Inflammatory Markers in Patients after Hematopoietic Stem Cell Transplantation

Sjøqvist, Camilla; Snarski, Emilian

doi:10.1007/s00005-013-0228-z

Cited by 15 publications

(12 citation statements)

References 28 publications

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“…Thymoglobulin consists of a polyclonal mix of antibodies directed toward T lymphocytes and induces complementdependent lysis and Fc receptor-dependent opsonization mediated by monocytes and phagocytes [28]. Thymoglobulin infusion can induce an inflammatory response with high cytokine levels and fever, chills, and a rise in CRP (serum sickness) [29][30][31]. Thymoglobulin is also thought to have immunoregulatory effects [32].…”

Section: Discussionmentioning

confidence: 99%

Profound but Transient Changes in the Inflammatory Milieu of the Blood During Autologous Hematopoietic Stem Cell Transplantation

Wiberg

Olsson‐Strömberg

Herman

et al. 2020

Biology of Blood and Marrow Transplantation

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A B S T R A C TLittle is known about the inflammatory milieu in the blood during autologous hematopoietic stem cell transplantation (AHSCT) and how it is affected by the stem cell mobilization, collection, and reinfusion and conditioning regimen. In this study, we analyzed 92 proteins connected to inflammation at 10 time points during and after AHSCT in 16 patients with multiple sclerosis (MS). Serum from 29 patients with newly diagnosed MS and 15 healthy controls were included for comparative analysis. There were no significant differences in inflammatory serum protein levels between patients with newly diagnosed MS and healthy controls, but 29 out of 73 detectable proteins were significantly altered between at least 2 adjacent sampling time points during AHSCT. The predominant changes occurred after the conditioning regimen had been administered, whereas stem cell mobilization, collection, and reinfusion appeared to have less impact. Two distinct response patterns could be discerned, likely representing loss of basal cytokine production and homeostasis. The analyzed serum proteins gradually returned to baseline levels after treatment, with no remaining differences at 3 months after AHSCT. We conclude that treatment with AHSCT has a major but transient impact on the inflammatory milieu of peripheral blood.

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Section: Discussionmentioning

confidence: 99%

Profound but Transient Changes in the Inflammatory Milieu of the Blood During Autologous Hematopoietic Stem Cell Transplantation

Wiberg

Olsson‐Strömberg

Herman

et al. 2020

Biology of Blood and Marrow Transplantation

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“…The negative microbiological cultures may result from aggressive prophylaxis and antiinfective therapy with antibiotics. Furthermore, a sterile laminar-flow environment, the presence of agranulocytosis, medication for infection and GVHD may all have an impact on test results and mislead physicians (13); thus, the importance of a timely diagnosis of infection cannot be over-emphasized (14).…”

Section: Discussionmentioning

confidence: 99%

Impact of pre-transplant pulmonary infection developed in horizontal laminar flow unit on the outcome of subsequent allogeneic hematopoietic stem cell transplantation

Chang

et al. 2016

J. Thorac. Dis.

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Background: So far, there is very little literature on how pre-transplant pulmonary infection developed in horizontal laminar flow unit (HLFU) affects outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT).Methods: A retrospective analysis was performed on allo-HSCT recipients who were diagnosed with pretransplant pulmonary infection developed in HLFU between January 2012 and December 2012. Various tests were analyzed to evaluate the overall survival (OS) and pulmonary infection rate after allo-HSCT.Results: Among 317 patients who received allo-HSCT from related donors, 7 cases of human leukocyte antigen (HLA)-haploidentical transplantation reported a fever, cough, and other symptoms before transplantation. Chest radiography findings showed pulmonary infection, and the C-reactive protein (CRP) level was higher than normal, which confirmed pulmonary infection (incidence rate 2.21%). The Breslow test suggested that the early survival rate was lower in the group with pre-transplant pulmonary infection than in the group without pre-transplant pulmonary infection (OS: 28.4 vs. 42.4 months; P=0.023); the early survival rate was lower in patients with a pulmonary infection accompanied by bilateral pleural effusion than in patients without pleural effusion (OS: 1.5 vs. 36.3 months; P=0.010). In the first month after transplantation, the difference in the CD4CD45RO+CD45RA-and CD4CD45RO-CD45RA+ between the groups with and without pre-transplant pulmonary infection was statistically significant (P<0.05). Patients with pre-transplant pulmonary infection who survived >3 years had a higher rate of pulmonary infection in the first 2 months after allo-HSCT than those without pre-transplant pulmonary infection [100% (5/5 patients) vs. 38.1%(118/310); χ 2 =5.542, P=0.019].Conclusions: Development of pre-transplant pulmonary infection in the HLFU in patients with hematological malignancies who receive HLA-haploidentical HSCT is associated with an increased risk of recurrent pulmonary infection in the early period after transplantation; however, there is no impact on patients' long-term survival rate.

