Inflammatory factors, <scp>genetic variants</scp>, and predisposition for preterm birth

Couceiro, Joana; Matos, Irina; Mendes, José João; Baptista, Pedro V.; Fernandes, Alexandra R.; Quintas, Alexandre

doi:10.1111/cge.14001

Cited by 26 publications

(27 citation statements)

References 142 publications

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“…Thus, the DECs derived from the above genes might mediate the essential processes of ECM remodeling and collagen degradation in PTB. Since it is generally accepted that pro-inflammatory responses and immune tolerance breaking are the important causes of fetal membrane damage and rupture, uterine contractions, and cervical changes, thus resulting in the occurrence of PTB, we speculated that the DECs in the chorion might regulate inflammatory processes in the development of PTB (83)(84)(85)(86). The evidence was provided by the target miRNAs and coexpressed mRNAs.…”

Section: Discussionmentioning

confidence: 99%

The landscape of circular RNA in preterm birth

et al. 2022

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BackgroundPreterm birth (PTB) is a multifactorial syndrome that seriously threatens the health of pregnant women and babies worldwide. Recently, circular RNAs (circRNAs) have been understood as important regulators of various physiological and pathological processes. However, the expression pattern and potential roles of circRNAs in PTB are largely unclear.MethodsIn this study, we extracted and analyzed the circRNA expression profiles in maternal and fetal samples of preterm and term pregnancies, including maternal plasma, maternal monocytes, myometrium, chorion, placenta, and cord blood. We identified the circRNAs which is associated with PTB in different tissues and explored their relationships from the perspective of the overall maternal-fetal system. Furthermore, co-expression analysis of circRNAs and mRNAs, target microRNAs (miRNAs), and RNA-binding proteins (RBPs), provided new clues about possible mechanisms of circRNA function in PTB. In the end, we investigated the potential special biofunctions of circRNAs in different tissues and their common features and communication in PTB.ResultsSignificant differences in circRNA types and expression levels between preterm and term groups have been proved, as well as between tissues. Nevertheless, there were still some PTB-related differentially expressed circRNAs (DECs) shared by these tissues. The functional enrichment analysis showed that the DECs putatively have important tissue-specific biofunctions through their target miRNA and co-expressed mRNAs, which contribute to the signature pathologic changes of each tissue within the maternal-fetal system in PTB (e.g., the contraction of the myometrium). Moreover, DECs in different tissues might have some common biological activities, which are mainly the activation of immune-inflammatory processes (e.g., interleukin1/6/8/17, chemokine, TLRs, and complement).ConclusionsIn summary, our data provide a preliminary blueprint for the expression and possible roles of circRNAs in PTB, which lays the foundation for future research on the mechanisms of circRNAs in PTB.

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Section: Discussionmentioning

confidence: 99%

The landscape of circular RNA in preterm birth

et al. 2022

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“…It had MAF of 0.164 in the CEU population (1000Genomes). The associations between TNF-308 haplotypes and the susceptibility to gestational diabetes mellitus, coronary artery disease, rheumatoid arthritis have been described [24][25][26][27][28][29]. The association of the rs1800629 variant with affected gene expression was initially discovered in previous studies [30].…”

Section: Selection Of Snps Genotyped In This Studymentioning

confidence: 99%

Association Of Inflammation Gene Polymorphism With Increased Risk Of Metabolic Syndrome In Tatar Ethnic Group

2022

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Background and objective — Chronic low-grade inflammation plays an important role in pathophysiology of metabolic syndrome (MetS). The aim of our study was to determine the associations of polymorphic variants of inflammation genes with MetS and serum levels of high-sensitivity C-reactive protein (hsCRP) and tumor necrosis factor-α (TNF-α) in Tatar patients (Bashkortostan). Methods — In our case-control cross-sectional study, 271 MetS patients and 327 healthy Tatars were genotyped for the SNPs in CRP, TNFA, LTA, TNFRSF1B genes. Results — TNFRSF1B (rs1061624) was associated with the MetS [odds ratio (OR)=0.49, рADJ=0.0034] and TNF-α level (p=0.033). TNFA (rs1800629) was associated with TNF-α (p=0.015), albuminuria (p=0.013). CRP (rs2794521) was associated with fasting (p=0.0096) and postprandial (p=0.01) insulin, HOMA-IR (homeostasis model assessment of insulin resistance, p=0.0019), hsCRP (p=0.036), waist-hip ratio (WHR, p=0.007), body mass index (BMI, p=0.039). The participants having the C-C haplotype of CRP rs2794521-rs1130864 were more common among MetS patients (OR=1.99, p=0.032). T-T haplotype in CRP was associated with hsCRP (p=0.0043), low-density lipoprotein cholesterol (p=0.025), HOMA-IR (p=0.00029), glycated hemoglobin (p=0.006), postprandial (p=0.0006) and fasting insulin (p=0.00031), WHR (p=0.00012), BMI (p=0.00024). Conclusions — The data confirms that the variants of inflammation genes CRP, TNFA, TNFRSF1B are associated with levels of TNF-α, hsCRP. Novel association of TNFRSF1B (rs1061624) with MetS had been identified.

