Inflammatory Myofibroblastic Tumor of the Liver Following Renal Transplantation

Abstract

Inflammatory myofibroblastic tumor (IMT), previously named inflammatory pseudotumor, is a benign lesion, the exact etiology of which remains obscure; immunosuppression and infections have been speculated to be responsible for the development of pseudotumor. IMT associated with transplantation is rarely reported; we report the first case of IMT of the liver in a renal transplantation patient, who presented with symptoms of abdominal pain. The findings of computed tomography suggested hepatocellular carcinoma or liver abscess, and surgical resection was performed. The lesion was pathologically diagnosed as IMT.

Inflammatory myofibroblastic tumor of the esophagus treated by endoscopy

“…The etiology of these masses is poorly understood, with different theories being proposed, including immunosuppression, autoimmunity, genetic mutations, trauma, and in relation to infections such as Epstein–Barr virus (EBV), Eikenella corrodens , and HIV …”

A Rare Case of Inflammatory Myofibroblastic Tumor Causing Left Pulmonary Artery Stenosis and Successfully Treated with Localized Radiotherapy in a Patient with Perinuclear Antineutrophil Cytoplasmic Antibody Vasculitis

“…It is possible that immunosuppression contributed to the development of IMT in this patient. Cases of IMT have been reported in recipients of lung, renal, and stem cell transplants, occurring both during and after receiving intensive immunosuppressive therapy [10][11][12][13]. Harel et al posited a "two-hit hypothesis," where immunosuppression acts as an initial "hit," rendering the individual more vulnerable to subsequent events that promote IMT formation [11].…”

Combined liver transplant and pancreaticoduodenectomy for inflammatory hilar myofibroblastic tumor: Case report and review of the literature

“…The typical age of presentation is in children and young adults, but can occur at any age. The mechanism of tumor development is unknown, but theories include response to tissue injury, infection, or an autoimmune process; metastasis is uncommon.…”