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“…21 Increased serum level of some proinflammatory cytokines was also observed during such complications after transplantation. 22 In Iran, the incidence of transplantable diseases is relatively high, reaching 1,400 patients per year. 23 It was reported that a total of 3,170 HSCTs were carried out since the establishment of transplantation centers in Iran within the past 20 years, and the rates are increasing annually.…”

Section: Introductionmentioning

confidence: 99%

<p>Effect of pretransplant depression on neutrophil recovery following hematopoietic stem cell transplantation</p>

Tavakoli-Ardakani¹,

Beyraghi²,

Mirjalili³

et al. 2019

TRRM

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Purpose: Pre-transplantation depression is known to exert negative effects on clinical outcomes after hematopoietic stem cell transplantation (HSCT). Accumulating evidence shows a bidirectional association between inflammation and depression. Systemic inflammation can affect clinical outcomes after transplantation, such as time to engraftment. This study evaluated the effect of pre-transplantation depression and serum level of proinflammatory and anti-inflammatory cytokines on clinical outcomes such as neutrophil recovery time and mortality in patients undergoing HSCT. Patients and methods: In this cross-sectional study, we recruited 73 patients who were autologous or allogeneic HSCT candidates. Hospital Anxiety and Depression Scale questionnaire was used to assess depression in the first 2 days after their hospital admission. Serum levels of IL-10, IL-6, and hs-CRP were measured at the same time. Neutrophil engraftment time, length of hospitalization, rate of mortality, relapses, readmissions, and occurrence of major complications following HSCT in a 1-year follow-up period were recorded as comparative outcomes. Results: Thirty-five patients with depression and 38 patients without depression participated in the study. Among the related outcomes, time of engraftment (P=0.020) and mortality rate (P=0.059) were statistically different between the two groups. Depressed patients had longer neutrophil engraftment time and higher mortality rate 1 year following transplantation (14.14±3.95 days and 31.43%) in comparison to non-depressed patients (12.21±2.81 days and 13.16%). Depressed patients showed significantly higher serum levels of IL-6 and IL-6-to-IL-10 ratio compared to non-depressed participants (P<0.001 and P=0.004). Conclusion: According to the results, pre-transplant depression can negatively impact neutrophil recovery time and mortality rate following HSCT. Higher levels of inflammatory factors in depressed patients might be one of the mechanisms that negatively affect clinical outcomes after HSCT.

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Inflammatory Markers in Patients after Hematopoietic Stem Cell Transplantation

Cited by 15 publications

References 28 publications

Profound but Transient Changes in the Inflammatory Milieu of the Blood During Autologous Hematopoietic Stem Cell Transplantation

Profound but Transient Changes in the Inflammatory Milieu of the Blood During Autologous Hematopoietic Stem Cell Transplantation

Impact of pre-transplant pulmonary infection developed in horizontal laminar flow unit on the outcome of subsequent allogeneic hematopoietic stem cell transplantation

<p>Effect of pretransplant depression on neutrophil recovery following hematopoietic stem cell transplantation</p>

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