Inflammatory myofibroblastic tumor

Palaskar, Sangeeta; Supriya, K.; Maralingannavar, Mahesh; Bartake, Anirudha

doi:10.4103/0976-237x.91787

Cited by 87 publications

(100 citation statements)

References 9 publications

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“…The true pathogenesis of IMT remains unknown, however infectious, immune‐mediated and traumatic processes have been suggested as possible aetiological factors, alongside the primary neoplastic theory (Palaskar et al . ). Malignant transformation secondary to an inflammatory stimulus has been described in the canine spleen (Spangler & Kass ).…”

Section: Discussionmentioning

confidence: 97%

Inflammatory myofibroblastic tumour in the nasal cavity of a dog

Swinbourne

Kulendra

Smith

et al. 2013

J of Small Animal Practice

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A 4·5-year-old, female neutered Leonberger was presented with a 2-month history of sneezing, nasal discharge and epistaxis. A presumptive diagnosis of nasal aspergillosis was made based on a suspected (fungal) granuloma on rhinoscopic examination and fungal hyphae on cytological examination. A poor response to targeted therapy was observed and computed tomography 16 months after initial presentation revealed a progressive, locally invasive mass lesion. Histopathological and immunohistochemical analysis of deep surgical biopsies revealed a spindle cell population and a plasma cell rich inflammatory infiltrate, with diffuse expression of vimentin, supporting a diagnosis of inflammatory myofibroblastic tumour. Complete resolution of the nasal discharge and reduced sneezing frequency was reported 9 months post-surgical debridement via rhinotomy. To the authors' knowledge, this is the first report of IMT in the nasal cavity of a dog. IMT should be considered when presented with a nasal mass lesion, particularly if histopathological features and clinical course are inconsistent.

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Section: Discussionmentioning

confidence: 97%

Inflammatory myofibroblastic tumour in the nasal cavity of a dog

Swinbourne

Kulendra

Smith

et al. 2013

J of Small Animal Practice

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“…[7] The present case revealed painless swelling for 5 months. In the head and neck region, it has been reported in parapharyngeal spaces, maxillary sinus, epiglottis and oral cavity.…”

Section: Discussionmentioning

confidence: 72%

Inflammatory myofibroblastic tumor of mandible: A rare case report and review of literature

Korlepara

Guttikonda

Madala

et al. 2017

J Oral Maxillofac Pathol

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Inflammatory pseudotumor is a term given to different neoplastic and nonneoplastic entities that have a common histological appearance, which comprises spindle cell proliferation with a prominent chronic inflammatory cell infiltrate. Inflammatory myofibroblastic tumor (IMT) is an uncommon lesion with distinctive clinical, pathological and molecular features and is considered to be pseudotumor for the past two decades due to its appearance. IMT is an intermediate soft tissue tumor which was first observed in lungs. It was named as IMT because it mimics a malignant neoplasm clinically, radiologically and histopathologically. The most common sites are lungs, liver and gastrointestinal tract. IMT in head and neck region is exceptionally rare and the sites reported include gingiva, tongue, hard palate, mandible, buccal mucosa and submandibular salivary gland. Till now, 8 cases of intramandibular IMT were reported. Here, we report an additional case of intramandibular IMT in a 20-year-old male patient.

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“…Burke and colleagues [7] have postulated that IMTs arising within the heart might be biologically distinct from those from other body sites. ALK-1 alteration in IMTs can be detected by FISH and IHC, with a high rate of concordance between the 2 detection methods [49,58], However, FISH test is generally considered as a more sensitive and specific detection method for ALK-1, and there are cases without ALK-1 protein expression on IHC showing ALK-1 alteration on FISH [49][50][51][52][53][54][55][56][57][58][59], To our knowledge, this is the 1st case of cardiac IMTs with FISH analysis performed, and no ALK-1 rearrangement was detected in our case. Additional studies using IHC and FISH for ALK-1 are required to clarify if such discrepancy between cardiac and extracardiac IMTs is an aberration or truly indicates a different underlying genotype.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumor of the Aortic Valves Causing Sudden Cardiac Death: A Case Report and Review of the Literature

Fraser

Renaud

et al. 2014

Pediatr Dev Pathol

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Cardiac inflammatory myofibroblastic tumor (IMT) is a rare entity affecting predominantly infants, children, and young adults. Although most tumors have a benign clinical course after complete surgical resection, some have significant clinical effects. We report the case of a 9-year-old girl who had sudden cardiac death as a result of occlusion of the left circumflex coronary artery. A review of 57 cases of cardiac IMTs reported in the literature in terms of epidemiology, clinical presentation, histologic and immunohistologic features, and outcome is presented. Recognition of this rare abnormality is important in order to initiate prompt surgical intervention.

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Inflammatory myofibroblastic tumor

Cited by 87 publications

References 9 publications

Inflammatory myofibroblastic tumour in the nasal cavity of a dog

Inflammatory myofibroblastic tumour in the nasal cavity of a dog

Inflammatory myofibroblastic tumor of mandible: A rare case report and review of literature

Inflammatory Myofibroblastic Tumor of the Aortic Valves Causing Sudden Cardiac Death: A Case Report and Review of the Literature

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