Inflammatory Markers and Incident Heart Failure in Older Men: the Role of Nt-Probnp

McKechnie, Douglas G J; Papacosta, AO; Lennon, Lucy; Welsh, Paul; Whincup, Peter H.; Wannamethee, S. Goya

doi:10.2217/bmm-2020-0669

Cited by 16 publications

(12 citation statements)

References 66 publications

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“…There are many clinical scoring and biomarkers that are used to determine the prognosis in post-MI patients. Related studies have been carried out separately for each other marker which was used, in our study, and it has been determined that these markers can provide with valuable prognostic information [13], [14], [15], [16], [17], [18], [19]. In a recently published study on association between NT-proBNP and 12 months MACE in NSTEMI patients, it was concluded that NT-proBNP represents a long-term prognostic biomarker for high-risk MACE in the first 12 months after NSTEMI, especially for older patients and those with reduced LVEF [14].…”

Section: Discussionmentioning

confidence: 99%

“…Khan states that a multibiomarker approach improves cardiac risk prediction, stratification, including MACE after MI [15]. Recently published study, set to determine the relationship between inflammation, natriuretic peptides, and incident HF in older men [16], suggests that increased levels of NT-proBNP are associated with markers of inflammation and the risk of HF. According to Oleynikov et al, increased levels of NT-proBNP are prognostic factors for HF progression in patients surviving STEMI [18].…”

Section: Discussionmentioning

confidence: 99%

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Incremental Value of Cardiac Biomarkers in Mid-term Prognosis of Patients with Acute Coronary Syndrome

Serafimov

Donevski

Ilova³

et al. 2022

Open Access Maced J Med Sci

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Background: Given the number of prognostic studies, both short- and long-termed, in patients with myocardial infarction (MI), the data on predicting major adverse cardiac events (MACE) following discharge still remains limited. Aim: to identify early predictors of MACE in MI patients, that underwent Primary Percutaneous Coronary Intervention (pPCI), with special emphasis on multiple cardiac biomarkers. Materials and methods: we analysed clinical, LV functional, angiographic variables, as well cardiac troponin, a marker of myocardial necrosis, natriuretic peptide (NT-proBNP), a marker of myocardial stress, and white blood cells (WBC), as a marker of inflammation. The study population were 150 consecutive patients treated for acute myocardial infarction. Results: The average follow-up period was 31 months. In total, 26 patients suffered from at least one MACE. Multivariate logistic regression analysis identified several independent predictors: NT-proBNP (p=0,07), number of diseased vessels (p=0,027), and need for loop diuretic therapy (p=0,050). ROC curve demonstrated excellent discriminatory function for MACE of NT-proBNP and WBC (area under the curve .640, and .658, p=0.025 and 0.011 respectively). Conclusion: The combination of biomarkers for myocardial stress and inflammation improves the prediction of major adverse cardiac events in MI survivors. Keywords: myocardial infarction, cardiac biomarkers, cardiac troponin, natriuretic peptide, prognosis, major adverse cardiac events (MACE), cardiac death

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Incremental Value of Cardiac Biomarkers in Mid-term Prognosis of Patients with Acute Coronary Syndrome

Serafimov

Donevski

Ilova³

et al. 2022

Open Access Maced J Med Sci

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“…NT-proBNP i hs-CRP su povezani sa drugim inflamatornim biomarkerima, kao što su IL-6 i pojava srčane insuficijencije kod starijih muškaraca [20,21].…”

Section: Discussionunclassified

“…NT-proBNP and hs-CRP are linked to other inflammatory biomarkers, such as IL-6 and heart failure in older men [20,21].…”

Section: Biomarkerimentioning

confidence: 99%

Major vascular surgery in the geriatric population: Cardiac risk stratification

Perić¹,

Stošić²,

Stojanović³

et al. 2022

Srpski medicinski časopis Lekarske komore

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Reliance on surgery, improvements in surgical techniques, and perioperative management have led to a dramatic increase in the frequency of surgical procedures in the elderly population. According to the European Society of Cardiology and the European Society of Anaesthesiology and Intensive Care, major vascular surgery is defined as high-risk, considering the frequency of myocardial infarction and cardiac arrest, which is higher than 5%. Age is an independent predictor of myocardial infarction and cardiac arrest. Heart function alterations are primary changes that occur with advancing age. Risk stratification represents a set of procedures that include identifying chronic systemic diseases, determining their severity, stability and the need for further evaluation and/or therapy optimization, with the aim of reducing perioperative and postoperative mortality and morbidity. In addition to the application of risk scores, accurate risk stratification requires the combined application of both preoperative and postoperative biomarkers. The main idea of integrating biomarkers with scoring systems is to reveal those patients with clinically unmanifested disease, who carry a mortality risk and remain undetected by scoring systems. Biomarkers, such as NT-proBNP and highly sensitive C-reactive protein, have the greatest predictive influence in geriatric vascular surgery.

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“…In the literature, it is stated that chronic activation of the immune system plays a central role in the occurrence and progression of HF with reduced ejection fraction and HF with preserved ejection fraction (5). It has been shown that there is a correlation between inflammation and adverse cardiovascular events in patients with HF, and inflammation plays a prominent role in both acute and chronic heart failure (1).…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Recurrent Hospitalization and Inflammation in Heart Failure Patients

Kaya

Akkaya

et al. 2023

ODÜ Tıp Dergisi

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Aim: In this study, we aimed to show whether there is a relationship between inflammatory markers and recurrent hospitalizations within 1 year in patients with heart failure. Material and Method: Patients over the age of 18 who were followed up with a diagnosis of heart failure in the cardiology outpatient clinic between 2020-2021 were included in the study.The files of the patients were scanned and their sociodemographic characteristics, hemogram and biochemical parameters were recorded. Platelet lymphocyte ratio (P/L), neutrophil lymphocyte ratio (N/L), monocyte HDL (monocyte/HDL) ratios were calculated from inflammatory markers. It was screened how many times the patients were hospitalized and followed up in the hospital in the last year. The correlation between the number of hospitalizations and inflammatory markers were evaluated. Results: 483 patients were included in the study. The mean age of the patients was 65.65±11.75 years. The mean ejection fraction of the patients was found to be 29.53±6.102% (minimum 15 and maximum 45). CRP=8.01±9.29, monocyte HDL ratio=0.0172±0.010, platelet-lymphocyte ratio=149.24±88.80, neutrophil-lymphocyte ratio=4.54±4.88.It was determined that 73 (15.1%) of the patients had recurrent hospitalizations within one year. A significant positive correlation was found between recurrent hospitalizations and monocyte HDL ratio (r= 0.123, p=0.007), but no significant correlation was found with other parameters. Conclusion: A significant positive correlation was found between recurrent hospitalizations and only monocyte HDL ratio. No significant correlation was found between other inflammatory markers. Larger studies with a large number of cases are needed to evaluate the relationship between recurrent hospitalization and inflammation

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Inflammatory Markers and Incident Heart Failure in Older Men: the Role of Nt-Probnp

Cited by 16 publications

References 66 publications

Incremental Value of Cardiac Biomarkers in Mid-term Prognosis of Patients with Acute Coronary Syndrome

Incremental Value of Cardiac Biomarkers in Mid-term Prognosis of Patients with Acute Coronary Syndrome

Major vascular surgery in the geriatric population: Cardiac risk stratification

The Relationship between Recurrent Hospitalization and Inflammation in Heart Failure Patients

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