Inflammatory markers are associated with cardiac autonomic dysfunction in recent-onset type 2 diabetes

Herder, Christian; Schamarek, Imke; Nowotny, Bettina; Carstensen‐Kirberg, Maren; Straßburger, Klaus; Nowotny, Peter; Kannenberg, Julia M.; Strom, Alexander; Püttgen, Sonja; Müssig, Karsten; Szendroedi, Julia; Roden, Michael; Ziegler, Dan

doi:10.1136/heartjnl-2015-309181

Cited by 60 publications

(47 citation statements)

References 30 publications

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“…Previous clinical trials have confirmed the association of inflammatory biomarkers with CAN in patients with recently diagnosed T2DM. However, there was no clear association between CAN and IL-6 in this group of patients 29 . A considerable weakness of this study is the limited number of the participants.…”

Section: Discussioncontrasting

confidence: 58%

Specific gene expression in type 1 diabetic patients with and without cardiac autonomic neuropathy

Gastoł

Polus

Biela

et al. 2020

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transduction 11. The induction of gp130 family of cytokines parallel axonal injury, in the experimentally induced diabetic mice, significantly decreased axonal regeneration 12. This study's goal is to follow, by microarray, the possible alteration of blood cell molecular pathways which may be altered to initiate the process of nervous tissue destruction in the course of T1D. Material and Methods Patients were selected from those attending the diabetic clinic at JUMC Department of Metabolic Disorders. The study group consisted of 60 patients with T1D, confirmed with a positive anti-GAD test result. These patients were treated with a standard therapeutic regimen: multiple daily injections (MDI) or continuous subcutaneous insulin infusions (CSII). The patients were randomized into two subgroups depending on the presence or absence of symptoms of autonomic neuropathy. The control group (n = 20) consisted of healthy non-obese volunteers recruited in accordance to age, gender and body weight. The exclusion criteria for all participants were: age under 20 and above 65 years; metabolic syndrome, cardiovascular diseases, cancer, chronic inflammation; severe liver or kidney failure, iron deficiency anaemia; pregnancy, breast feeding, hormone replacement therapy; anticoagulant treatment; usage of anti-inflammatory drugs and lack of the patient's written consent to participate in the study. The study protocol was approved by the Jagiellonian University Bioethical Committee and was in accordance with the Declaration of Helsinki. Informed consent was obtained from all individual participants included in the study. Evaluation of autonomic neuropathy (CAN). The presence of CAN was based on the outcome of the reference method using the ProSciCard apparatus (Ewing test) 13. The severity of the cardiovascular neuropathy in the investigated group was determined by the number of abnormal results (from 3 up to 5) of Ewing test and pathological blood pressure variability [the guidelines for 2018 year of Polish Society of Diabetes] 13. Fasting venous blood was sampled from each participant for further tests. Part of the sample was sent for a routine laboratory diagnostic test, and another part was immediately centrifuged for serum isolation, and then transferred into sterile eppendorfs and stored at −20 °C. Whole blood samples were collected for mRNA isolation using PAXgene Blood RNA Tubes (Becton Dickinson) for material stabilization and transport. Each study participant underwent laboratory tests assessing the level of metabolic control, including: HbA1c level, lipidogram, renal markers, liver function tests and TSH levels. Biochemical tests were performed at the main Laboratory Diagnostics Department in the University Hospital, in accordance with standard procedures. RNA isolation. Purification of total RNA from human whole blood was performed using the PAXgene Blood RNA Kit, following producer protocol. The RNA quality was analysed using the Tapestation 2200 instrument (Agilent, USA) and quantified by spectrophotometry on the NanoDrop

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Section: Discussioncontrasting

confidence: 58%

Specific gene expression in type 1 diabetic patients with and without cardiac autonomic neuropathy

Gastoł

Polus

Biela

et al. 2020

Sci Rep

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“…A possible explanation for this response is the larger pro-inflammatory state compared to their normal weight counterparts [14,27,28]. Different inflammatory markers, such as C-reactive protein [29][30][31], leukocyte [31,32], and leptin [33] are inversely associated with HRV. Another explanation for these results involve the volume and intensity of physical activities performed by adolescents.…”

Section: Discussionmentioning

confidence: 99%

Physical Activity and Heart Rate Variability in Adolescents with Abdominal Obesity

et al. 2017

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Physical activity is a protective factor for autonomic dysfunction. However, whether this occurs in adolescents with abdominal obesity is still unclear. Thus, the aim of this study was to analyze the association between physical activity and heart rate variability (HRV) in adolescents with and without abdominal obesity. This cross-sectional study included 1152 boys (age: 17 ± 1 years). HRV measures of time (root mean square of the squared differences between adjacent normal RR intervals-RMSSD and the percentage of adjacent intervals over 50 ms-PNN50) and frequency domains (balance sympathetic-vagal-LF/HF) were evaluated, as well as total physical activity, commuting physical activity, leisure-time physical activity, and abdominal obesity. All physical activity domains were associated with better RMSSD, PNN50, and LF/HF in normal weight adolescents (p < 0.05), whereas in adolescents with abdominal obesity only leisure-time physical activity was associated with better PNN50 (b = 0.174, p = 0.035) independent of age, period of the day, body mass index, and blood pressure. In conclusion, higher leisure-time physical activity, but not total and commuting physical activity levels, was associated with improved HRV in adolescents with abdominal obesity.

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“…In the current study, CRF and HRV were determined in 163 patients with type 1 diabetes and compared with 40 age-matched glucose-tolerant control subjects (control 1), and 188 patients with type 2 diabetes were compared with another 40 control subjects (control 2) ( Table 1). Participants , and LF/HF ratio as previously described (25).…”

Section: Participantsmentioning

confidence: 99%

Differential Patterns of Impaired Cardiorespiratory Fitness and Cardiac Autonomic Dysfunction in Recently Diagnosed Type 1 and Type 2 Diabetes

et al. 2016

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Inflammatory markers are associated with cardiac autonomic dysfunction in recent-onset type 2 diabetes

Abstract: Biomarkers of inflammation were differentially associated with diminished cardiac autonomic dysfunction in recent-onset type 2 diabetes.

Cited by 60 publications

References 30 publications

Specific gene expression in type 1 diabetic patients with and without cardiac autonomic neuropathy

Specific gene expression in type 1 diabetic patients with and without cardiac autonomic neuropathy

Physical Activity and Heart Rate Variability in Adolescents with Abdominal Obesity

Differential Patterns of Impaired Cardiorespiratory Fitness and Cardiac Autonomic Dysfunction in Recently Diagnosed Type 1 and Type 2 Diabetes

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