Inflammatory modulation of calcium-activated potassium channels in canine colonic circular smooth muscle cells

Abnormal Motility in Patients With Ulcerative Colitis

“…The findings that in patients with UC shortenings in response to NKA and thapsigargin were reduced suggest that depletion of intracellular Ca 2+ stores may contribute to the reduction of circular muscle contractility. These data are consistent with some previous reports [55][56][57] and do not support the view that the observed changes may be caused by a damaged contractile mechanism. 24 Our data demonstrate that IL-1␤ has a significant effect on muscle strip force development and cell shortening and are consistent with previously reported data in colonic muscle strips in the rat.…”

Molecular diversity and function of K+ channels in airway and alveolar epithelial cells

“…The impact of inflammation on K ϩ channels has been studied in several other tissues. It has been reported, for example, that inflammation stimulates K ATP channels (30) and decreases BK Ca open probability (47) in smooth muscle cells. The proinflammatory cytokine tumor necrosis factor (TNF) also exerts a complex action on K ϩ channels by upregulating some of them (21, 85, 93) and downregulating others (66,85).…”

Genetic variation in DLG5 is associated with inflammatory bowel disease

“…TSC0376484 is located near two genes of possible (patho)physiological relevance to chronic intestinal inflammation: KCNMA1, encoding a potassium-gated calcium channel 6 , and DLG5, a member of the membrane-associated guanylate kinase gene family, which is important in the maintenance of epithelial cell integrity 7 . To genetically narrow the association signal to one single candidate, we used LD mapping and genotyped selected publicly available SNPs from each gene in the 457 trios with IBD.…”