Inflammatory Myofibroblastic Tumor of Spinal Canal: Brief Case Report

Abstract

We describe a case of an intradural extramedullary inflammatory myofibroblastic tumor of the cervical spine. A 56-year-old woman presented with progressive neck pain, radiating to the right scapula, without any neurologic deficit. Magnetic resonance imaging showed an intradural extramedullary tumor with a dural tail sign, located at the C3–T1 segment with homogeneous contrast enhancement. The patient was operated on for a suspected meningioma. Pathologic examination showed fibrosis and inflammation with infiltration of B and T lymphocytes accompanied by plasmocytes, macrophages, and myofibroblast oocytes. We present the clinical course and review of the literature.

HIV-related bilateral inflammatory myofibroblastic tumors of the adrenal gland: a case report and literature review

“…IMT used to be considered a benign tumor since it was first reported in the lungs in 1939 [ 35 ]. Most IMTs have had good outcomes mainly due to low degree of malignant potential, low rates of recurrence and distant metastasis (2–25% with recurrence, less than 5% with metastasis), and high probability of complete surgical resection [ 4 , 32 ]. Pathologists have now found kinds of cytogenetic alterations in different cases involving ROS1, PDGFRβ, NTRK3, and RET, suggesting tumors’ malignant potential [ 36 , 37 ].…”

HIV-related bilateral inflammatory myofibroblastic tumors of the adrenal gland: A case report and literature review

“…IMT used to be considered a benign tumor since it was rst reported in the lungs in 1939 [35]. Most IMTs have had good outcomes as a result of factors such as demographics, comorbidities, oncological features, expression of ALK, and degree of surgical resection [4,32]. Pathologists have now demonstrated aggressive features of IMT in some cases, suggesting its malignant potential [36,37].…”

“…IMT has been referred to as in ammatory pseudotumor, pseudosarcomatous myo broblastic proliferation, in ammatory sarcoma, plasma cell granuloma, and in ammatory myohistocytic proliferation [1]. IMT mostly occurs in younger people and is located in the lungs in the general population, although other less common sites have gradually been reported in recent years, such as liver, pancreas, pharynx, spinal canal, and retroperitoneal space [1,2,3,4]. Nowadays, we are used to thinking of IMT as a low-grade malignant tumor with pathological features of proliferation of broblastic-myo broblastic cells with in ammatory in ltration, and the potential of local recurrence but a low risk of distant metastases [5].…”

A Case Report of HIV-Related Bilateral Inflammatory Myofibroblastic Tumors of Adrenal Gland

“…IMT was used to considering as benign tumor since it was rstly reported in lung in 1939 [17]. Most of IMTs had good outcomes according to the former studies, that relied on many factors such as demographics, comorbidities, oncologic features, expression of ALK, and degree of surgical completion [4,14]. Nowadays, pathologists demonstrate IMT's aggressive features of pathology in certain cases, suggesting its malignant potential [18,19].…”

“…In ammatory myo broblastic tumor (IMT) which originates from mesenchymal tissue is a very rare disease worldwide. IMT mostly occurs at younger age and locates in lung in general population, while other rare sites are gradually reported in reccent years such as liver, pancreas, pharynx, spinal canal, retroperitoneal space and so on [1,2,3,4]. Nowadays we are used to thinking of IMT as a low-grade malignant tumor with pathological feature of proliferation of broblastic-myo broblastic cells with in ammatory in ltration and a potential of local recurrence but a lower risk of distant metastases [5].…”