Inflammatory myofibroblastic tumor of lung (pseudotumor of the lung)

Mahale, Ajit; Venugopal, Anand; Acharya, Vishak; Ms, Kishore; Shanmuganathan, Aruna; Dhungel, K

doi:10.4103/0971-3026.29093

Cited by 14 publications

(5 citation statements)

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“…Mediastinal and chest wall involvement are rare. Calcification tends to occur, but is more common in children (20)(21)(22). The presence of benign features, such as homogenous enhancement, well-circumscribed lesions, and the absence of lymphadenopathy, helps to rule out lung cancer from IMFT; however, an image-guided tissue sampling is essential for a definitive diagnosis.…”

Section: Inflammatory Myofibroblastic Tumor (Imft)mentioning

confidence: 99%

Cross-sectional imaging review of common to uncommon lung cancer mimickers in a tertiary care oncology center

Patnam,

Trivedi,

Janu

et al. 2023

Acta Radiol

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Lung cancer is the most diagnosed cancer worldwide. Many non-malignant pulmonary lesions, such as tuberculosis, fungal infection, organizing pneumonia, inflammatory myofibroblastic tumor, and IgG4 disease, can mimic lung cancer due to their overlapping morphological appearance on imaging. These benign entities with minor differentiating imaging clues may go unnoticed in a high-volume cancer institution, leading to over-investigation that may result in repeated biopsies, pointless wedge resections, and related morbidities. However, with a thorough medical history, laboratory diagnostic work-up, and careful analysis of imaging findings, one can occasionally restrict the range of possible diagnoses or arrive at a definitive conclusion. When imaging features overlap, image-guided lung sampling is crucial since histopathological analysis is the gold standard.

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Section: Inflammatory Myofibroblastic Tumor (Imft)mentioning

confidence: 99%

Cross-sectional imaging review of common to uncommon lung cancer mimickers in a tertiary care oncology center

Patnam,

Trivedi,

Janu

et al. 2023

Acta Radiol

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“…Multiple infections including pulmonary tuberculosis, pseudomonas lung infection, moraxella catarrhalis, actinomycetes, mycoplasma, mycobacteria, Epstein-Barr virus and human herpes virus 8 (HHV-8) have also been reported with IPTs [10,[26][27][28][29][30][31][32][33][34][35][36][37][38][39][40].…”

Section: Association With Other Diseasesmentioning

confidence: 99%

“…On biopsy, the predominant cells seen are spindle cells. They are seen as interlacing fascicles among a polymorphous inflammatory infiltrate consisting of mature plasma cells and small lymphocytes [10,12]. Spindle cell proliferation is noted to be more marked in IMT, whereas lymphoplasmacytic infiltration is more prominent in IPTs [69].…”

Section: Associated Serum Biochemistry and Histopathologymentioning

confidence: 99%

“…They were initially recommended to reduce surrounding inflammation, particularly in CNS IMTs [9]. IMT response to steroid therapy [68,80] and steroids along with antibiotics [10], has been well-documented. One case of recurrent IPT, 11 years after steroid therapy, responded to repeat steroid therapy [25].…”

Section: Steroidsmentioning

confidence: 99%

“…IMTs are usually benign and resection achieves complete cure. However, there are times when they invade surrounding structures, undergo malignant transformation, recur [9,10] or may even metastasize [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory Myofibroblastic Tumor of the Lung

Khatri

Agrawal

Sikachi

et al. 2018

Advances in Respiratory Medicine

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Inflammatory myofibroblastic tumors (IMT) of the lung, first reported in 1939, are considered a subset of inflammatory pseudo -tumors. They are a distinctive lesions composed of myofibroblastic spindle cells accompanied by an inflammatory infiltrate of plasma cells, lymphocytes, and eosinophils. IMTs may be benign, invade surrounding structures, undergo malignant transformation, recur or may even metastasize. They can occur due to a genetic mutation or can occur secondary to infectious or autoimmune diseases. Patients may be asymptomatic, or present with cough, hemoptysis, dyspnea, pleuritic pain, constitutional symptoms or pneumonia. In this article we review the pathophysiology, genetics, clinical presentation, imaging findings of IMT of the lung. We also discuss the various surgical and non-surgical treatment options and the prognosis associated with this disease.

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