Inflammatory Mediators Leading to Edema Formation through Plasma Membrane Receptors

Teixeira, Guilherme Pegas; Faria, Robson Xavier

doi:10.5772/intechopen.99230

Cited by 7 publications

(6 citation statements)

References 137 publications

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“…Although cerebral edema and disease severity may correlate with high CSF protein, without any cellular reaction CSF pressure and protein may elevate more than 100 mg/dL 12 . Moreover, Increase in vascular permeability due to release of inflammatory cytokines resulted in interstitial brain edema 13–15 . The characteristic MRI finding of vasogenic edema involving parieto‐occipital region of both cerebral hemispheres are essential for diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“… 12 Moreover, Increase in vascular permeability due to release of inflammatory cytokines resulted in interstitial brain edema. 13 , 14 , 15 The characteristic MRI finding of vasogenic edema involving parieto‐occipital region of both cerebral hemispheres are essential for diagnosis. Frequently the subcortical white matter is involved.…”

Section: Discussionmentioning

confidence: 99%

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Posterior reversible encephalopathy syndrome associated with dengue fever induced intrauterine death: A case report

Biswas,

Ibu,

Biswas

et al. 2024

Clinical Case Reports

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Key Clinical MessageIn recent years dengue fever has become a major health concern specifically due to its diverse presentation and adverse outcome. Progression from mild febrile illness to a severe systemic illness may occur in dengue fever including neurological disorder. Here, we report an unusual and rare case of a 20‐year‐old mother who developed posterior reversible encephalopathy syndrome (PRES) following dengue fever induced intrauterine death and septic shock.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Posterior reversible encephalopathy syndrome associated with dengue fever induced intrauterine death: A case report

Biswas,

Ibu,

Biswas

et al. 2024

Clinical Case Reports

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“…Although the exact mechanism underlying mucosal edema, a known PIT complication, remains unknown, we speculate that its occurrence is based on the following rationale: PIT induces tumor cell necrosis, releasing damage-associated molecular patterns (DAMPs), which stimulate cytokine production and trigger an inflammatory response. The subsequent increase in vascular permeability is believed to contribute to edema [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Photoimmunotherapy for Nasopharyngeal Carcinoma Requiring Emergency Tracheostomy

Kushihashi,

Masubuchi,

Okamoto

et al. 2024

Case Rep Oncol

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Introduction: Photoimmunotherapy (PIT) is a treatment wherein intravenous cetuximab sarotalocan sodium is administered followed by laser light irradiation. This treatment exhibits a specific antitumor effect if in tumors expressing the epidermal growth factor receptor, regardless of the carcinoma [Mitsunaga et al.: Nat Med. 2011;17(12):1685–91, Sato et al.: ACS Cent Sci. 2018;4(11):1559–69, Nakajima et al.: Cancer Sci. 2018;109(9):2889–96]. The current indications are unresectable, locally advanced, or locally recurrent head and neck cancer. If standard treatments, such as radiotherapy and chemotherapy, are available, they are given priority. However, a significant concern in PIT is the occurrence of airway emergencies related to pharyngeal edema. Prophylactic tracheostomy is often performed in cases of PIT involving the root of the tongue, hypopharynx, or larynx. Case Presentation: In this study, we administered transoral PIT to a patient diagnosed with radiation-induced nasopharyngeal carcinoma (squamous cell carcinoma (SCC) cT1N0M0 stage I). Although previous case reports and our own experiences did not report airway emergencies following PIT for nasopharyngeal carcinoma, a unique case occurred in our study [Omura et al.: Auris Nasus Larynx. 2023;50(4):641–5, Kushihashi et al.: Int J Otolaryngol Head Neck Surg. 2022;11(5, Sep):258–65]. The patient experienced poor oxygenation and a decreased level of consciousness early in the morning following the laser irradiation. Nasal endoscopy revealed airway narrowing due to upper airway edema, and intubation was challenging. Consequently, we performed emergency bedside tracheostomy and the patient’s condition improved. Conclusion: Therefore, it is crucial to note that airway emergencies can be life-threatening and should be diligently monitored as a potential complication of PIT.

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“…In addition to its potential analgesic properties, it is important to note that the mango extracts may also have anti-inflammatory effects. Inflammation can lead to the development of edema, which is characterized by an abnormal accumulation of fluid in the interstitial spaces of injured tissues [41]. This process is mediated by the release of inflammatory mediators, such as histamine and prostaglandins, which cause vasodilation and increased vascular permeability [42,43].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Biological Activities of Mahajanaka Mango Pulp Extract in Murine Models

Paradee,

Janthip,

Taesothikul

et al. 2023

Applied Sciences

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Mahajanaka mango, a hybrid cultivar of Mangifera indica Linn., is a highly nutritional fruit that is popularly consumed in Thailand. It has been used in traditional medicine due to its abundance of phytonutrients. The present study aimed to investigate the chemical compositions and antioxidant activity of Mahajanaka mango pulp extract (MPE) in vitro. Additionally, we examined its biological activities, including the analgesic, anti-inflammatory, gastroprotective, and hepatoprotective effects of MPE, in murine models. MPE exhibited high levels of phenolic compounds, mangiferin, β-carotene, and vitamin C, and it potentially showed antioxidant properties in an ABTS scavenging assay. The animal results have revealed that oral administration of MPE (1000 mg/kg body weight (BW)) significantly decreased acetic acid-induced writhing responses in mice. Interestingly, local applications of MPE at 1 mg/ear ameliorated ethyl phenylpropiolate (EPP)-induced ear edema, while gavage of MPE at 1000 mg/kg BW significantly decreased carrageenan-induced hind paw edema in rats. MPE can also protect against gastric ulcers induced by stress, hydrochloric acid/ethanol, and indomethacin in rats. Indeed, MPE (250 mg/kg BW) markedly lowered the level of serum alanine aminotransferase activity and hepatic lipid accumulation in rats with CCl4- and paracetamol-induced hepatotoxicity. Taken together, the findings suggested that MPE exerts potent antioxidant, analgesic, anti-inflammatory, gastroprotective, and hepatoprotective effects.

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Inflammatory Mediators Leading to Edema Formation through Plasma Membrane Receptors

Cited by 7 publications

References 137 publications

Posterior reversible encephalopathy syndrome associated with dengue fever induced intrauterine death: A case report

Posterior reversible encephalopathy syndrome associated with dengue fever induced intrauterine death: A case report

A Case of Photoimmunotherapy for Nasopharyngeal Carcinoma Requiring Emergency Tracheostomy

Antioxidant and Biological Activities of Mahajanaka Mango Pulp Extract in Murine Models

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