Inflammatory myofibroblastic tumor of the subglottis in children—Report of a single case with positive anaplastic lymphoma kinase

Gutiérrez-Jódas, José; Ruiz-Molina, Inmaculada; Jurado-Ramos, A; Navarro, José-Manuel; Ramirez-Ponferrada, R.; Solís-García, Eduardo; Baños, E. Cantillo

doi:10.1016/j.pedex.2010.08.006

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…The male-female ratio was 1.8 t0 1. They also found that the relapse rate was 21% and most of the cases in the first year after surgery [18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumor of the Larynx: Report of a Rare Case and Literature Review

Nikolaou¹,

Sakkas²,

Konstantinos³

et al. 2017

JOENTR

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Introdaction: Inflammatory myofibroblastic tumor [IMT] is a benign pseudoneoplastic proliferation which arises mainly in the lung , but extremely rarely may develop in the larynx. We report a rare case of a laryngeal IMT, mimicking a neoplastic lesion. Material and Method:A 56 years old male patient presented with a history and symptomatology typical for laryngeal carcinoma. The patient reported gradual hoarseness of the voice for 6 months and dyspnoea and stridor after effort. The patient is heavy smoker and a heavy drinker and reported nothing else significant from his medical report. Examination revealed a large mass arising from the right vocal cord, causing significant obstraction of the glottis. Results:The patient underwent microlaryngoscopy for biopsy, but complete excision of the tumor in a single specimen was performed. The intubation, operation and postop period went uneventful. The patient was discharged from the hospital the following day. Histopathologic features of the specimen were diagnostic for inflammatory myofibroblastic tumor. Follow up laryngoscopy after 8 months showed normal findings and the patient is asymptomatic. The patient remains in close follow up. Conclusion:In patients with chronic hoarseness who have a malignant looking laryngeal tumor inflammatory myofibroblastic tumor should be considered. Conservative surgery, with occasionally additional steroid treatment and close follow up of the patient, is recommended.

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“…The male-female ratio was 1.8 t0 1. They also found that the relapse rate was 21% and most of the cases in the first year after surgery [18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumor of the Larynx: Report of a Rare Case and Literature Review

Nikolaou¹,

Sakkas²,

Konstantinos³

et al. 2017

JOENTR

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“…IMT involving the larynx is rare, especially in the pediatric age group. To date, only eight cases of childhood laryngeal myofibroblastic lesions have been reported in the literature in English: four cases diagnosed as IMT and four as inflammatory pseudotumor (IPT) [ 4 - 11 ]. The mean age of these patients is 5.7 years (range of 2.5 to 10 years), and the male-to-female ratio is 7:1.…”

Section: Discussionmentioning

confidence: 99%

“…Dyspnea and stridor are the most frequently reported symptoms, whereas hoarseness (which is more common in adult laryngeal IMTs) is seen in only two cases, who are relatively older. The mean symptom duration is 3.9 months (range of 0.5 to 6 months) [ 4 - 11 ]. Most cases generally involve the subglottic region, and only one involved the vocal cord.…”

Section: Discussionmentioning

confidence: 99%

“…In the head and neck region, the paranasal sinuses and orbit are the most commonly affected areas [ 3 ]. The laryngeal presentation is extremely rare; about 30 cases have been described in the literature in English and only eight of these involved children [ 4 - 11 ]. Among these eight IMTs, there is only one case of recurrence after resection [ 7 ], demonstrating the benign clinical behavior of this tumor.…”

Section: Introductionmentioning

confidence: 99%

“…Among these eight IMTs, there is only one case of recurrence after resection [ 7 ], demonstrating the benign clinical behavior of this tumor. In addition, although anaplastic lymphoma kinase ( ALK ) gene translocation can be seen in about 50% of IMTs in young patients [ 2 , 12 ], there is only one case of childhood laryngeal IMT that reported ALK-1 positivity by immunohistochemical staining [ 4 ]. So far, there are no reports of ALK gene translocation detected at the molecular level in laryngeal IMTs.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Recurrent laryngeal inflammatory myofibroblastic tumor with positive anaplastic lymphoma kinase mimicking recurrent respiratory papillomatosis: a case report

Dong

Liu

2014

World J Surg Onc

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Inflammatory myofibroblastic tumor (IMT) of the larynx is an unusual lesion, particularly in the pediatric age group. Laryngeal IMTs in children follow a benign clinical course with reports of only rare recurrences and no metastases. Although anaplastic lymphoma kinase (ALK) has been associated with IMTs, there is only one pediatric laryngeal IMT reported to be ALK-positive with immunohistochemical staining. Here, we present a case of a 10-year-old boy with a laryngeal IMT that recurred four times and was misdiagnosed as recurrent respiratory papillomatosis after the initial three operations. ALK positivity was demonstrated by both immunohistochemical staining and fluorescence in situ hybridization. To the best of our knowledge, this case report is the first to describe a laryngeal IMT that recurred multiple times and was confirmed to be ALK-positive at the molecular level.

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Pediatric Surgical Pathology of Fibro-Inflammatory Diseases and Tumors

Alaggio

Magro

2021

Pediatric Head and Neck Textbook

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Inflammatory myofibroblastic tumor of the subglottis in children—Report of a single case with positive anaplastic lymphoma kinase

Cited by 7 publications

References 21 publications

Inflammatory Myofibroblastic Tumor of the Larynx: Report of a Rare Case and Literature Review

Inflammatory Myofibroblastic Tumor of the Larynx: Report of a Rare Case and Literature Review

Recurrent laryngeal inflammatory myofibroblastic tumor with positive anaplastic lymphoma kinase mimicking recurrent respiratory papillomatosis: a case report

Pediatric Surgical Pathology of Fibro-Inflammatory Diseases and Tumors

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