Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases

Mozoş, Ioana; Malainer, Clemens; Horbańczuk, J.O.; Gug, Cristina; Stoian, Dana; Luca, Constantin; Atanasov, A

doi:10.3389/fimmu.2017.01058

Cited by 283 publications

(249 citation statements)

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“…It is, also, possible that these relationships may not develop until a later age. Both of the measured markers in our study are significantly related to arterial stiffness markers in adults . Kapiotis et al found higher CRP and IL‐6 in obese and morbidly obese children.…”

Section: Discussionsupporting

confidence: 63%

“…This relationship continued to approach significance even when percent body fat was included in the model, indicating the relationship is not solely due to obesity. Increased white cell counts have been shown to predict arterial stiffness in adults in a variety of conditions and increased neutrophil counts predict future cardiovascular disease in adults . The increased neutrophil counts are thought to be evidence of increased endothelial inflammatory damage.…”

Section: Discussionmentioning

confidence: 99%

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Increased body fat and reduced insulin sensitivity are associated with impaired endothelial function and subendocardial viability in healthy, non‐Hispanic white adolescents

et al. 2019

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Background Cardiovascular disease has its origins in adolescents. Endothelial dysfunction, arterial stiffness, and decreased endocardial oxygen supply: demand ratios are early functional markers of cardiovascular risk. The goal of this study was to determine the relationships of these markers to physical, inflammatory, and metabolic markers in healthy non‐Hispanic, white adolescents. Methods Thirty‐four of the 75 subjects were female. Mean age was 15.0 ± 1.7 years and mean body mass index (BMI) was 22.0 ± 5.8 kg/m2 (mean ± SD). Reactive hyperemia was measured using venous occlusion plethysmography. Arterial tonometry was used to measure the augmentation index (AIx75) and the Buckberg subendocardial viability ratio. Blood samples were taken to measure inflammatory and lipid markers and oral glucose tolerance test was used to assess insulin sensitivity. Results Reactive hyperemia decreased as body mass and fat mass increased. It also decreased with increasing neutrophil count. The Buckberg index was higher in males and was positively related to insulin sensitivity even when accounting for age, sex, and resting heart rate. AIx75 was not related to any of the other variables. Conclusions These results demonstrate that increased fat mass and decreased insulin sensitivity are related to poorer vascular function and cardiac risk in adolescents before the development of actual cardiovascular disease.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Increased body fat and reduced insulin sensitivity are associated with impaired endothelial function and subendocardial viability in healthy, non‐Hispanic white adolescents

et al. 2019

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“…CRP is the only circulating biomarker related to vascular wall biology and increased levels of CRP are linearly associated with PWV and PWV index values . High levels of CRP are associated with arterial and aortic stiffness in hypertensive and type 2 diabetes patients . However, the direct etiological role of CRP in arterial dysfunction and atherosclerosis remains contradictory and would require other studies to better understand it …”

Section: Discussionmentioning

confidence: 99%

“…High levels of CRP are associated with arterial and aortic stiffness in hypertensive and type 2 diabetes patients . However, the direct etiological role of CRP in arterial dysfunction and atherosclerosis remains contradictory and would require other studies to better understand it …”

Section: Discussionmentioning

confidence: 99%

Application of a decision tree to establish factors associated with a nomogram of aortic stiffness

