Inflammatory Markers and Risk of Developing Type 2 Diabetes in Women

Hu, Frank B.; Meigs, James B.; Li, Tricia Y.; Rifai, Nader; Manson, JoAnn E.

doi:10.2337/diabetes.53.3.693

Cited by 709 publications

(557 citation statements)

References 53 publications

Supporting

Mentioning

511

Contrasting

Unclassified

Order By: Relevance

“…Previous studies, including analyses from the JHS, have observed a positive relationship between hs‐CRP (biomarker of inflammation) and incident diabetes mellitus 13, 29. However, this association was largely explained by measures of obesity including BMI and WC.…”

Section: Discussionmentioning

confidence: 99%

High‐Intensity Cigarette Smoking Is Associated With Incident Diabetes Mellitus In Black Adults: The Jackson Heart Study

White

Cain

Benjamin

et al. 2018

JAHA

View full text Add to dashboard Cite

BackgroundPrevious reports on whether smoking is associated with insulin resistance and diabetes mellitus have yielded inconsistent findings. We aimed to evaluate the relationship between cigarette smoking and incident diabetes mellitus in the Jackson Heart Study.Methods and ResultsJackson Heart Study participants enrolled at baseline without prevalent diabetes mellitus (n=2991) were classified by self‐report as current smokers, past smokers (smoked ≥400 cigarettes/life and no longer smoking), or never smokers. We quantified smoking intensity by number of cigarettes smoked daily; we considered ≥20 cigarettes per day (1 pack) “high‐intensity.” We defined diabetes mellitus as fasting glucose ≥126 mg/dL, hemoglobin A1c ≥6.5% or International Federation of Clinical Chemistry units HbA1c 48 mmol/mol, or use of diabetes mellitus medication. We estimated the adjusted associations of smoking status, intensity, and dose (pack‐years) with incident diabetes mellitus using Poisson regression models. At baseline there were 361 baseline current (1–10 cigarettes per day [n=242]; ≥20 [n=119]), 502 past, and 2128 never smokers. From Visit 1 to Visit 3 (mean 8.0±0.9 years), 479 participants developed incident diabetes mellitus. After adjustment for covariates, baseline current smokers who smoked less than a pack/d and past smokers had similar rates of incident diabetes mellitus compared with never smokers (incidence rate ratios 1.04, 95% confidence interval, 0.69–1.58 and 1.08, 95% confidence interval, 0.82–1.42, respectively). Baseline current high‐intensity smokers had a 79% (95% confidence interval, 1.14–2.81) higher incidence of diabetes mellitus compared with never smokers. Smoking dose (per 10 pack‐years) was also associated with a higher incidence of diabetes mellitus (incidence rate ratios 1.10, 95% confidence interval, 1.03–1.19) in adjusted models.ConclusionsHigh‐intensity cigarette smoking and smoking pack‐years are associated with an increased risk of developing diabetes mellitus in blacks.

show abstract

Section: Discussionmentioning

confidence: 99%

High‐Intensity Cigarette Smoking Is Associated With Incident Diabetes Mellitus In Black Adults: The Jackson Heart Study

White

Cain

Benjamin

et al. 2018

JAHA

View full text Add to dashboard Cite

show abstract

“…Results suggest that IL-6 and TNF-α-R levels may be more sensitive to dietary fiber intake than hs-CRP levels in postmenopausal women. A growing body of evidence connects inflammation with increased risk for atherosclerosis [1][2][3][4][5][6], type 2 diabetes [11,13], and cancer [14,15], but much less is known about the role of diet in inflammation. Most studies to date have focused on the relationship between hs-CRP and diet as well as other lifestyle variables, however, two previous studies have found that IL-6 and TNF-α levels may be stronger predictors of incident cardiovascular events than hs-CRP level [43,44].…”

Section: Discussionmentioning

confidence: 99%

“…High sensitivity serum C-reactive protein (hs-CRP), plasma interleukin 6 (IL-6), and tumor necrosis factor α receptor 2 (TNF-α-R2) are markers of systemic inflammation in the body, and have been associated with many chronic diseases, including coronary heart disease (CHD) [1][2][3][4][5][6], metabolic syndrome [7][8][9], diabetes mellitus [10][11][12][13], and cancer [14,15].…”

