Inflammatory Myofibroblastic Tumor of the Placenta

Banet, Natalie; Ning, Yi; Montgomery, Elizabeth A.

doi:10.1097/pgp.0000000000000175

Cited by 23 publications

(17 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Examination of the placenta showed no involvement by tumor in one patient, whereas details were not available for the other. Decidual-like change in inflammatory myofibroblastic tumors was previously reported by Banet et al 26 who described two cases arising in the placenta. Both tumors were confined to the placental disc and had morphologic features consistent with an inflammatory myofibroblastic tumor, although one was ALK-negative.…”

Section: Discussionsupporting

confidence: 59%

Inflammatory myofibroblastic tumor of the uterus: a clinicopathological, immunohistochemical, and molecular analysis of 13 cases highlighting their broad morphologic spectrum

et al. 2017

View full text Add to dashboard Cite

Inflammatory myofibroblastic tumors of the uterus are rare, and although most have a favorable prognosis, a small subset exhibit extrauterine disease, recur, or cause death. In this study, we evaluated the morphology and immunoprofile of 13 uterine inflammatory myofibroblastic tumors, including four with aggressive behavior. ALK rearrangements were detected by fluorescence in situ hybridization and fusion partners by anchored multiplex assay. Patients ranged from 8 to 63 (mean 39) years and tumors from 2.5 to 20 (mean 7.4) cm. Myxoid, compact, and hyalinized patterns were noted in 13, 12, and 2 tumors, ranging from 1 to 100%, 5 to 99%, and 0 to 5%, respectively. Nuclear atypia was mild in six (46%), moderate in five (38%), and severe in two (15%), with ganglion-like cells in two tumors. Mitoses ranged from 0 to 24 (mean 5) per 10 high-power fields. Inflammation was mild in five (38%), moderate in three (23%), and marked in five (38%), consisting of a lymphoplasmacytic infiltrate that was lymphocyte-predominant in six (46%). Lymphovascular invasion was noted in two (15%) and necrosis in eight (62%). All but one tumor were ALK-positive by immunohistochemistry, with granular cytoplasmic staining in nine (82%). ALK rearrangements (tested in 10) were detected in eight and was absent in one. The remaining tumor showed an isolated green 5' ALK signal. Fusion partners were identified in 10 (77%) and included THBS1 (n=3), IGFBP5 (n=2), DES (n=2), SEC31 (n=1), TPM3 (n=1), and TIMP3 (n=1). Size ≥8 cm was predictive of aggressive behavior (P<0.01), with increased mitoses (≥7 per 10 high-power fields), lymphovascular invasion, and compact-predominance approaching statistical significance. These data show that inflammatory myofibroblastic tumors of the uterus are morphologically heterogenous with frequent ALK expression and a variety of ALK fusion partners. Recognition of this rare mesenchymal neoplasm is crucial as those with aggressive behavior can potentially be treated with tyrosine kinase inhibitors.

show abstract

Section: Discussionsupporting

confidence: 59%

Inflammatory myofibroblastic tumor of the uterus: a clinicopathological, immunohistochemical, and molecular analysis of 13 cases highlighting their broad morphologic spectrum

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In this current case, the vicinity of the tumor demonstrated flat epithelial atypia in lobular units and PASH in the surrounding stroma. There are only a few case reports in the literature with ER and PR receptor expression in IMT (11,12). Banet et al (11) reported 2 IMT cases within the placenta, one of which showed patchy expression for PR receptor without ALK immunoreactivity, as well as gene rearrangement (11).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumor of the Breast Coexisting with Pseudoangiomatous Stromal Hyperplasia

