Inflammatory Markers and Risk of Heart Failure With Reduced to Preserved Ejection Fraction

Albar, Zainab; Albakri, Marwah; Hajjari, Jamal; Karnib, Mohamad; Janus, Scott E.; Al‐Kindi, Sadeer G.

doi:10.1016/j.amjcard.2021.11.045

Cited by 26 publications

(20 citation statements)

References 27 publications

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“…This phenotype corresponds with the described HFpEF phenotype [ 31 ]. Cluster 1 achieved the highest concentration of selected inflammatory biomarkers (IL-6, ferritin), and high activation of inflammatory pathways was reported to be unique for the HFpEF [ 32 ]. Recent studies showed that higher osmolarity correlates with the incidence of WRF in AHF [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Machine Learning Approach to Understand Worsening Renal Function in Acute Heart Failure

et al. 2022

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Acute heart failure (AHF) is a common and severe condition with a poor prognosis. Its course is often complicated by worsening renal function (WRF), exacerbating the outcome. The population of AHF patients experiencing WRF is heterogenous, and some novel possibilities for its analysis have recently emerged. Clustering is a machine learning (ML) technique that divides the population into distinct subgroups based on the similarity of cases (patients). Given that, we decided to use clustering to find subgroups inside the AHF population that differ in terms of WRF occurrence. We evaluated data from the three hundred and twelve AHF patients hospitalized in our institution who had creatinine assessed four times during hospitalization. Eighty-six variables evaluated at admission were included in the analysis. The k-medoids algorithm was used for clustering, and the quality of the procedure was judged by the Davies–Bouldin index. Three clinically and prognostically different clusters were distinguished. The groups had significantly (p = 0.004) different incidences of WRF. Inside the AHF population, we successfully discovered that three groups varied in renal prognosis. Our results provide novel insight into the AHF and WRF interplay and can be valuable for future trial construction and more tailored treatment.

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Section: Discussionmentioning

confidence: 99%

Machine Learning Approach to Understand Worsening Renal Function in Acute Heart Failure

et al. 2022

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“…Наличие ВИЧ-инфекции, особенно при наркопотреблении, взаимосвязано с риском бактериальных и грибковых инфекций [19]. В наблюдательном исследовании MESA (Multi-Ethnic Study of Atherosclerosis) среди 6814 больных без ХСН в анамнезе при наблюдении в течение 10,9 лет было определено, что ФР воспаления, такие как интерлейкин-6, фактор некроза опухоли альфа, С-реактивный белок, взаимосвязаны с риском развития ХСН [20]. В нашем исследовании было подтверждено, что и у больных ВИЧ-инфекцией наличие острых или обострение хронических воспалительных заболеваний явилось ФР ХСН.…”

Section: Discussionunclassified

Risk factors and diagnostic value of urinary N-terminal pro-brain natriuretic peptide for verification of heart failure in human immunodeficiency virus-infected patients

Goryacheva

Козиолова

2022

Russ J Cardiol

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Aim. To determine the risk factors and diagnostic value of urinary N-terminal probrain natriuretic peptide (NT-proBNP) for verification of heart failure in human immunodeficiency virus (HIV)-infected patientsMaterial and methods. This cross-sectional screening clinical trial included 115 HIV-infected patients who were hospitalized during 24 months. The patients were divided into 2 groups, depending on the data suggestive of HF and the blood and urinary NT-proBNP concentration. So, group 1 included 69 HIV-infected patients with HF symptoms and increased blood and urinary NTproBNP, while group 2 — 46 HIV-infected patients not meeting HF criteria. NTproBNP concentration was determined on Immulite 1000 Immunoassay System (DPC, USA) in blood plasma and frozen urine using Vector Best reagents (Russia).Results. Correlation analysis revealed a significant direct moderate correlation between blood and urinary NT-proBNP in the entire cohort of studied patients (r=0,367; p<0,05). Urinary NT-proBNP ≥8,6 pg/ml ml is diagnostic for HF verification in HIV-infected patients. Significant differences between the groups were obtained in the incidence of ventricular arrhythmias, viral hepatitis B and C, liver cirrhosis, infective endocarditis, other inflammatory diseases, thrombocytopenia, left ventricular (LV) diastolic dysfunction and its severity. In addition, there were differences in LV mass index, left atrial volume index, incidence of LV hypertrophy and left atrial enlargement, concentration of hemoglobin and CD4 cells <200 in 1 µl. The preserved LV ejection fraction was detected significantly more often (p<0,001). Conclusion. In HIV-infected patients, blood plasma and urinary NT-proBNP concentration correlates with each other. Urinary NT-proBNP ≥8,6 pg/ml is diagnostic for HF verification in HIV-infected patients. Risk factors and features of developing HF, estimated by NT-proBNP concentration in frozen urine in HIV-infected patients, are comparable to data obtained from blood plasma NTproBNP.

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“…In CHF patients we did not also find significant correlations between blood adipocytokines, LDL, and CRP concentrations, both in whole study population and the study groups (CHF patients and controls separately). However, it is known that a combination of elevated levels of both LDL cholesterol and CRP is the risk factor for endothelial dysfunction, progression of ischemic heart failure [2-5, 12, 17, 21-29], and unfavorable outcomes, including mortality and readmission, especially in men [30] and in CHF patients with preserved LVEF [25,31]. On the other hand, lower, rather than higher, blood LDL cholesterol concentration was related to a poor prognosis in CHF patients and other advanced diseases requiring hospitalization, which is known as the "cholesterol paradox" [32].…”

Section: Discussionmentioning

confidence: 99%

Selected adipocytokine concentrations in patients hospitalized for exacerbated chronic heart failure

Wawrzeńczyk

Anaszewicz

Szukay

et al. 2022

Medical Research Journal

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Introduction:The role of adipose tissue as energy storage and endocrine organ is an area of interest in the treatment of several diseases. This study aimed to to evaluate blood adiponectin (ADP), leptin, tumor necrosis factor type alpha (TNF-alpha) concentrations, and their prognostic value in patients with exacerbated chronic heart failure (CHF). Methods and results:The following were assessed in 64 consecutive patients hospitalized for exacerbated CHF and a control group of 32 age and sex-matched individuals admitted due to life-limiting symptoms of peripheral artery disease: serum leptin, ADP, TNF-alpha concentrations, and body composition determined by bioelectrical impedance analysis. Compared to the control group, CHF patients had significantly higher blood ADP concentrations, a higher ratio of ADP to fat mass expressed as a percentage of body mass, and lower blood TNF-alpha concentrations and ratios of TNF-alpha to the visceral fat level (VFL). Compared to patients who survived, patients with CHF who died during the one-year follow-up had significantly higher values of ADP and higher ratios of ADP to body surface area. In the Cox regression model, blood ADP concentration was the only independent risk factor in respect of all-cause mortality during the one-year follow-up (HR; 95% CI: 1.16; 1.03-1.31).Conclusions: Patients with CHF present dysregulation in the secretion of ADP and TNF-alpha. Increased blood ADP concentration was associated with an increase in one-year all-cause mortality by 16%.

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Inflammatory Markers and Risk of Heart Failure With Reduced to Preserved Ejection Fraction

Cited by 26 publications

References 27 publications

Machine Learning Approach to Understand Worsening Renal Function in Acute Heart Failure

Machine Learning Approach to Understand Worsening Renal Function in Acute Heart Failure

Risk factors and diagnostic value of urinary N-terminal pro-brain natriuretic peptide for verification of heart failure in human immunodeficiency virus-infected patients

Selected adipocytokine concentrations in patients hospitalized for exacerbated chronic heart failure

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