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“…PTB has become a global public health issue, with mounting evidence indicating a syndrome attributed to various pathological processes ( 5 ). Many studies have revealed that genetic variations in pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1α (IL-1α) are associated with an increased risk of PTB ( 6 ). However, the relationship between genetic polymorphisms in anti-inflammatory cytokines and PTB risk remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Association of IL-4 and IL-10 Polymorphisms With Preterm Birth Susceptibility: A Systematic Review and Meta-Analysis

Zhou²,

Xu³

et al. 2022

Front. Immunol.

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ObjectivePreterm birth (PTB) is a typical inflammatory disease with unclear pathogenesis. The studies investigating the relationship between anti-inflammatory factors IL-4 and IL-10 gene polymorphisms and PTB produced conflicting results. This systematic review and meta-analysis aimed to summarize the effects of IL-4 and IL-10 gene polymorphisms and clarify their possible association with PTB.MethodsA systematic literature review was conducted using PubMed, Web of Science, and Cochrane library (up to 02 April 2022). The MeSH terms, related entry terms, and other names in “Gene” database were used to find relevant articles. A fixed- or random-effects model was used to calculate the significance of IL-4 and IL-10 gene polymorphisms, depending on study heterogeneity. The odds ratios (OR) and 95% confidence intervals (CIs) were calculated in the allele, recessive, dominant, co-dominant, and over-dominant models. The Eggers publication bias plot was used to graphically represent the publication bias.ResultsPolymorphisms in two interleukins (IL-4-590C/T (rs2243250) = 5 and IL-10-592A/C (rs1800872), -819T/C (rs1800871) and -1082A/G (rs1800896) = 16) were found in 21 articles. Overall, only the over-dominant gene model AA + GG vs. AG revealed significant association between IL-10-1082A/G (rs1800896) and PTB (OR [95% CI] = 0.87 [0.76, 0.99], p = 0.04). However, in the allele model, recessive model, dominant model, co-dominant model, and over-dominant model, the polymorphisms for IL-4-590C/T (rs2243250), IL-10-592A/C (rs1800872), and IL-10-819T/C (rs1800871) were not found to be associated with the risk of PTB. In gene models, no statistically significant association was found between IL-4-590C/T (rs2243250), IL-10-592A/C (rs1800872), IL-10-819T/C (rs1800871), and IL-10-1082A/G (rs1800896) polymorphisms and PTB in subgroup analyses by racial or control group Hardy-Weinberg Equilibrium (HWE) p-value. Eggers’s publication bias plot and heterogeneity test (I2<50%, p = 0.05) of IL-10-1082A/G (rs1800896) suggested that the funnel asymmetry could be due to publication bias rather than heterogeneity.ConclusionThe current study suggests that the over-dominant gene model AA + GG vs. AG of IL-10-1082A/G (rs1800896) polymorphism may be associated with genetic susceptibility to PTB and may have a protective function against PTB risk. There was unclear association found between IL-4-590C/T (rs2243250), IL-10-592A/C (rs1800872) and IL-10-819T/C (rs1800871) polymorphisms and PTB. Due to the limitations of included studies and the risk of publication bias, additional research is required to confirm our findings.Systematic Review Registrationhttps://inplasy.com/inplasy-2022-4-0044, identifier INPLASY202240044.

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Inflammatory factors, genetic variants, and predisposition for preterm birth

Cited by 26 publications

References 142 publications

The landscape of circular RNA in preterm birth

The landscape of circular RNA in preterm birth

Association Of Inflammation Gene Polymorphism With Increased Risk Of Metabolic Syndrome In Tatar Ethnic Group

Association of IL-4 and IL-10 Polymorphisms With Preterm Birth Susceptibility: A Systematic Review and Meta-Analysis

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