Talu¹,

Çakır²,

Hacıhasanoğlu³

et al. 2016

J Breasth Health

View full text Add to dashboard Cite

IntroductionInflammatory myofibroblastic tumors (IMTs) are commonly seen in the lungs, respiratory tract, gastrointestinal system, urinary system, and deep soft tissues in children and young adults. Local recurrence is not uncommon (1). Histopathologically, the lesions consist of bundles formed by benign-looking spindle cells, accompanied by plasma cell-rich inflammatory infiltration. Depending on the density of the components forming the lesion, variants such as fasciitis-like, compact-spindle cell, and hypocellular-fibrous IMT have been described (2). IMTs were formerly thought to be reactive lesions; however, currently there is a tendency to accept them as borderline neoplasia, owing to the detection of repetitive anaplastic lymphoma kinase (ALK) gene rearrangements (1). IMT of the breast is very rare in the literature. To date, 27 cases have been reported in the literature. This lesion is especially important for ruling out differential diagnoses in breast (1, 3). Pseudoangiomatous stromal hyperplasia (PASH) is usually an incidental microscopic lesion characterized by anastomosing slit-like, non-endothelialized spaces in breast stroma (4). The common feature of IMT and PASH is that they both comprise myofibroblastic cells. Case PresentationA woman aged 38 years with a mass in her left breast was referred to our general surgery clinic. No features were determined either in her past medical history or family history. A physical examination revealed a 15-mm spherical mass with indistinct borders and high density. Ultrasonographically, the mass was solid, heterogeneous, hypoechoic, peripherally vasculated, and showed posterior enhancement (Figure 1).The core needle biopsy specimen demonstrated spindle cell proliferation with bundle formation, in which cells showing eosinophilic cytoplasm with mild nuclear atypia were seen (Figure 2a) Breast Health 2016; 12: 171-3 DOI: 10.5152/tjbh.2016.3079 171 ABSTRACTInflammatory myofibroblastic tumors (IMTs) are uncommon breast lesions that consist of spindle cells accompanied by plasma cell-rich inflammatory infiltration, which may mimic breast cancer clinico-radiologically. A woman aged 38 years with a breast mass was referred to our general surgery clinic. The physical examination revealed a mass with irregular borders in the upper outer quadrant of the left breast. In mammography, the lesion was 15 mm in diameter with a spheric form and high density. Ultrasonographically, the mass was solid, heterogeneous, and hypoechoic with posterior enhancement. Histopathologic examination of a core needle biopsy revealed a proliferation of spindle cells with eosinophilic cytoplasm and mild nuclear atypia, which showed negative immunostaining for pancytokeratin, HMWCK, CAM5.2, p63, CD34, β-catenin, and ALK but diffuse positivity for smooth muscle alpha (SMA). The lesion was reported as a "spindle cell lesion" and excision with clear margins was recommended. In the lumpectomy specimen, the lesion consisted of spindle cells that formed fascicles and infiltrated the surrounding breas...

show abstract

“…In the female genital tract, uterine‐based lesions are the most common, with tumors more often arising in the corpus than the cervix 80‐83 . Rare cases involve the placenta 84‐90 and ovary, 91 the former likely uterine in origin based on short tandem repeat genotyping 89 . Given the risk of local recurrence and rare metastasis, IMT is considered to have intermediate biological potential regardless of primary site.…”

Section: Inflammatory Myofibroblastic Tumormentioning

confidence: 99%

“…Patients may be asymptomatic or present with abnormal uterine bleeding, abdominal or pelvic pain, and/or an abdominal or pelvic mass 80‐83,92‐104 . Some cases are associated with pregnancy and are often discovered incidentally at the time of delivery within the placental disk, fetal membranes, or a mass separate from the placenta and uterus 84‐90 . Uterine IMTs have a mean size of 6.3 (range, 1‐20) cm 22,80‐83,92,94‐96,100‐102,104 .…”

Section: Inflammatory Myofibroblastic Tumormentioning

confidence: 99%

Recent advances in smooth muscle tumors with PGR and PLAG1 gene fusions and myofibroblastic uterine neoplasms

Chiang

2020

Genes Chromosomes & Cancer

View full text Add to dashboard Cite

Uterine epithelioid and myxoid leiomyosarcomas and inflammatory myofibroblastic tumors are rare mesenchymal neoplasms. Next‐generation sequencing recently detected novel PGR fusions in uterine epithelioid leiomyosarcomas that demonstrate characteristic rhabdoid and spindled morphology. PLAG1 gene fusions have also been identified in a subset of myxoid leiomyosarcomas and are associated with PLAG1 overexpression. ALK rearrangements underpin the vast majority of uterine inflammatory myofibroblastic tumors, which demonstrate morphologic, and immunohistochemical features similar to those of inflammatory myofibroblastic tumors elsewhere. This review summarizes the morphologic, immunophenotypic, and molecular genetic features of PGR fusion‐positive epithelioid leiomyosarcoma, PLAG1 fusion‐positive myxoid leiomyosarcoma, and inflammatory myofibroblastic tumors of the uterus.

show abstract

Inflammatory Myofibroblastic Tumor of the Placenta

Cited by 23 publications

References 42 publications

Inflammatory myofibroblastic tumor of the uterus: a clinicopathological, immunohistochemical, and molecular analysis of 13 cases highlighting their broad morphologic spectrum

Inflammatory myofibroblastic tumor of the uterus: a clinicopathological, immunohistochemical, and molecular analysis of 13 cases highlighting their broad morphologic spectrum

Inflammatory Myofibroblastic Tumor of the Breast Coexisting with Pseudoangiomatous Stromal Hyperplasia

Recent advances in smooth muscle tumors with PGR and PLAG1 gene fusions and myofibroblastic uterine neoplasms

Contact Info

Product

Resources

About