Inflammatory Myofibroblastic Tumor of the Liver Mimicking Metastasis on 18F-FDG PET/CT

Abstract

A 62-year-old woman with history of stage III endometrial cancer was found to have a small enhancing liver lesion on follow-up abdominal CT and MRI, suspicious for metastasis. Subsequent 18F-FDG PET/CT was performed, demonstrating intense uptake within the liver lesion, consistent with metastasis. Subsequently, laparoscopic wedge liver lesion resection was performed. Histopathologic examination confirmed the diagnosis of inflammatory myofibroblastic tumor (IMT) with predominant inflammatory cells. Although solitary liver IMTs are rare occurrences with imaging features overlapping with malignancy, IMT should be considered in the differential diagnosis of suspicious liver lesions, especially when the pattern of spread is unusual.

An Interesting Case of Inflammatory Myofibroblastic Tumor Masquerading as Lymphoma Detected on 18F-FDG PET-CT

“…However, fluorine-18-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) is being increasingly used in the imaging of malignancies such as lymphoma. A limited number of studies exist that have highlighted the utility of 18F-FDG PET-CT in IMTs [ 1 , 4 - 6 ], whereas it is even rarer to find literature regarding the role of 18F-FDG PET-CT in the assessment of primary IMT of the lymph nodes [ 7 , 8 ]. Here, a case of primary IMT of the systemic lymph nodes detected on 18F-FDG PET-CT is presented.…”

Multiple Intrahepatic Inflammatory Myofibroblastic Tumor on 68Ga-FAPI and 18F-FDG PET/CT

“…Intrahepatic inflammatory myofibroblastoma tumor is one of the rare benign tumors of the liver, especially multiple inflammatory myofibroblastoma tumor in the liver, which can manifest as hypermetabolic lesion on 18 F-FDG. 1 Inflammatory myofibroblastoma tumor is a mesenchymal tumor with intermediate malignant potential, characterized by the proliferation of fibroblastic myofibroblastic cells with inflammation. 2 FAPI, a newly developed tumor imaging target, can specifically bind to FAP in vivo, which is overexpressed in cancer-associated fibroblasts in many benign and malignant diseases.…”

“…At the same time, the lesion without uptake of both radiopharmaceuticals was detected in segment VI (dotted arrow). Intrahepatic inflammatory myofibroblastoma tumor is one of the rare benign tumors of the liver, especially multiple inflammatory myofibroblastoma tumor in the liver, which can manifest as hypermetabolic lesion on 18 F-FDG 1 . Inflammatory myofibroblastoma tumor is a mesenchymal tumor with intermediate malignant potential, characterized by the proliferation of fibroblastic myofibroblastic cells with inflammation 2 .…”

Whole-Body 18F-FDG PET/CT Patlak Parametric Imaging of Hepatic Alveolar Echinococcosis

“…Hybrid FDG PET is an established imaging modality for the evaluation of malignant liver tumors but also for inflammatory diseases of the liver. [4][5][6][7][8][9][10] Recent advancements in intrinsic PET scanner sensitivity coupled with increased axial field of view coverage and advanced image reconstruction algorithms have made multibed dynamic acquisitions feasible in clinical practice. [11][12][13][14] Such acquisitions may offer complementary qualitative information and superior quantification over SUV images, through the estimation of pharmacokinetic parameter maps.…”

“…Reconstructed images, together with an aortic input function (IF), were used to generate MR FDG images (DynamicIQ; GE HealthCare), based on traditional Patlak (11 frames, full IF) and relative Patlak (7 frames, partial IF, 29 minutes from 26 minutes postinjection) analysis. Hybrid FDG PET is an established imaging modality for the evaluation of malignant liver tumors but also for inflammatory diseases of the liver 4–10 . Recent advancements in intrinsic PET scanner sensitivity coupled with increased axial field of view coverage and advanced image reconstruction algorithms have made multibed dynamic acquisitions feasible in clinical practice 11–14 .…”