Inflammatory Mechanism of Brucella Infection in Placental Trophoblast Cells

Xiao, Yinlong; Li, Mengjuan; Guo, Xi; Zeng, Han; Shuai, Xuehong; Guo, Jianhua; Huang, Qingzhou; Chu, Yuefeng; Zhou, Baoyuan; Wen, Julie; Li, Jun; Hu, Jiao

doi:10.3390/ijms232113417

Cited by 8 publications

(7 citation statements)

References 115 publications

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“…In the third semester, the group of animals with a history of abortion had a higher seropositivity ( Tarusikirwa et al ., 2023 ). The presence of erythritol, a growth stimulant for B. abortus , increases the susceptibility of cows to Brucella infection, especially in early pregnancy, and the condition can result in late-term abortion ( Xiao et al ., 2022 ). Following the initial abortion, the animal is capable of giving birth without any issues.…”

Section: Clinical Symptoms In Humansmentioning

confidence: 99%

“…The uterus, epididymis, breast tissue, and fetus of animals all have high quantities of erythritol ( Carvalho et al ., 2023 ). Furthermore, progesterone produced by the placenta promotes Brucella growth in vitro ( Xiao et al ., 2022 ). High quantities of germs are found in the secretions of these tissues; these concentrations are highest in the vagina soon following an abortion or childbirth ( Cosford, 2018 ).…”

Section: Clinical Symptoms In Humansmentioning

confidence: 99%

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Brucellosis: Unveiling the complexities of a pervasive zoonotic disease and its global impacts

Khairullah,

Kurniawan,

Puspitasari

et al. 2024

Open Vet J

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One zoonotic infectious animal disease is brucellosis. The bacteria that cause brucellosis belong to the genus Brucella. Numerous animal and human species are affected by Brucellosis, with an estimated 500,000 human cases recorded annually worldwide. The occurrence of new areas of infection and the resurgence of infection in already infected areas indicate how dynamically Brucellosis is distributed throughout different geographic regions. Bacteria originate from the blood and are found in the reticuloendothelial system, the liver, the spleen, and numerous other locations, including the joints, kidneys, heart, and genital tract. Diagnosis of this disease can be done by Bacterial Isolation, Molecular tests, Modified acid-fast Stain, Rose Bengal Test (RBT), Milk Ring Test (MRT), Complement Fixation Test (CFT), Enzyme-Linked Immunosorbent Assay (ELISA), and Serum Agglutination Test (SAT). The primary sign of a B. abortus infection is infertility, which can result in abortion and the birth of a frail fetus that may go on to infect other animals. In humans, the main symptoms are acute febrile illness, with or without localization signs, and chronic infection. Female cattle have a greater risk of contracting Brucella disease. Human populations at high risk of contracting brucellosis include those who care for cattle, veterinarians, slaughterhouse employees, and butchers. Antibiotic treatment of brucellosis is often unsuccessful due to the intracellular survival of Brucella and its adaptability in macrophages. A 'One Health' strategy is necessary to control illnesses like brucellosis.

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Section: Clinical Symptoms In Humansmentioning

confidence: 99%

Section: Clinical Symptoms In Humansmentioning

confidence: 99%

Brucellosis: Unveiling the complexities of a pervasive zoonotic disease and its global impacts

Khairullah,

Kurniawan,

Puspitasari

et al. 2024

Open Vet J

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“…In the initial stage of infection, macrophages, trophoblastic cell (TE), and other phagocytic cells are the main targets of Brucella infection ( Xiao et al., 2022 ). For Brucella , they are not only the sites for both survival and replication but also a vehicle for transmission to other organ systems.…”

Section: Chronic Intracellular Infection With Brucella ...mentioning

confidence: 99%

The mechanism of chronic intracellular infection with Brucella spp.

Guo

Zeng

et al. 2023

Front. Cell. Infect. Microbiol.

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Globally, brucellosis is a widespread zoonotic disease. It is prevalent in more than 170 countries and regions. It mostly damages an animal’s reproductive system and causes extreme economic losses to the animal husbandry industry. Once inside cells, Brucella resides in a vacuole, designated the BCV, which interacts with components of the endocytic and secretory pathways to ensure bacterial survival. Numerous studies conducted recently have revealed that Brucella’s ability to cause a chronic infection depends on how it interacts with the host. This paper describes the immune system, apoptosis, and metabolic control of host cells as part of the mechanism of Brucella survival in host cells. Brucella contributes to both the body’s non-specific and specific immunity during chronic infection, and it can aid in its survival by causing the body’s immune system to become suppressed. In addition, Brucella regulates apoptosis to avoid being detected by the host immune system. The BvrR/BvrS, VjbR, BlxR, and BPE123 proteins enable Brucella to fine-tune its metabolism while also ensuring its survival and replication and improving its ability to adapt to the intracellular environment.

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“…Given the known relationship between placentitis and adverse pregnancy outcomes in several gestational infections [6], a role for placental inflammation in Brucella-induced abortion and preterm birth has been suggested [7][8][9]. While the inflammatory response of trophoblasts to Brucella has been recently reviewed [10], here we review epidemiological, clinical, and pathological aspects of Brucella-induced pregnancy complications and analyze the ability of the pathogen to infect and replicate in different cell types of the maternal-fetal unit and induce inflammatory responses that may lead to such complications.…”

Section: Introductionmentioning

confidence: 99%

Immune Responses Potentially Involved in the Gestational Complications of Brucella Infection

Zavattieri,

Muñoz González,

Ferrero

et al. 2023

Pathogens

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Infection by Brucella species in pregnant animals and humans is associated with an increased risk of abortion, preterm birth, and transmission of the infection to the offspring. The pathogen has a marked tropism for the placenta and the pregnant uterus and has the ability to invade and replicate within cells of the maternal–fetal unit, including trophoblasts and decidual cells. Placentitis is a common finding in infected pregnant animals. Several proinflammatory factors have been found to be increased in both the placenta of Brucella-infected animals and in trophoblasts or decidual cells infected in vitro. As normal pregnancies require an anti-inflammatory placental environment during most of the gestational period, Brucella-induced placentitis is thought to be associated with the obstetric complications of brucellosis. A few studies suggest that the blockade of proinflammatory factors may prevent abortion in these cases.

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Inflammatory Mechanism of Brucella Infection in Placental Trophoblast Cells

Cited by 8 publications

References 115 publications

Brucellosis: Unveiling the complexities of a pervasive zoonotic disease and its global impacts

Brucellosis: Unveiling the complexities of a pervasive zoonotic disease and its global impacts

The mechanism of chronic intracellular infection with Brucella spp.

Immune Responses Potentially Involved in the Gestational Complications of Brucella Infection

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