Inflammatory markers as correlates of body composition and grip strength among adults with and without HIV: A cross-sectional study in Ethiopia

Hegelund, Maria Hein; Faurholt‐Jepsen, Daniel; Abdissa, Alemseged; Yilma, Daniel; Andersen, Anita Sylvest; Christensen, Dirk L.; Wells, Jonathan C. K.; Friis, Henrik; Girma, Tsinuel; Olsen, Mette Frahm

doi:10.1038/s41430-021-01056-4

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…Reduced muscle function in the context of this study may arise from malnutrition and/or chronic inflammation [12]. In addition, myofiber atrophy occurs in vitamin D deficiency, which is more common in HIV infection [41].…”

Section: Discussionmentioning

confidence: 93%

“…Studies of HIV in adults report impaired muscle function [8,9]; however, few studies, particularly in Africa, have investigated muscle function in CWH. Those reported are often small, lack a control population [10,11], or focus on treatment-naive individuals [12]. A recent systematic review of just five cross-sectional studies (none in Africa), totalling 197 adolescents (age 16-18 years) living with HIV, identified reduced muscle strength and physical fitness compared with uninfected peers [13].…”

Section: Introductionmentioning

confidence: 99%

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Perinatal HIV infection is associated with deficits in muscle function in children and adolescents in Zimbabwe

Gregson,

Rehman,

Rukuni

et al. 2023

Aids

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Objectives: :To determine how muscle strength, power, mass, and density (i.e. quality) differ between children living with HIV (CWH) and those uninfected, and whether antiretroviral therapy (ART) regime is associated with muscle quality. Design: :A cross-sectional study in Harare, Zimbabwe. Methods: :The study recruited CWH aged 8–16years, taking ART for ≥2years, from HIV clinics, and HIV-uninfected children from local schools. Muscle outcomes comprised grip strength measured by hand-held Jamar dynamometer, lower-limb power measured by standing long-jump distance, lean mass measured by dual-energy X-ray absorptiometry, and muscle density (reflecting intramuscular fat) by peripheral quantitative computed tomography. Linear regression calculated adjusted mean differences (aMD) by HIV status. Results: :Overall, 303 CWH and 306 without HIV, had mean(SD) age 12.5(2.5) years, BMI 17.5(2.8), with 50% female. Height and fat mass were lower in CWH, mean differences(SE) 7.4(1.1)cm and 2.7(0.4)kgs, respectively. Male CWH had lower grip strength (aMD 2.5[1.1,3.9]kg, P < 0.001), long-jump distance (7.1[1.8,12.5]cm, P = 0.006), muscle density (0.58[0.12,1.05]mg/cm3, P = 0.018, but not lean mass 0.06[-1.08,1.21]kg, P = 0.891) versus boys without HIV; differences were consistent but smaller in females. Mediation analysis suggested the negative effect of HIV on jumping power in males was partially mediated by muscle density (P = 0.032). CWH taking tenofovir disoproxil fumarate (TDF) had lower muscle density (0.56[0.00,1.13]mg/cm3, P = 0.049) independent of fat mass, than CWH on other ART. Conclusions: :Perinatally-acquired HIV is associated, particularly in males, with reduced upper and lower-limb muscle function, not mass. Intra-muscular fat (poorer muscle quality) partially explained reductions in lower-limb function. TDF is a novel risk factor for impaired muscle quality.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Perinatal HIV infection is associated with deficits in muscle function in children and adolescents in Zimbabwe

Gregson,

Rehman,

Rukuni

et al. 2023

Aids

View full text Add to dashboard Cite

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Sarcopenia risk, sarcopenia-related quality of life, and associated factors in people living with human immunodeficiency virus (HIV): A web-based survey

Quaresma,

Vicente,

Balchiunas

et al. 2024

Nutrition

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Bone Mineral Density is Related to CD4+ T Cell Counts and Muscle Mass is Associated with B Cells in Common Variable Immunodeficiency Patients

de Melo,

Pereira,

Sini

et al. 2024

EMIDDT

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Background: Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by chronic/recurrent respiratory infections, bronchiectasis, autoimmunity, inflammatory, gastrointestinal diseases and malignancies associated with a chronic inflammatory state and increased risk of osteoporosis and muscle loss. Aim: The aim of this study was to evaluate bone mineral density (BMD), body composition and their relationship with lymphocyte subpopulations in CVID patients. Methods: Dual-energy X-ray absorptiometry was performed to assess BMD, lean mass, and fat mass in CVID patients. Peripheral blood CD4+, CD8+, and CD19+ cells were measured using flow cytometry. Results: Thirty-three patients (37.3 ± 10.8 years old) were examined. Although only 11.8% of the individuals were malnourished (BMI <18.5 kg/m2), 27.7% of them had low skeletal muscle mass index (SMI), and 57.6% of them had low BMD. Patients with osteopenia/osteoporosis presented lower weight (p=0.007), lean mass (p=0.011), appendicular lean mass (p=0.011), SMI (p=0.017), and CD4+ count (p=0.030). Regression models showed a positive association between CD4+ count and bone/muscle parameters, whereas CD19+ B cell count was only associated with muscle variables. Analysis of ROC curves indicated a cutoff value of CD4+ count (657 cells/mm3; AUC: 0.71, 95% CI 0.52-0.90) which was related to low BMD. Weight (p=0.004), lean mass (p=0.027), appendicular lean mass (p=0.022), SMI (p=0.029), total bone mineral content (p=0.005), lumbar (p=0.005), femoral neck (p=0.035), and total hip BMD (p<0.001) were found to be lower in patients with CD4+ count below the cutoff. Conclusion: CVID patients presented with low BMD, which was associated with CD4+ count. Moreover, low muscle parameters were correlated with B cell count.

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Inflammatory markers as correlates of body composition and grip strength among adults with and without HIV: A cross-sectional study in Ethiopia

Cited by 4 publications

References 32 publications

Perinatal HIV infection is associated with deficits in muscle function in children and adolescents in Zimbabwe

Perinatal HIV infection is associated with deficits in muscle function in children and adolescents in Zimbabwe

Sarcopenia risk, sarcopenia-related quality of life, and associated factors in people living with human immunodeficiency virus (HIV): A web-based survey

Bone Mineral Density is Related to CD4+ T Cell Counts and Muscle Mass is Associated with B Cells in Common Variable Immunodeficiency Patients

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