Section: Introductionmentioning

confidence: 99%

Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study

et al. 2008

View full text Add to dashboard Cite

Objective-Systemic inflammation may play an important role in the development of atherosclerosis, type 2 diabetes, and some cancers. Few studies have comprehensively assessed the direct relationships between dietary fiber and inflammatory cytokines, especially in minority populations. Using baseline data from 1,958 postmenopausal women enrolled in the Women's Heath Initiative Observational Study, we examined cross-sectional associations between dietary fiber intake and markers of systemic inflammation (including serum C-reactive protein (hs-CRP), interleukin 6 (IL-6), and tumor necrosis factor α receptor 2 (TNF-α-R2)), as well as differences in these associations by ethnicity.Method-Multiple linear regression models were used to assess the relationship between fiber intake and makers of systemic inflammation.Results-After adjustment for covariates, intake of dietary fiber were inversely associated with both IL-6 (P values for trend were 0.01 for total fiber, 0.004 for soluble fiber, and 0.001 for insoluble fiber) and TNF-α-R2 (P values for trend were 0.002 for total, 0.02 for soluble, and <0.001 for insoluble fiber). Although the sample sizes were small in minority Americans, results were generally Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusions-These findings lend support to the hypothesis that a high-fiber diet is associated with lower plasma levels of IL-6 and TNF-α-R2. Contrary to previous reports, however, there was no association between fiber and hs-CRP among postmenopausal women. Future studies on the influence of diet on inflammation should include IL-6 and TNF-α-R2 and enroll participants from ethnic minorities. NIH Public Access

show abstract

“…There is heterogeneity between studies, with some demonstrating an independently positive association of CRP with incident diabetes [3][4][5][6][7][8][9][10][11], while others show no association after adjustment for adiposity and insulin resistance [12][13][14][15]. Differences in the association between CRP and diabetes by sex have also been reported [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis

et al. 2009

View full text Add to dashboard Cite

Aims/hypothesis We examined the association between serum C-reactive protein (CRP) and incident diabetes in a prospective study, and added these data to a literature-based meta-analysis to explore potential sources of heterogeneity between studies. Methods We analysed a case-control study nested within the European Prospective Investigation of Cancer (EPIC)-Norfolk cohort, including 293 incident diabetes cases and 708 controls. We combined 16 published studies on CRP and incident diabetes in a random-effect meta-analysis. Results In the EPIC-Norfolk cohort, serum CRP was associated with a higher risk of diabetes after adjusting for age, sex, BMI, family history of diabetes, smoking and physical activity (OR 1.49, comparing the extreme thirds of CRP distribution [95% CI 1.03-2.15], p=0.03). However, the association was completely attenuated after further adjustment for WHR, serum γ-glutamyltransferase and serum adiponectin (OR 1.00; 95% CI 0.66-1.51, p=1.0). In a meta-analysis of 16 published studies with 3,920 incident diabetes cases and 24,914 controls, the RR was 1.72 (95% CI 1.54-1.92), comparing the extreme thirds of CRP distribution, with substantial heterogeneity between studies (I 2 =52.8%, p=0.007). Conclusions/interpretation Initial evidence of association between CRP and incident diabetes was confounded by central adiposity, markers of liver dysfunction and adiponectin in the primary analysis. Despite an overall positive association in the meta-analysis, considerable heterogeneity existed between studies. The degree of adjustment for central adiposity and baseline glycaemia explained some of this heterogeneity and suggests that CRP may not be an independent risk factor for type 2 diabetes.

show abstract

Inflammatory Markers and Risk of Developing Type 2 Diabetes in Women

Cited by 709 publications

References 53 publications

High‐Intensity Cigarette Smoking Is Associated With Incident Diabetes Mellitus In Black Adults: The Jackson Heart Study

High‐Intensity Cigarette Smoking Is Associated With Incident Diabetes Mellitus In Black Adults: The Jackson Heart Study

Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study

Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis

Contact Info

Product

Resources

About