Inflammatory mediators in nasal lavage, induced sputum and serum of employees with rheumatic and respiratory disorders

Roponen, Marjut; J, Kiviranta; Seuri, Markku; Tukiainen, H; Myllykangas-Luosujärvi, R; Hirvonen, M.-R.

doi:10.1183/09031936.01.00097301

Cited by 22 publications

(17 citation statements)

References 26 publications

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“…After exclusion of the asthmatic subject, there was no difference in FEV1 decrease between the challenges. This is in line with a previous study where no significant differences in lung functions were found between occupants with respiratory or rheumatic disorders and their controls, all working in the same moisture-damaged building [5]. Conversely, in this study, the baseline FVC and FEV1 were significantly lower among the mould-exposed subjects when compared with their controls.…”

Section: Discussionsupporting

confidence: 93%

“…This finding is also supported by previous studies pointing out that subjects exposed to indoor air microbes more frequently report airway symptoms than their control counterparts [5,24].…”

Section: Discussionsupporting

confidence: 88%

“…Increased fractional nasal nitric oxide (FnNO) levels have been reported in patients with seasonal rhinitis [3]. In addition, an elevated level of nitric oxide (NO) assessed as nitrite in nasal lavage fluid (NAL) has been detected after occupational exposure to microbes from moisture-damaged buildings [4,5]. However, no significant differences have been detected in the levels of FeNO between subjects exposed to microbes from a moisture-damaged building and control subjects [6].…”

mentioning

confidence: 99%

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The effects ofAspergillus fumigatuschallenge on exhaled and nasal NO levels

Jt²,

Hirvonen³

et al. 2005

Eur Respir J

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Several studies have previously shown that exposure to indoor air microbes from moisture-damaged buildings can cause adverse health effects. Aspergillus fumigatus is one of the best-documented moulds causing health problems to those exposed.In this study, inhalation of a commercial A. fumigatus solution was assessed, to establish if it would have effects on fractional exhaled (FeNO) and nasal (FnNO) nitric oxide levels and on lung function. The results were compared with placebo challenge.

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Section: Discussionsupporting

confidence: 93%

“…This finding is also supported by previous studies pointing out that subjects exposed to indoor air microbes more frequently report airway symptoms than their control counterparts [5,24].…”

Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 99%

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The effects ofAspergillus fumigatuschallenge on exhaled and nasal NO levels

Jt²,

Hirvonen³

et al. 2005

Eur Respir J

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“…Exhaled NO levels were significantly elevated in children living in homes with average FA levels ≥ 50 ppb (Franklin et al, 2000). Moreover, employees with respiratory symptoms had markedly higher exhaled NO values (Roponen et al, 2001). These results suggested that VOCs could increase the activity of NOS.…”

Section: Introductionmentioning

confidence: 54%

Effect of exposure to volatile organic compounds (VOCs) on airway inflammatory response in mice

Wang

Liu

et al. 2012

J. Toxicol. Sci.

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-Volatile organic compounds (VOCs) are the main substances causing multiple chemical sensitivity reactions in human. The effects of single VOCs exposure on airway inflammatory responses in mice lung have been reported. Previous studies have demonstrated the role of reactive oxygen species (ROS) in lung inflammation induced by single VOCs inhalation. However, effects of VOCs exposure on NO signaling and neurological signaling pathways in airway remain less clear. We exposed male Kunming mice to filtered air (0) and four types of VOCs mixture (formaldehyde, benzene, toluene, and xylene) treated air. Group 1 is 1.0, 1.1, 2.0 and 2.0 mg/m 3 , group 2 is 3.0, 3.3, 6.0 and 6.0 mg/m 3 , group 3 is 5.0, 5.5, 10.0 and 10.0 mg/m 3 , group 4 is 10.0, 11.0, 20.0 and 20.0 mg/m 3 , which respectively corresponded to 10, 30, 50 and 100 times of indoor air quality standard in China 2 hr per day, 5 days per week, for 2 weeks in the whole body exposure chamber. One day following VOCs exposure, we collected lung, bronchoalveolar lavage fluid (BALF) from each mouse and examined oxidative stress markers, cellular infiltration and production of cytokines, neurotrophin and substance P. We found that VOCs exposure influenced significantly NOS activity, GSH, or IL-6 concentration. The number of total cells, macrophages and eosinophils increased significantly in group 4. In addition, the production of interferon-gamma (IFN-γ) and substance P were significantly decreased. In contrast, neurotrophin-3 production in BALF was significantly increased in group 3 and 4. Our findings suggest that NO signaling pathways may induce airway inflammatory in short term VOCs exposure mice and the airway inflammatory response may be modulated by neurological signaling.

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“…For HDMs, sensitization limit of 100 mites/g has been suggested (Platts-Mills et al 1989), but no corresponding value for SMs has been published. A high prevalence of positive skin prick test (SPT) results for SM allergens has been reported in symptomatic employees working in a moisture-damaged building (Roponen et al 2001). In moisture-damaged buildings, the symptoms are often considered as irritation or inflammation symptoms because IgE-mediated mould allergy is only seldom found.…”

Section: Introductionmentioning

confidence: 98%