Inflammatory events in endometrial adenocarcinoma

Wallace, Alison E.; Gibson, Douglas A; Saunders, Philippa T. K.; Jabbour, Henry N.

doi:10.1677/joe-10-0072

Cited by 113 publications

(106 citation statements)

References 191 publications

(114 reference statements)

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“…In addition to a wealth of cell and animal experimental studies, LC ω-3 PUFAs have been shown to hold antiinflammatory properties in epidemiologic studies (11,12) and randomized clinical trials (13)(14)(15). They are further hypothesized to have chemoprotective properties for endometrial cancer (and other estrogendependent cancers), as inhibition of inflammation via NF-κB and COX-2 is associated with reduced estrogen synthesis (24)(25)(26), which is thought to be a critical component for endometrial proliferation (27,28). However, this latter hypothesized mechanism predominantly represents inhibition of estrogen signaling via aromatase, which would be expected to occur primarily among noncycling (i.e., postmenopausal) women.…”

Section: Discussionmentioning

confidence: 99%

Associations of Dietary Long-Chain ω-3 Polyunsaturated Fatty Acids and Fish Consumption With Endometrial Cancer Risk in the Black Women's Health Study

Brasky¹,

Sponholtz²,

Palmer³

et al. 2016

Am. J. Epidemiol.

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Dietary long-chain (LC) ω-3 polyunsaturated fatty acids (PUFAs), which derive primarily from intakes of fatty fish, are thought to inhibit inflammation and de novo estrogen synthesis. This study prospectively examined the associations of dietary LC ω-3 PUFAs and fish with endometrial cancer risk in 47,602 African-American women living in the United States, aged 21-69 years at baseline in 1995, and followed them until 2013 (n = 282 cases). Multivariable-adjusted Cox regression models estimated hazard ratios and 95% confidence intervals for associations of LC ω-3 PUFA (quintiled) and fish (quartiled) intake with endometrial cancer risk, overall and by body mass index (BMI; weight (kg)/height (m) 2 ). The hazard ratio for quintile 5 of total dietary LC ω-3 PUFAs versus quintile 1 was 0.79 (95% confidence interval (CI): 0.51, 1.24); there was no linear trend. Hazard ratios for the association were smaller among normal-weight women (BMI <25: hazard ratio (HR) = 0.53, 95% CI: 0.18, 1.58) than among overweight/ obese women (BMI ≥25: HR = 0.88, 95% CI: 0.54, 1.43), but these differences were not statistically significant. Fish intake was also not associated with risk (quartile 4 vs. quartile 1: HR = 0.86, 95% CI: 0.56, 1.31). Again hazard ratios were smaller among normal-weight women (HR = 0.65) than among overweight/obese women (HR = 0.94). While compatible with no association, the hazard ratios observed among leaner African-American women are similar to those from recent prospective studies conducted in predominantly white populations.African-American women; docosahexaenoic acid; eicosapentaenoic acid; endometrial cancer; fish; uterine cancer; women's reproductive health Abbreviations: BMI, body mass index; BWHS, Black Women's Health Study; CI, confidence interval; DHA, docosahexaenoic acid; DPA, docosapentaenoic acid; EPA, eicosapentaenoic acid; FFQ, food frequency questionnaire; HR, hazard ratio; LC, long-chain; PUFA, polyunsaturated fatty acid; VITAL, Vitamins and Lifestyle; WHI, Women's Health Initiative.Endometrial cancer is the fourth most common cancer and the leading gynecological malignancy diagnosed in US women (1). Incidence rates are about 9% lower for African-American women relative to white women (2), but a recent study of Surveillance, Epidemiology, and End Results data that corrected for hysterectomy prevalence indicated a higher incidence in black women (3).

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Section: Discussionmentioning

confidence: 99%

Associations of Dietary Long-Chain ω-3 Polyunsaturated Fatty Acids and Fish Consumption With Endometrial Cancer Risk in the Black Women's Health Study

Brasky¹,

Sponholtz²,

Palmer³

et al. 2016

Am. J. Epidemiol.

