Inflammatory myofibroblastic tumor of bone harboring an ALK gene amplification

Wang, Kai; Guo, Rong–Jun; Siegal, Gene P.; Wei, Shi

doi:10.1016/j.prp.2019.152535

Cited by 6 publications

(3 citation statements)

References 50 publications

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“…Most IMTs have had good outcomes mainly due to low degree of malignant potential, low rates of recurrence and distant metastasis (2–25% with recurrence, less than 5% with metastasis), and high probability of complete surgical resection [ 4 , 32 ]. Pathologists have now found kinds of cytogenetic alterations in different cases involving ROS1, PDGFRβ, NTRK3, and RET, suggesting tumors’ malignant potential [ 36 , 37 ]. Nevertheless, the outcome of IMT is uncertain when it is related to HIV infection because there are only a few relevant case reports.…”

Section: Discussionmentioning

confidence: 99%

HIV-related bilateral inflammatory myofibroblastic tumors of the adrenal gland: a case report and literature review

et al. 2022

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Background Inflammatory myofibroblastic tumor (IMT) is a rare disease that mostly occurs in younger people and is located in the lungs in the general population. We report a rare case of adrenal IMT in a patient with HIV infection, which is believed to be the first of its kind worldwide. Case presentation We present a rare case of a 44-year-old man with HIV infection who was diagnosed with adrenal IMT. The patient refused regular highly active antiretroviral therapy 13 years ago until he was admitted to hospital after an adrenal mass was found. The patient underwent successful computed-tomography-guided needle biopsy, and pathological analysis showed fibroblastic–myofibroblastic proliferation with inflammatory infiltration, which confirmed a diagnosis of IMT. We failed to perform complete resection of the tumor because of its diffuse invasion. The patient was complicated with severe multiple pulmonary infections postoperatively because of immunodeficiency, which eventually caused his death 2 months later. Conclusion Differential diagnosis of IMT is difficult, and tumor biopsy is an essential means of diagnosis. Surgical resection is preferred for both adrenal and HIV-related IMTs. Conservative treatment should be considered when there are technical difficulties with complete resection, and most patients have achieved good outcomes. However, more cases and longer follow-up are warranted to confirm long-term outcomes of HIV-related IMT.

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Section: Discussionmentioning

confidence: 99%

HIV-related bilateral inflammatory myofibroblastic tumors of the adrenal gland: a case report and literature review

et al. 2022

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“…Most IMTs have had good outcomes as a result of factors such as demographics, comorbidities, oncological features, expression of ALK, and degree of surgical resection [4,32]. Pathologists have now demonstrated aggressive features of IMT in some cases, suggesting its malignant potential [36,37]. Nevertheless, the outcome of IMT is uncertain when it is related to HIV infection because there are only a few relevant case reports.…”

Section: Discussionmentioning

confidence: 99%

HIV-related bilateral inflammatory myofibroblastic tumors of the adrenal gland: A case report and literature review

Zhang

Liu

Zhu

et al. 2022

Preprint

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Background: Inflammatory myofibroblastic tumor (IMT) is a rare disease that mostly occurs in younger people and is located in the lungs in the general population. We report a rare case of adrenal IMT in a patient with HIV infection, which is believed to be the first of its kind worldwide.Case presentation: We present a rare case of a 44-year-old man with HIV infection who was diagnosed with adrenal IMT. The patient refused regular highly active antiretroviral therapy 13 years ago until he was admitted to hospital after an adrenal mass was found. The patient underwent successful computed-tomography-guided needle biopsy, and pathological analysis showed fibroblastic–myofibroblastic proliferation with inflammatory infiltration, which confirmed a diagnosis of IMT. We failed to perform complete resection of the tumor because of its diffuse invasion. The patient was complicated with severe multiple pulmonary infections postoperatively because of immunodeficiency, which eventually caused his death 2 months later.Conclusion: Differential diagnosis of IMT is difficult, and tumor biopsy is an important means of diagnosis. Surgical resection is preferred for both adrenal and HIV-related IMTs. Conservative treatment should be considered when there are technical difficulties with complete resection, and most patients have achieved good outcomes. However, more cases and longer follow-up are warranted to confirm long-term outcomes of HIV-related IMT.

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“…Most of IMTs had good outcomes according to the former studies, that relied on many factors such as demographics, comorbidities, oncologic features, expression of ALK, and degree of surgical completion [4,14]. Nowadays, pathologists demonstrate IMT's aggressive features of pathology in certain cases, suggesting its malignant potential [18,19]. Neverthless, the outcome of IMT is uncertain when it comes to HIV infection due to rare case reports of HIV-related IMTs.…”

Section: Discussionmentioning

confidence: 99%

A Case Report of HIV-Related Bilateral Inflammatory Myofibroblastic Tumors of Adrenal Gland

Zhang

Liu

Zhu

et al. 2021

Preprint

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Inflammatory myofibroblastic tumor (IMT) is a rare disease which mostly occurs at younger age and locates in lung in general population. We report a rare case of 44-year-old man diagnosed adrenal IMT with HIV infection, who refused regular highly active antiretroviral therapy (HAART) 13 years ago until in hospital because of findings of adrenal masses. The patient underwent CT-guided needle biopsy successfully, and the pathological analysis documented the diagnosis of IMT by the feature of proliferation of fibroblastic-myofibroblastic with inflammatory infiltration. We failed to perform tumor complete resection due to diffuse invasion of tumor under laparoscope. The patient was complicated with severely multiple pulmonary infection post to surgery because of immunodeficiency, that eventually caused the death of patient 2 months later. This case reminds us that IMTs may be too aggressive and progressed in HIV-positive patients with irregular HAART to perform surgical resections, and severe immunodeficiency can be more fatal. To our knowledge, this case is the second IMT patient with HIV infection worldwide, but the first case occurs at adrenal gland rather than lung in adult.

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Inflammatory myofibroblastic tumor of bone harboring an ALK gene amplification

Cited by 6 publications

References 50 publications

HIV-related bilateral inflammatory myofibroblastic tumors of the adrenal gland: a case report and literature review

HIV-related bilateral inflammatory myofibroblastic tumors of the adrenal gland: a case report and literature review

HIV-related bilateral inflammatory myofibroblastic tumors of the adrenal gland: A case report and literature review

A Case Report of HIV-Related Bilateral Inflammatory Myofibroblastic Tumors of Adrenal Gland

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