Inflammatory Myofibroblastic Tumor 12 Years After Treatment for Synovial Sarcoma: A Case Report

Abstract

Inflammatory myofibroblastic tumors (IMTs) are mesenchymal neoplasms most seen in the abdominopelvic region, lung, and retroperitoneum; and less commonly seen in virtually any other site. We report a case of two lower limb masses consistent with diagnosis of IMTs. This is a 39-year-old woman with a history of right lower extremity popliteal fossa synovial sarcoma diagnosed 12 years prior and treated with chemotherapy, surgery, and radiation. She presented with two new -one anterior and one posterior -right thigh masses. Biopsies of the lesions demonstrated low-grade inflammatory spindle cell lesions at both sites. Wide resection was performed for both masses and further characterization of the surgical specimens was most consistent with IMT. At follow-up, the patient is well with no signs of recurrence 19 and 7 months postoperative to the resection of the anterior and posterior thigh masses, respectively. This case represents the first reported IMTs occurring as late as 12 years after primary cancer treatment, and the first occurring after synovial sarcoma.

Inflammatory Myofibroblastic Tumor of the Hilar Bile Duct: A Case Report and Literature Review

“…He et al reported a case of a 68year-old woman with intrapancreatic IMT and invasion of the spleen and diaphragm (26); the woman was found to be ALKnegative by next-generation sequencing but showed dual amplification of CDK4 and MDM2. Shah et al reported a case of ALK-negative IMT after 12 years of treatment for synovial sarcoma in both lower extremities (27), and the patient had a good prognosis without signs of recurrence at postoperative follow-up. Antonescu et al found a correlation between the genotype and specific clinical-pathological characteristics of IMT (28).…”

An extremely rare case of malignant jejunal mesenteric inflammatory myofibroblastic tumor in a 61-year-old male patient: A case report and literature review

“…The sclerosing pattern represents sclerosed desmoid-like areas that interfere with calcification. Undesirable prognosis results from high mitotic tendency, hypercellularity, and proliferation capacity, all of which are the characteristics of the proliferating pattern ( 64 ). Moreover, devastating prognostic characteristics include the presence of bizarrely shaped and round cells instead of spindle-shaped cells, nuclear pleomorphism, and infiltrating borders ( 12 , 62 ).…”