Inflammatory Myofibroblastic Tumor of the Lung. A Rare Primary Lung Cancer

First report of an adult female patient with endobronchial inflammatory myofibroblastic tumor in Taiwan: A case report

“…Surgical resection is the optimal choice in the treatment of IMTs 3,6 . The operation may be performed by open thoracotomy, video‐assisted thoracoscopy surgery, or bronchoscopy.…”

“…Surgical resection is the optimal choice in the treatment of IMTs. 3 , 6 The operation may be performed by open thoracotomy, video‐assisted thoracoscopy surgery, or bronchoscopy. A frozen section or biopsy will help decide the range of excision, which is usually minimized to preserve pulmonary function.…”

“…Endobronchial IMT accounts for less than 5% of them. IMT was once thought to be a kind of inflammatory pseudotumor but it is now considered a neoplasm with myofibroblastic differentiation plus anaplastic lymphoma receptor tyrosine kinase (ALK)‐1 overexpression 3 . This implies that IMT is a neoplasm mostly driven by kinase fusion.…”

Computed tomography navigation guided transparenchymal nodule biopsy in pediatric patients with pulmonary lesions

“…Using VBN, the P-190 bronchoscope (Olympus) was guided to the target lesion and an 18G flexneedle (Broncus Medical © ) was used to create a tunnel entry point and obtain initial biopsies (Figure 1 that revealed a calcified inflammatory myofibroblastic tumor. [10][11][12] Patient 3 was an 18-year-old male with history of T-cell ALL on maintenance therapy who was referred with a 1.9 mm RUL nodule and LLL "tree-in-bud" opacities. Using VBN, the MP-190F bronchoscope (Olympus) was guided to the target lesion and a 21G periflex (Olympus) was used to create a tunnel entry point and obtain initial biopsies…”

SETD8C302R Mutation Revealed from Myofibroblastoma‐Discordant Monozygotic Twins Leads to p53/p21 Deficit and WEE1 Inhibitor Sensitivity

“…Here, in order to identify rare tumor-related genomic alterations for further functional validation and therapeutic targeting studies, we applied whole genome sequencing (WGS) on a pair of MZ twins discordant for lung inflammatory myofibroblastoma (IMT), a rare mesenchymal neoplasm that accounts for <1% of lung neoplasms. [23][24][25] Genetic screening and functional studies of candidate mutations led to a single nucleotide variation of lysine methyltransferase SETD8 (SETD8 C302R ) that resulted in dysfunctional p53/p21 pathway and increased sensitivity to WEE1 inhibition. Compared with preexisting literatures, our work integrated genome sequencing and drug sensitivity screening, which for the first time revealed the association between the rare SETD8 C302R and IMT while presenting a potential therapeutic agent for SETD8 C302R cancer cells.…”