Inflammatory Indicators in Peripheral Blood in Sudden Sensorineural Hearing Loss Patients With Different Audiogram Shapes

Yao, Yuting; Guo, Qinghua; Luo, Wei; Yang, Ming; Liu, Jing; Hou, Jie; She, Wandong

doi:10.1177/01455613221132115

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…To our knowledge, this is the rst study to examine the relationship between the SII and HL. Yuting Yao et al previously reported that the blood immune marker SII in patients with both low-frequency and high-frequency hearing loss was signi cantly greater than that in normal controls 19 . In addition, Xu Zhang et al reported that patients with sudden sensorineural hearing loss (SSNHL) exhibit in ammatory and immune responses in vivo, and the SII plays an important role in predicting the prognosis and guiding treatment of these patients.…”

Section: Discussionmentioning

confidence: 96%

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Association of systemic inflammatory biomarkers with hearing loss: Results from NHANES 1999–2020 analyses

Wang,

He,

Huang

et al. 2024

Preprint

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Background:Hearing loss (HL) is a prevalent global health issue with a complex etiology in whichinflammation plays a significant role. The systemic immune inflammatory index (SII), a novel biomarker reflecting systemic inflammation, is hypothesized to correlate with HL. Methods: Utilizing National Health and Nutritional Health Survey (NHANES) data from 1999–2020, this study analyzed the relationship between the SII and HL, categorized ashigh-frequency hearing loss (HFHL) orspeech-frequency hearing loss (SFHL). Blood samples were collected to calculate the SII. Weighted multivariate linear and logistic regression analyses were used to examine the linear relationship between the SII and hearing loss. After the SII was categorized into quartiles, a trend test was applied to assess the linear association between the SII and HL. Subgroup analysis was conducted to explore the correlation between the SII and HL across different sexes. Results: Univariate logistic regression analysis revealed no significant correlation between the SII and the occurrence of hearing loss or SFHL (p>0.05), but there was a correlation between the SII and HFHL. Multivariate logistic regression revealed a significant positive correlation between the third quartile of the SII and hearing loss. In the second quartile, there was a significant positive correlation between the SII and SFHL. For HFHL, a significant positive correlation between the SII and HFHL was present only in the crude model and in the second and third quartiles. Stratified analysis of clinical variables revealed a positive correlation between SII and the onset of hearing loss in those with never alcohol intake and moderate alcohol intake, a positive correlation between the SII and HFHL in those with moderate alcohol intake,and a negative correlation between the SII and SFHL in those with a normal BMI, aged older than 60 years, and who were former smokers. In the RCSplot, a reverse U-shaped association was observed between the SII and the prevalence of hearing loss and SFHL (nonlinear p<0.05). There was a positive correlation between the SII and the incidence of HFHL. After stratification by sex, the SII showed a reverse U-shaped association with hearing loss in males and a positive correlation in females. Conclusion: The SII is positively correlated with HFHL and shows a potential U-shaped relationship with HL and SFHL. In males, there was a reverse U-shaped association between the SII and hearing loss, while in females, there was a positive correlation.

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Section: Discussionmentioning

confidence: 96%

“…The greater the SII is, the worse the therapeutic effect is for such patients 20 . Yuting Yao et al also showed that the immune and in ammatory response of the cochlea may be the common pathophysiology of all patients with SSNHL 19 . In this immune response, the presence of macrophages in the cochlea plays a very important role.…”

Section: Discussionmentioning

confidence: 99%

Association of systemic inflammatory biomarkers with hearing loss: Results from NHANES 1999–2020 analyses

Wang,

He,

Huang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Elias et al studied plasma malondialdehyde (MDA) activity in patients with SSNHL from the perspective of oxidative stress and studied the role of MDA in the prognosis of sudden deafness (34). Yao et al studied inflammatory indexes in the peripheral blood of patients with SSNHL by using different audiogram shapes (35). Feng et al investigated serum albumin and bone turnover biomarkers as potential prognostic markers for SSNHL (36,37).…”

Section: Discussionmentioning

confidence: 99%

Differentially expressed miRNA profiles of serum-derived exosomes in patients with sudden sensorineural hearing loss

Zhang

Yang

et al. 2023

Front. Neurol.

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ObjectivesThis study aimed to compare the expressed microRNA (miRNA) profiles of serum-derived exosomes of patients with sudden sensorineural hearing loss (SSNHL) and normal hearing controls to identify exosomal miRNAs that may be associated with SSNHL or serve as biomarkers for SSNHL.MethodsPeripheral venous blood of patients with SSNHL and healthy controls was collected to isolate exosomes. Nanoparticle tracking analysis, transmission electron microscopy, and Western blotting were used to identify the isolated exosomes, after which total RNA was extracted and used for miRNA transcriptome sequencing. Differentially expressed miRNAs (DE-miRNAs) were identified based on the thresholds of P < 0.05 and |log2fold change| > 1 and subjected to functional analyses. Finally, four exosomal DE-miRNAs, including PC-5p-38556_39, PC-5p-29163_54, PC-5p-31742_49, and hsa-miR-93-3p_R+1, were chosen for validation using quantitative real-time polymerase chain reaction (RT-qPCR).ResultsExosomes were isolated from serum and identified based on particle size, morphological examination, and expression of exosome-marker proteins. A total of 18 exosomal DE-miRNAs, including three upregulated and 15 downregulated miRNAs, were found in SSNHL cases. Gene ontology (GO) functional annotation analysis revealed that target genes in the top 20 terms were mainly related to “protein binding,” “metal ion binding,” “ATP binding,” and “intracellular signal transduction.” Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed that these target genes were functionally enriched in the “Ras,” “Hippo,” “cGMP-PKG,” and “AMPK signaling pathways.” The expression levels of PC-5p-38556_39 and PC-5p-29163_54 were significantly downregulated and that of miR-93-3p_R+1 was highly upregulated in SSNHL. Consequently, the consistency rate between sequencing and RT-qPCR was 75% and sequencing results were highly reliable.ConclusionThis study identified 18 exosomal DE-miRNAs, including PC-5p-38556_39, PC-5p-29163_54, and miR-93-3p, which may be closely related to SSNHL pathogenesis or serve as biomarkers for SSNHL.

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The Predictive Value of NLR, PLR and SII for SSNHL in Children and Young Adults

Liu,

Ma,

et al. 2024

Indian J Otolaryngol Head Neck Surg

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Inflammatory Indicators in Peripheral Blood in Sudden Sensorineural Hearing Loss Patients With Different Audiogram Shapes

Cited by 3 publications

References 33 publications

Association of systemic inflammatory biomarkers with hearing loss: Results from NHANES 1999–2020 analyses

Association of systemic inflammatory biomarkers with hearing loss: Results from NHANES 1999–2020 analyses

Differentially expressed miRNA profiles of serum-derived exosomes in patients with sudden sensorineural hearing loss

The Predictive Value of NLR, PLR and SII for SSNHL in Children and Young Adults

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