Inflammatory myofibroblastic tumor (Inflammatory pseudotumor): DNA flow cytometric analysis of nine pediatric cases

Abstract

The present data indicate that flow cytometry identifies aneuploidy (hyperdiploidy) in approximately half of the cases of inflammatory myofibroblastic tumors. This feature appears to reflect a more aggressive biologic behavior. In addition to the reported cytogenetic abnormalities, our data suggest that inflammatory myofibroblastic tumor, generally considered a benign reactive inflammatory process, may evolve as a distinct, potentially malignant, lesion. Therefore, flow cytometric DNA analysis is a suitable tool to provide the clinician with both diagnostic and prognostic information and to individuate the most feasible therapeutic approach.

Jejunal inflammatory myofibroblastic tumor: a rare entity

“…14 Birelli and coworker in their study found that around 50% of extrapulmonary IMFT in pediatric age group are aneuploid. 18 Meis and Enzinger in their study of 38 cases found to have 3 patients with distant metastasis and 8 had local invasion. 19 Reports are there in literature supporting the neoplastic nature of the tumor.…”

Fever of Unknown Origin as a Presentation of Gastric Inflammatory Myofibroblastic Tumor in a Two-Year-Old Boy

“…Inflammatory myofibroblastic tumor is a rare benign solid tumor with an obscure etiology (4,5). Despite an apparently benign morphological nature, some cases of IMT have been reported to have a malignant clinical course, such as a locally aggressive growth and a tendency to recur after a complete resection (5).…”

“…Despite an apparently benign morphological nature, some cases of IMT have been reported to have a malignant clinical course, such as a locally aggressive growth and a tendency to recur after a complete resection (5). It is usually difficult to confirm the accurate diagnosis before operation (6, 7).…”

Inflammatory Myofibroblastic Tumor of Lung with Tuberculosis

“…Recent findings is suggestive of neoplasm because of the clonal chromosomal abnormalities. The chromosomal rearrangements involving the ALK receptor tyrosine-kinase locus region (chromosome band 2p23), or DNA aneuploidy in IMT [9,10]. In our case this chromosomal study was not done.…”