Inflammatory Markers of Geriatric Depression Response to Tai Chi or Health Education Adjunct Interventions

Siddarth, Prabha; Abikenari, Matthew A.; Grzenda, Adrienne; Cappelletti, Monica; Oughli, Hanadi Ajam; Liu, Claire; Millillo, Michaela; Lavretsky, Helen

doi:10.1016/j.jagp.2022.08.004

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…Whole blood was centrifuged at 2000 rpm for 10 min and plasma immediately stored at −80 °C. Human 38-plex magnetic cytokine/chemokine kits (EMD Millipore, HCYTMAG-60K-PX38, Burlington, MA) were used per manufacturer’s instructions and as previously described [ 31 , 32 ]. The panel includes IL-1RA, IL-10, IL-1α, IL-1β, IL-6, IFN-α2, TNF/TNF-α, TNF-β/LT-α, sCD40L, IL-12p40, IFN-γ, IL-12/IL-12p70, IL-4, IL-5, IL-13, IL-9, IL-17A, GRO/CXCL1, IL-8/CXCL8, eotaxin-1/CCL11, MDC/CCL22, fractalkine/CX3CL1, IP-10/CXCL10, MCP-1/CCL2, MCP-3/CCL7, MIP-1α/CCL3, MIP-1β/CCL4, IL-2, IL-7, IL-15, GM-CSF, Flt-3L/CD135, G-CSF, IL-3, EGF, FGF-2, TGF-α, and VEGF.…”

Section: Methods Participantsmentioning

confidence: 99%

Cognitive and immunological effects of yoga compared to memory training in older women at risk for alzheimer’s disease

Grzenda,

Siddarth,

Milillo

et al. 2024

Transl Psychiatry

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Subjective cognitive decline (SCD) and mild cognitive impairment (MCI) accompanied by cerebrovascular risk factors (CVRFs) are known to increase the risk of developing dementia. Mind-body practices such as yoga and meditation, have been recognized as safe techniques with beneficial effects on cognitive functions in older adults at risk for cognitive decline. We conducted a randomized, controlled trial to assess the efficacy of Kundalini yoga training (KY) compared to memory enhancement training (MET) on mood and cognitive functioning in a group of older women with CVRFs and SCD (clinicaltrials.gov = NCT03503669). The KY intervention consisted of weekly, 60-min in-person classes with a certified instructor for 12 weeks, with a 12-min guided recording for daily homework practice at home. MET involved 12 weekly in-person group classes with 12-min daily homework exercises. Objective and subjective memory performance were the primary outcomes. Peripheral whole blood samples were collected at baseline, 12-weeks, and 24-weeks follow-up for RNA sequencing and cytokine/chemokine assays. A total of 79 patients (KY = 40; MET = 39) were randomized, and 63 completed the 24-week follow-up (KY = 65% completion rate; MET = 95%; χ2(1) = 10.9, p < 0.001). At 24-weeks follow-up, KY yielded a significant, large effect size improvement in subjective cognitive impairment measures compared to MET. KYOn a transcriptional level, at 12- and 24-week follow-up, KY uniquely altered aging-associated signatures, including interferon gamma and other psycho-neuro-immune pathways. Levels of chemokine eotaxin-1, an aging marker, increased over time in MET but not KY participants. These results suggest clinical and biological benefits to KY for SCD, linking changes in cognition to the anti-inflammatory effects of yoga.

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Section: Methods Participantsmentioning

confidence: 99%

Cognitive and immunological effects of yoga compared to memory training in older women at risk for alzheimer’s disease

Grzenda,

Siddarth,

Milillo

et al. 2024

Transl Psychiatry

Self Cite

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The effect of Tai Chi on elderly depression: a systematic review and meta-analysis of randomized controlled trials

Zhu,

Wang,

Yin

et al. 2024

Front. Psychol.

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ObjectiveThis systematic review and meta-analysis assess the impact of Tai Chi on emotional well-being and quality of life in elderly individuals with depression.MethodsSearching six databases until October 20, 2024, including Embase, PubMed, Cochrane Library, Web of Science, SinoMed, and CNKI, for randomized controlled trials (RCTs). Participants were aged ≥60 and diagnosed with depression. Tai Chi served as the main intervention in the treatment group, with the control group receiving no exercise, or only health education. The primary outcomes focused on the improvement of depressive symptoms and quality of life. Data synthesis and meta-analysis were performed using Stata 15.1 software. The protocol of this study was registered on PROSPERO (ID: CRD42023479305).ResultsTai Chi, as the main intervention, significantly improved depressive symptoms as measured by the Geriatric Depression Scale (WMD = −5.99, 95% CI: −10.80 to −1.19, p = 0.015) compared to no exercise or health education. Subgroup analysis favored a six-month duration of Tai Chi, showing even greater benefits (WMD = −9.79, 95% CI: −13.90 to −5.69, p < 0.001). However, Tai Chi did not demonstrate a significant advantage in improving participants’ scores on the Hamilton Depression Scale (WMD = −1.04, 95% CI: −3.84 to 1.76, p = 0.468).ConclusionOur results indicate that Tai Chi can significantly improve depressive symptoms and quality of life in elderly individuals with depression. As a daily exercise and mind–body therapy to alleviate the mood of the elderly, it is necessary to conduct more large-sample RCTs. Further research on the details of Tai Chi, such as movements, frequency, duration, and exercise periods, is essential for a dose–response relationship, contributing to the standardized promotion of Tai Chi.

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Inflammatory Markers of Geriatric Depression Response to Tai Chi or Health Education Adjunct Interventions

Cited by 2 publications

References 41 publications

Cognitive and immunological effects of yoga compared to memory training in older women at risk for alzheimer’s disease

Cognitive and immunological effects of yoga compared to memory training in older women at risk for alzheimer’s disease

The effect of Tai Chi on elderly depression: a systematic review and meta-analysis of randomized controlled trials

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