Inflammatory Fibrous Hyperplasia Associated with Chondroid Metaplasia - Report and Morphological Analysis of Five Cases

Abstract

Inflammatory fibrous hyperplasia (IFH) is a common reactive lesion in dental prostheses users that may be associated with chondroid metaplasia (CM). Metaplasia is an adaptive cellular process that may be caused by trauma. We reported here five cases of IFH associated with CM and analyzed morphologically the deposition of collagen in these lesions. Patients had a mean age of 58.8 years-old and were ill-fitting dental prostheses users. They presented nodular lesions located in the anterior maxilla. Microscopically, it was observed hyperplastic fibrous connective tissue with chronic inflammatory infiltrate and hyaline cartilage. No morphological differences were observed in collagen deposition under light microscopy, but quantitative analysis revealed a significantly higher collagen deposition at the connective tissue near CM (p = 0.015). IFH associated with CM affects ill-fitting dental prostheses users. The presence of CM is not significant to the lesion prognosis. However, its formation and the higher collagen deposition near it reinforces the IFH reactive origin.

A report of an unusual case of cartilaginous choristoma of the tongue and review

“…Nonetheless, the development of cartilaginous tissue in soft tissues may also suggest an inflammatory fibrous hyperplasia associated with chondroid metaplasia or a chondroma (a benign neoplasm). However, cartilaginous choristoma is characterized by the presence of lobules of mature hyaline cartilage, with chondrocytes usually growing in clusters 12,17 …”

“…However, cartilaginous choristoma is characterized by the presence of lobules of mature hyaline cartilage, with chondrocytes usually growing in clusters. 12,17 Cartilaginous choristomas are rare in the oral cavity and, clinically, are characterized by nodular, ovoid and firm growth. Therefore, they have non-specific clinical features that mimic both benign conditions, such as fibroma, pyogenic granuloma, pleomorphic adenoma, neurofibroma, solitary fibrous tumour, granular cell tumour, ectomesenchymal chondromyxoid tumour and malignant such as chondrosarcomas.…”