0.81 ), and was not statistically significant after treatment. The effects of BGF increased pneumonia in patients with COPD (odds rate = 1.55, 95% CI: 0.81–2.97, p = 0.19 ), and were not statistically significant after treatment. The effects of BGF increased FEV1, increased patients with TEAEs related a to study treatment, and decreased patients with serious TEAEs in patients with COPD. Conclusion. This study elucidates the efficacy and safety of BGF in the treatment of COPD with a view to providing a clinical reference.

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Section: Discussionmentioning

confidence: 99%

[Retracted] The Efficacy and Safety of Budesonide/Glycopyrronium/Formoterol in the Treatment of COPD in the Elderly

Guo

Chen

2022

Contrast Media & Molecular Imaging

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“…Therefore, the use of antibiotics is particularly prevalent in COPD, especially in primary health care who receive three times more antibiotic prescriptions than general population [43]. The accompanying rapid growth of antibiotic resistance is a health challenge [27]. The maintenance treatment with macrolide antibiotics has been proved to be effective in reducing exacerbations in COPD [44], but long-term macrolide therapy contributes to antibiotic resistance [45].…”

Section: Discussionmentioning

confidence: 99%

“…Alterations of antibiotic resistance genes before and after PR Antibiotics are commonly prescribed for the treatment of acute exacerbations of COPD, accompanied by the increased risk of antibiotic resistance in the COPD patients [27]. In view of this situation, we analyzed the resistance genes of respiratory microbiome before and after 2-week PR.…”

Section: Alterations Of Respiratory Microbiome Function Before and Af...mentioning

confidence: 99%

Pulmonary rehabilitation can alter the respiratory microbiome in patients with COPD

Zhang

et al. 2023

Preprint

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Background As one of the main causes ofchronic obstructive pulmonary disease (COPD), respiratory microbiome is of great significance to the disease progression. Meanwhile, pulmonary rehabilitation (PR), as an effective nonpharmacologicintervention for COPD, evaluation of the efficacy is limited to the improvement of symptoms and lung function, which is one-sided to a certain extent. Therefore, an individualized 2-week intensive PR programme was established in the present study for patients with COPD to investigate whether this short course of PR can have impact on respiratory microbiome in patients. Methods The patients with stable COPD who participated in this study underwent short-term, high-intensity and center-based PR programme, which included two major components: respiratory muscle training and vibration expectoration. Sputum samples were collected before and after the PR to detect alterations of respiratory microbiome by metagenomic sequencing. The main purpose was to observe changes of composition, function and resistance genes in respiratory microbiomebefore and after PR, and explore the relationship of respiratory microbiome with lung function and symptoms. Results After the 2-week intensive PR, the abundance of Firmicutes, Actinobacteria and Bacteroidetesdecreased, while that of Proteobacteria increased at the phylum level; the abundance of Streptococcus and Prevotella decreased, while that of Neisseria increased at the genus level. Concomitantly, it was found that Firmicutes, Actinobacteria, Streptococcus and Prevotella were negatively correlated with lung function and positively correlated with CAT score, while Neisseria was positively correlated with lung function and negatively correlated with CAT score. Based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, the functional abundance of most respiratory microbiome decreased after 2-week PR. Simultaneously, the species function abundance was negatively correlated with the lung function of COPD. In addition, the resistance gene fluctuated with the attribution of the species, and the macrolide resistance genes of COPD were significantly reduced after 2-week PR. Conclusions The short course of intensive PR can alter the composition, function and antibiotic resistance genes of respiratory microbiome in patients with COPD, which plays a role by promoting the self-regulation ability of patients. This study provides a novel, gentle and non-pharmacologic intervention for the regulation of microbiome in the future.

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“…Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease related to inflammation and the source of heterogeneity is related to the inflammatory endotypes involved in neutrophils and eosinophils [27].More and more studies have shown that N6 adenosine methylation (m6A) is the most common RNA regulator, which can modify the epigenetics of proteins [28].However, the mechanism of m6A methylation regulator in COPD is not clear. Therefore, this study explored the relationship between the gene expression matrix of COPD in GEO database and m6A typing and immune cell infiltration by using R software.…”

Section: Discussmentioning

confidence: 99%

Exploring the significance of RNA N6 methyladenosine regulatory factor in the diagnosis and subtype classification of chronic obstructive pulmonary disease based on GEO database

Zhang¹,

Gao²,

Li³

et al. 2022

Preprint

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N6 methyladenosine (m6A) is a very rich mRNA modifier, which plays animportant role in biological processes such as lipid metabolism, autophagy,macrophage activity and inflammatory response.However, the role of m6A regulatorin COPD remains unknown.In this study, the expression values of 23 m6Amethylation regulators were obtained by analyzing the gene expression matrix ofCOPD patients and normal controls in GSE76925 data set.Eleven candidate m6Aregulators were selected by random forest model to construct nomination graphmodel and predict the risk of COPD.The decision curve found that patients couldbenefit from the nomination model constructed.By consensus cluster analysis, m6Aregulators in COPD patients were divided into two subtypes (clusterA andclusterB) .The m6A pattern was quantified by principal component analysis algorithm.It was found that the m6A score of patients in clusterA was higher than that ofclusterB.Differential genes (DEGs) were screened by m6A typing and the differentialgenes were analyzed by Kyoto genome and genome Encyclopedia (KEGG). It wasfound that the differential genes were mainly enriched in NF-kB and TNF signalpathway.In addition, through gene and immune cell correlation analysis, it was foundthat the patients in m6A clusterB were related to the immunity dominated byneutrophil and eosinophil traps,however the patients in clusterA are related to theimmunity dominated by monocyte traps.Therefore, the discovery of m6A patternthrough m6A typing related genes and immune cells may be a new strategy to guidethe treatment of COPD.

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Inflammatory Endotype-Associated Airway Resistome in Chronic Obstructive Pulmonary Disease

Cited by 16 publications

References 18 publications

[Retracted] The Efficacy and Safety of Budesonide/Glycopyrronium/Formoterol in the Treatment of COPD in the Elderly

[Retracted] The Efficacy and Safety of Budesonide/Glycopyrronium/Formoterol in the Treatment of COPD in the Elderly

Pulmonary rehabilitation can alter the respiratory microbiome in patients with COPD

Exploring the significance of RNA N6 methyladenosine regulatory factor in the diagnosis and subtype classification of chronic obstructive pulmonary disease based on GEO database

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