Inflammatory myofibroblastic tumor of the kidney with viral hepatitis B and trauma: A case report

Li, Zeyu; Wang, Weigang; Wang, Yuantao; Zhai, Xiuyu; Tian, Ye; Fu, Yue; Zhou, Honglan

doi:10.3892/ol.2013.1598

Cited by 17 publications

(16 citation statements)

References 14 publications

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“… 8 – 11 Trauma and chronic hepatitis B infection are also thought to play a role in tumorigenesis. 12 ALK gene rearrangement has been confirmed in some IMTs, suggesting that ALK rearrangement is correlated with tumor progression. 13 Interestingly, the patient in our report had hepatitis B infection without persistent chronic infection; also, she had a history of trauma to 2 limbs without trauma at her left waist.…”

Section: Discussionmentioning

confidence: 97%

A Renal Inflammatory Myofibroblastic Tumor Similar to Cystic Renal Cell Carcinoma

Liang

2015

Medicine

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We describe and analyze the clinical course and imaging findings of a case of a renal inflammatory myofibroblastic tumor (IMT) that is similar to cystic renal cell carcinoma.“Solitary cysts” on the left kidney were found during a health examination of a 60-year-old female. The patient also had hypertension. She had undergone surgeries twice for limb trauma fracture and had no definite record of hepatitis. There was no tenderness with percussion of the kidney area or edema in the lower extremity. The renal function results, including serum creatinine, blood urea nitrogen, and blood urea, were within the normal range. No gross hematuria or microscopic hematuria was found. An 8.7 cm × 9.2 cm mixed echogenic mass at the upper pole of the left kidney was observed with ultrasound, the majority of which was an anechoic mass that was slightly protruding from the renal capsule and had well-circumscribed borders. After a bolus injection of an ultrasound contrast agent, the mass had rapid enhancement with fast fading. An approximately 9.4 cm × 10.1 cm round-like cyst lesion at the upper pole of the left kidney was revealed by computed tomography (CT) examination of the abdomen; it had edge finishing with well-circumscribed borders. The upper inner wall of the lesion was thick with crescentic soft tissue. The solid content had gradual enhancement on enhanced CT scans. A kidney tumor was considered based on the CT findings.Based on the preoperative examination, the left renal cystic masses were resected. Intraoperative frozen sections were used to further clarify the nature of the lesion, and no significant malignant cells were observed; therefore, the kidney was not removed. The pathological diagnosis was renal IMT. After surgery, the patient recovered and did not have recurrence or metastasis over the course of long-term follow-up.CT images of our patient with renal cystic disease are categorized as Fuhrman grade IV and typically indicate the presence of malignant lesions. However, gradual enhancement of the solid content in our case is different from typical cystic renal cell carcinoma. The nature of the lesion was further identified using intraoperative frozen sections, which helped avoid unnecessary nephrectomy.

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Section: Discussionmentioning

confidence: 97%

A Renal Inflammatory Myofibroblastic Tumor Similar to Cystic Renal Cell Carcinoma

Liang

2015

Medicine

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“…Infection has been considered as a significant factor in the initiation of IMT, and several bacteria and viruses have been associated with the development of IMT, including Epstein-Barr virus, human herpes virus, Bacillus sphaericus and Mycobacterium tuberculosis (6). Recently, Li et al (7) described the case of a patient with IMT of kidney, who presented a long-term history of hepatitis B. Therefore, it can be hypothesized that hepatitis B may lead to the development of IMT.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory myofibroblastic tumor of renal pelvis presenting with iterative hematuria and abdominal pain: A case report

Zhao

et al. 2015

Oncology Letters

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Abstract. Inflammatory myofibroblastic tumor (IMT) is a rare type of mesenchymal tumor, which may affect various organs. The preferential site for IMT in the genitourinary system is the urinary bladder, while the presence of IMT in the kidney, and particularly in the renal pelvis, is rare. In the present report, the case of a 43-year-old man who was admitted to the Department of Urology of The Second Xiangya Hospital of Central South University (Changsha, China) in July 2012, with complaints of iterative gross hematuria and abdominal pain unresponsive to antibiotics is described. Computed tomography and magnetic resonance imaging indicated a slightly enhanced mass in the left renal pelvis of 1.5 cm in diameter. On request of the patient, a left nephrectomy was then performed, based on a suspected diagnosis of renal pelvic carcinoma. However, analysis of the intraoperative fast-frozen section exhibited proliferation of compact spindle cells, suggesting IMT. Therefore, further ureterectomy was avoided, and the patient remained in healthy condition thereafter.

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“…Some microbiological infections, such as mycobacteria, viral hepatitis B, Corynebacterium , Epstein-Barr virus, and human papillomavirus, may also play a potential role in the formation of IMT. [ 2 3 ] It may also be associated with the history of bladder trauma, application of steroid drugs, and placement of polypropylene mesh (TVT) surgery. [ 4 ] Third, the occurrence of IMTUB may be correlated with the overexpression of cyclin D1, mouse double microbody 2, interleukin-6, human herpesvirus 8, and p53.…”

mentioning

confidence: 99%

“…Finally, trauma, vascular causes, and autoimmune disorders have also been proposed to play a certain role. [ 3 ] In this case, recurrent urinary tract infection may represent an inciting event of IMT. However, the bladder tumor can cause obstruction of the lower urinary tract, followed by secondary infection, which shows symptoms of urinary irritation.…”

mentioning

confidence: 99%

Inflammatory Myofibroblastic Tumor of Urinary Bladder

Wang

Min

et al. 2018

Chinese Medical Journal

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Inflammatory myofibroblastic tumor of the kidney with viral hepatitis B and trauma: A case report

Cited by 17 publications

References 14 publications

A Renal Inflammatory Myofibroblastic Tumor Similar to Cystic Renal Cell Carcinoma

A Renal Inflammatory Myofibroblastic Tumor Similar to Cystic Renal Cell Carcinoma

Inflammatory myofibroblastic tumor of renal pelvis presenting with iterative hematuria and abdominal pain: A case report

Inflammatory Myofibroblastic Tumor of Urinary Bladder

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