Inflammatory Markers in Children With Newly Diagnosed Inflammatory Bowel Disease

Day, Andrew S.; Hamilton, Darcy; Leach, Steven T.; Lemberg, Daniel A

doi:10.17554/j.issn.2224-3992.2016.05.647

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Serum inflammatory markers (erythrocyte sedimentation rate (ESR), C‐reactive protein (CRP), platelets, albumin) are quick, easy, cheap and widely accessible. However, these tests lack specificity 23 . Further, these serum markers may not be concordant and may be less useful in the setting of UC than in CD.…”

Section: Initial Steps In Assessment Of Possible Ibdmentioning

confidence: 99%

Identification and diagnosis of Crohn disease and ulcerative colitis in children

Day

Lemberg

2020

J Paediatrics Child Health

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Crohn disease and ulcerative colitis are the two main types of inflammatory bowel disease. High rates of these conditions are seen in Australasian childrenfurthermore, increasing rates have been evident in recent years. Children can present with typical symptoms of abdominal pain, diarrhoea, haematochezia and/or weight loss. Atypical presentations (such as skin lesions or isolated short stature) can also occur: these may be associated with delays in the consideration and diagnosis of IBD. Initial steps in establishing a diagnosis of IBD include delineation of inflammatory markers exclusion of any other likely aetiology. Definitive diagnosis relies upon key endoscopic, histologic and radiological findings. Overall management of IBD encompasses care within a team-based, child and family-focused, multidisciplinary setting.

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Section: Initial Steps In Assessment Of Possible Ibdmentioning

confidence: 99%

Identification and diagnosis of Crohn disease and ulcerative colitis in children

Day

Lemberg

2020

J Paediatrics Child Health

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“…Generally, markers such as calprotectin provide greater specificity and sensitivity for the presence of gut inflammation than standard serum-based markers. In one assessment of routine serum markers at the time of diagnosis, erythrocyte sedimentation rate, C-reactive protein, albumin, and platelet counts were each normal in 19 (13%) and all abnormal in just 52 (36%) of 146 children with CD ( 5 ). Overall, the platelet count was most often abnormal in this group.…”

mentioning

confidence: 99%

Commentary: Impact of Fecal Calprotectin Measurement on Decision-Making in Children with Inflammatory Bowel Disease

Day

Adamji

2017

Front. Pediatr.

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An update on diagnostic and prognostic biomarkers in inflammatory bowel disease

Day

Leach

Lemberg

2017

Expert Review of Molecular Diagnostics

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Diagnosis of the chronic inflammatory bowel diseases relies upon initial recognition of an inflammatory condition, followed by definitive endoscopic, histological and radiological investigations. Various biomarkers are available to assist with initial elucidation of an inflammatory process: these also have important roles after diagnosis in monitoring and ongoing assessment of progress. Areas covered: Various inflammatory markers, serological tests and genetic analyses may be helpful in predicting the course of disease in the coming months. This review provides an update on the current understanding and knowledge about these markers. It also highlights key gaps and identifies aspects that require further study. Expert commentary: Our current approach to the application of non-invasive biomarkers is rudimentary. Further work is required to elucidate the roles of the various markers.

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Inflammatory Markers in Children With Newly Diagnosed Inflammatory Bowel Disease

Abstract: abnormal tests. These patterns should be considered when investigating children with symptoms of possible IBD: one marker should not be considered in isolation.

Cited by 3 publications

References 9 publications

Identification and diagnosis of Crohn disease and ulcerative colitis in children

Identification and diagnosis of Crohn disease and ulcerative colitis in children

Commentary: Impact of Fecal Calprotectin Measurement on Decision-Making in Children with Inflammatory Bowel Disease

An update on diagnostic and prognostic biomarkers in inflammatory bowel disease

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