Inflammatory hyperplasia: From diagnosis to treatment

Shukla, Pradeep; Dahiya, Varun; Kataria, Prerna; Sabharwal, Shreya

doi:10.4103/0972-124x.128252

Cited by 13 publications

(13 citation statements)

References 4 publications

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“…One of them is reactive hyperplastic lesions (RHLs) which represent the most frequently encountered oral mucosal lesions in humans. RHLs represent a reaction to some kind of irritations or low-grade injuries (Shukla et al 2014). Periodontologists and oral and maxillofacial surgeons often use the term of 'epulis' to describe RHLs.…”

Section: Cancersmentioning

confidence: 99%

A mini review of histological and genetic oral lesions in adult and elderly patients referred to Shiraz Dentistry School

2015

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Oral diseases include all lesions which affect the oral cavity, periodontal areas and related structures and are associated with pain and discomfort, eating difficulties and problems with speech and communication. Therefore, familiarity with these diseases is necessary for dentists and clinicians. Over the past several decades, long-term outcomes associated with oral lesions and their management has been of increasing concern and dentists must be familiar with these pathological, histological and genetic lesions and how to manage them. This article is a mini review of some common oral lesions especially in adults and elderly patients who attended Shiraz Dentistry School, Iran, and is designed to help all dental practitioners to be more ready to deal with these lesions.

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Section: Cancersmentioning

confidence: 99%

A mini review of histological and genetic oral lesions in adult and elderly patients referred to Shiraz Dentistry School

2015

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“…Plaque accumulation and bacterial infection resulting from poor oral hygiene are significant predisposing factors [ 41 , 74 ]. Other examples are inflammatory pseudotumors [ 53 ] and inflammatory fibrous hyperplasia due to local irritants [ 75 ]. Enlargement associated with hereditary factors and co-existing with genetic diseases and syndromes [ 4 , 9 – 14 , 25 , 35 , 41 ] Drug-induced gingival enlargement [ 15 – 18 , 20 , 39 ] Gingival enlargement of unknown etiology [ 1 , 37 , 40 , 76 ] …”

Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Gingival fibromatosis: clinical, molecular and therapeutic issues

Gawron

Łazarz‐Bartyzel

Potempa

et al. 2016

Orphanet J Rare Dis

103

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Gingival fibromatosis is a rare and heterogeneous group of disorders that develop as slowly progressive, local or diffuse enlargements within marginal and attached gingiva or interdental papilla. In severe cases, the excess tissue may cover the crowns of the teeth, thus causing functional, esthetic, and periodontal problems, such as bone loss and bleeding, due to the presence of pseudopockets and plaque accumulation. It affects both genders equally. Hereditary, drug-induced, and idiopathic gingival overgrowth have been reported. Hereditary gingival fibromatosis can occur as an isolated condition or as part of a genetic syndrome. The pathologic manifestation of gingival fibromatosis comprises excessive accumulation of extracellular matrix proteins, of which collagen type I is the most prominent example. Mutation in the Son-of-Sevenless-1 gene has been suggested as one possible etiological cause of isolated (non-syndromic) hereditary gingival fibromatosis, but mutations in other genes are also likely to be involved, given the heterogeneity of this condition. The most attractive concept of mechanism for drug-induced gingival overgrowth is epithelial-to-mesenchymal transition, a process in which interactions between gingival cells and the extracellular matrix are weakened as epithelial cells transdifferentiate into fibrogenic fibroblast-like cells. The diagnosis is mainly made on the basis of the patient’s history and clinical features, and on histopathological evaluation of affected gingiva. Early diagnosis is important, mostly to exclude oral malignancy. Differential diagnosis comprises all pathologies in the mouth with excessive gingival overgrowth. Hereditary gingival fibromatosis may present as an autosomal-dominant or less commonly autosomal-recessive mode of inheritance. If a systemic disease or syndrome is suspected, the patient is directed to a geneticist for additional clinical examination and specialized diagnostic tests. Treatments vary according to the type of overgrowth and the extent of disease progression, thus, scaling of teeth is sufficient in mild cases, while in severe cases surgical intervention is required. Prognosis is precarious and the risk of recurrence exists.

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“…Estas lesiones tumorales no son neoplásicas, pero indican un proceso crónico en el que se produce una reparación exagerada. El trauma crónico puede inducir inflamación que produce tejido de granulación con células endoteliales y células inflamatorias crónicas y, más tarde, los fibroblastos proliferan y se manifiestan como un crecimiento excesivo llamado hiperplasia reactiva (Shukla et al, 2014). Debemos tener en cuenta que el verdadero tratamiento beneficioso de estas lesiones no es solo la eliminación de la lesión, sino esencialmente la eliminación de la causa de las lesiones (Palmeira, Florencio, Silva Filho, Silva y Araújo, 2013).…”

Section: Boza Oreamunno Y López Sotounclassified

“…La mucosa oral está constantemente bajo la influencia de varios estímulos internos y externos, por lo cual puede presentar irritación, inflamación, una gama de trastornos del desarrollo y afecciones neoplásicas (Shukla, Dahiya, Kataria y Sabharwal, 2014). Estas lesiones a menudo se presentan como lesiones generalizadas o localizadas (Effiom, Adeyemo y Soyele, 2011), se asocian con sitios anatómicos específicos y características del paciente como la edad, el sexo y la etnia (Al-Khateeb, 2009; Dovigi, Kwok, Eversole y Dovigi, 2016).…”

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Análisis retrospectivo de las lesiones de la mucosa oral entre 2008-2015 en el internado clínico de odontología de la Universidad de Costa Rica

Oreamuno¹,

Soto²

2019

PSM

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Objetivo: determinar la frecuencia de las diferentes lesiones de la mucosa oral en el internado clínico de la Facultad de Odontología de la Universidad de Costa Rica (UCR). Metodología: estudio retrospectivo de 263 informes de lesiones orales recuperados del archivo de biopsias de la Facultad de Odontología de la UCR del 2008 a 2015. Se evaluaron y analizaron de forma descriptiva y cualitativa información sobre el sexo, edad, localización de la lesión y diagnóstico histopatológico. Resultados: los casos de lesiones de la mucosa oral afectaron preferentemente a las mujeres (n= 144; 54.8 %), el promedio de edad fue 48.8 años (16.4 DS) y con lesiones predominantemente localizadas en lengua (n= 68; 25.9 %), encía (n=62; 23.6 %) y labio (n=61; 23.2 %). Las lesiones proliferativas no neoplásicas (n=101; 38.7 %), lesiones potencialmente malignas (n=29; 11.1 %) y lesiones epiteliales benignas y malignas (n=24; 9.1 %) fueron los grupos más prevalentes. Las cuatro lesiones más predominantes fueron la hiperplasia fibrosa, hiperplasia fibrosa inflamatoria, liquen plano e hiperqueratosis sin atipia. Conclusiones: las lesiones proliferativas no neoplásicas fueron las predominantes, siendo en forma individual la hiperplasia fibrosa la lesión más prevalente. Estos resultados pueden ser útiles para comprender la distribución de las enfermedades bucales en una muestra nacional.

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Inflammatory hyperplasia: From diagnosis to treatment

Cited by 13 publications

References 4 publications

A mini review of histological and genetic oral lesions in adult and elderly patients referred to Shiraz Dentistry School

A mini review of histological and genetic oral lesions in adult and elderly patients referred to Shiraz Dentistry School

Gingival fibromatosis: clinical, molecular and therapeutic issues

Análisis retrospectivo de las lesiones de la mucosa oral entre 2008-2015 en el internado clínico de odontología de la Universidad de Costa Rica

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