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“…ИЛ-6, ИЛ-8 и ФНО-α, являясь провоспалительными цитокинами, под-держивают в организме воспалительную направленность иммунных реакций. Повышение их уровня отмечается при атеросклерозе, остеопорозе, депрессии, онкологиче-ских заболеваниях репродуктивных органов, уровень их повышения напрямую коррелирует с прогнозом течения онкологического заболевания, данные цитокины секре-тируются раковыми клетками для поддержания патологи-ческой пролиферации [15,16]. Именно поэтому при изна-чально повышенном уровне ИЛ-6 и ИЛ-8 снижение их на фоне лечения мы считаем прогностически благоприят-ным моментом.…”

Section: Discussionunclassified

The serum levels of some immunoregulatory proteins and cytokines during menopausal hormonal and nonhormonal therapies

Исакова¹,

Bazhenova²,

Зорина³

et al. 2015

Ross. vestn. akush.-ginekol.

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“…The transforming tissues exude prostaglandins and cyclooxygenases. Irreversible malignant proliferation of the endometrium takes place (413,414).…”

Section: Ebvmentioning

confidence: 99%

Molecular biology of oncogenic inflammatory processes. I. Non-oncogenic and oncogenic pathogens, intrinsic inflammatory reactions without pathogens, and microRNA/DNA interactions (Review)

Sinkovics

2011

Int J Oncol

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Abstract. In some inflammasomes tumor cells are generated. The internal environment of the inflammasome is conducive to the induction of malignant transformation. Epigenetic changes initiate this process. The subverted stromal connective tissue cells act to promote and sustain the process of malignant trans formation. In its early stages, the premalignant cells depend on paracrine circuitries for the reception of growth factors. The ligands are derived from the connective tissue, and the receptors are expressed on the recipient premalignant cells. The initial events are not a direct attack on the protooncogenes, and thus it may be entirely reversible. Epigenetic processes of hypermethylation of the genes at the promoters of tumor suppressor genes (to silence them), and deacetylation of the histones aimed at the promoters of protooncogenes (to activate them) are ongoing. A large number of short RNA sequences (interfering, micro, short hairpin, noncoding RNAs) silence tumor suppressor genes, by neutralizing their mRNAs. In a serial sequence oncogenes undergo amplifications, pointmutations, translocations and fusions. In its earliest stage, the process is reversible by demethylation of the silenced suppressor gene promoters (to reactivate them), or reacetylation of the histones of the oncogene promoters, thus deactivating them. The external administration of histone deacetylase inhibitors usually leads to the restoration of histone acetylation. In time, the uncorrected processes solidify into constitutive and irreversible gene mutations. Some of the pathogens inducing inflammations with consquential malignant transformation contain oncogenic gene sequences (papilloma viruses, EpsteinBarr virus, Kaposi's sarcomaassociated herpesvirus, hepatitis B and C viruses, Merkel cell polyoma virus, Helicobacter pylori, enterotoxigenic Bacteroides fragilis). These induced malignancies may be multifocal. Other pathogens are devoid of any known oncogenic genomic sequences (mycoplasma vavcarcinogenesis, chlamydia MALTlymphoma genesis). In these cases the host's inflammatory reactions induce the malignant transformation in serial sequences of gene alterations initiated by hypoxia and reactive oxygen and nitrogen species generation. Carcinogenic intrinsic inflammatory processes endogenously initiated without a pathogen are recognized. Chronic inflammatory processes signal the RNA/DNA complex. In response, the DNA may revert into its ancient primordial 'immortal' format, which the clinics recognize as 'oncogenesis'. The DNA remains the ultimate master of bioengineering in order to sustain life. A discussion on the most versatile and resistant primordial RNA/ DNA complex and the pre, proto, and unicellular world in which they coexisted is included. Contents1. Pathogens without oncogenic genomic sequences activating cellular oncogenes 2. The inflammasome 3. Tumor cell colonies generated in the inflammasomes 4. Pathogens with potentially oncogenic genomic sequences 5. Mechanisms of inflammatory carcinogenesis Pathogens without oncogenic...

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Inflammatory events in endometrial adenocarcinoma

Cited by 113 publications

References 191 publications

Associations of Dietary Long-Chain ω-3 Polyunsaturated Fatty Acids and Fish Consumption With Endometrial Cancer Risk in the Black Women's Health Study

Associations of Dietary Long-Chain ω-3 Polyunsaturated Fatty Acids and Fish Consumption With Endometrial Cancer Risk in the Black Women's Health Study

The serum levels of some immunoregulatory proteins and cytokines during menopausal hormonal and nonhormonal therapies

Molecular biology of oncogenic inflammatory processes. I. Non-oncogenic and oncogenic pathogens, intrinsic inflammatory reactions without pathogens, and microRNA/DNA interactions (Review)

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