Vallée¹,

Safar²,

Blacher³

2019

J of Clinical Hypertension

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Aortic stiffness is a marker of vascular aging and may reflect occurrence of cardiovascular (CV) diseases. Aortic pulse wave velocity (PWV), a marker of aortic stiffness, can be measured by applanation tonometry. A nomogram of aortic stiffness was evaluated by the calculation of PWV index. Theoretical PWV can be calculated according to age, gender, mean blood pressure, and heart rate, allowing to form an individual PWV index [(measured PWV – theoretical PWV)/theoretical PWV]. The purpose of the present cross‐sectional study was to investigate the determinants of the PWV index, by applying a decision tree. A cross‐sectional study was conducted from 2012 to 2017, and 597 individuals were included. A training decision tree was constructed based on seventy percent of these subjects (N = 428). The remaining 30% (N = 169) were used as the testing dataset to evaluate the performance of the decision trees. The input variables for the models were clinical and biochemical parameters. The different input variables remained in the model were diabetes, tobacco status, carotid plaque, albuminuria, C‐reactive protein, total cholesterol, BMI, and previous CV diseases. For the validation decision model, the sensitivity, specificity, and accuracy values for identifying the related risk factors of PWV index were 70%, 78%, and 0.73. Since determinants of PWV index were all well‐accepted CV risk factors, a nomogram of aortic stiffness could be considered as an integrator of CV risk factors on their duration of exposure and could be utilized to develop future programs for CV risk assessment and reduction strategies.

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“…Low-grade inflammation, with a general activation of the innate immune system, can silently persist for a long time. It is thought to play a role in the pathogenesis of most agerelated diseases, such as Alzheimer's disease, atherosclerosis, cardiovascular disease, and diabetes [9][10][11][12].…”

mentioning

confidence: 99%

Relationship between CRP, systemic immune-inflammation index and routine hemogram related inflammatory markers in low grade inflammation

Üstündağ¹

2018

Int J Med Biochem

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Research ArticleR ecent advances in technology led to the quantitation of new parameters with automated hematology analyzers. Some of these parameters have been accepted as additional markers in diagnosing various clinical conditions [1][2][3][4][5]. They are cost effective and easier to perform in a routine setting than tests for some other markers. C-reactive protein (CRP) is a commonly used inflammation marker in both acute and chronic inflammation. Most healthy individuals have a CRP concentration of 3 mg/L or less; a CRP level higher than 10 mg/L indicates a clinically significant inflammatory disease [6]. Low-grade inflammation typically refers to conditions in which Objectives: The term low-grade inflammation is usually used to indicate chronic conditions in which the findings of classic, clinical inflammation are lacking, but there is an elevated C-reactive protein (CRP) level of 3 to 10 mg/L. Recently, the systemic immune-inflammation index (SII) was developed based on lymphocyte, neutrophil, and platelet counts, which can project the inflammatory and immune imbalances. The aim of this study was to examine the SII and new parameters derived from hemograms to determine if they have the potential to detect patients with subclinical lowgrade inflammation in an unselected, elderly, outpatient population. Methods: The CRP level was analyzed with a BN II System nepholometer (Siemens Healthineers, Erlangen, Germany). Participants were stratified according to CRP level: Group 1 had a serum CRP result <3.0 mg/L and Group 2 had a serum CRP result 3.0-9.0 mg/L. Blood samples that had been analyzed with an automated hematology analyzer (Mindray BC-5800; Mindray Biomedical Electronics Co., Ltd., Shenzhen, China) were selected for evaluation of the results. The SII (neutrophil x platelet / lymphocyte), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) were calculated. PLR (r=0.773; p<0.001), and the platelet count (r=0.653; p<0.001) was found. However, there was no correlation between the CRP, SII (r=-0.312; p=0.210), and PLR (r=-0.165; p=0.117). Conclusion: A high PLR and SII appears to be associated with subclinical low-grade inflammation. These data do not support hematological screening parameters as a substitute for CRP. These findings are limited to the cohort studied here, and may not be entirely applicable to other ethnic origins. Keywords: C-reactive protein, lymphocyte, neutrophil, platelet Relationship between C-reactive protein, systemic immuneinflammation index, and routine hemogram-related inflammatory markers in low-grade inflammation

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Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases

Cited by 283 publications

References 154 publications

Increased body fat and reduced insulin sensitivity are associated with impaired endothelial function and subendocardial viability in healthy, non‐Hispanic white adolescents

Increased body fat and reduced insulin sensitivity are associated with impaired endothelial function and subendocardial viability in healthy, non‐Hispanic white adolescents

Application of a decision tree to establish factors associated with a nomogram of aortic stiffness

Relationship between CRP, systemic immune-inflammation index and routine hemogram related inflammatory markers in low grade inflammation

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