Inflammatory Myofibroblastic Tumors of the Kidney: A Clinicopathologic and Immunohistochemical Study of 12 Cases

Kapusta, Linda; Weiss, Mark A.; Ramsay, Jennifer; López-Beltrán, Antonio; Srigley, John R.

doi:10.1097/00000478-200305000-00009

Cited by 98 publications

(96 citation statements)

References 21 publications

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“…Studies of ALK 1 protein using immunohistochemical methods have shown positive staining in a range of 0-75% of cases, with high rates of expression in vesical IMFT (33-75%), and complete absence in IMFT of the spleen and lymph nodes. 5,11,[16][17][18] The results of our preliminary study using nine vesical IMFT support these findings, with ALK 1 protein immunocytochemically identifiable in eight vesical IMFT (89%), but negative in all 11 sarcomatoid carcinoma, leiomyosarcoma, rhabdomyosarcoma and neurofibromas examined from the bladder. Our results agree with a recent abstract that showed cytoplasmic ALK 1 staining in 12/16 (75%) IMFT, but not in 15 control cases, including leiomyosarcoma, stromal tumours and carcinosarcomas.…”

Section: Discussionsupporting

confidence: 73%

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Anaplastic lymphoma kinase (ALK 1) staining and molecular analysis in inflammatory myofibroblastic tumours of the bladder: a preliminary clinicopathological study of nine cases and review of the literature

et al. 2004

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Inflammatory myofibroblastic tumours (IMFT) may arise at any anatomical site, including lung, soft tissues, retroperitoneum and bladder. Although morphologically similar, these lesions encompass a spectrum of entities with differing aetiology, ranging from reactive/regenerative proliferations to low-grade neoplasms with a risk of local recurrence, but no significant metastatic potential. Vesical IMFT usually presents as a polypoid mass with a pale firm cut surface and can be of considerable size, mimicking a malignant tumour clinically and radiologically. Its good outcome, however, warrants conservative surgical excision, emphasising the importance of identification and distinction from malignant tumours of the bladder that may require more radical surgery and/or adjuvant therapy. We conducted a preliminary retrospective, comparative immunocytochemical study of 20 bladder tumours, including nine IMFTs, five spindle cell (sarcomatoid) carcinomas, two rhabdomyosarcomas, two leiomyosarcomas and two neurofibromas. The results confirmed IMFT positivity for smooth muscle actin, desmin and cytokeratin in 78-89% cases, resulting in potential confusion with sarcomatoid carcinoma or leiomyosarcoma. In contrast, cytoplasmic anaplastic lymphoma kinase (ALK 1) staining was present in eight IMFT (89%), but was not seen in any other lesion examined. The ALK 1 staining was confirmed by fluorescence in situ hybridisation, with translocation of the ALK gene present in 15-60% tumour cells in four of six IMFT examined, but not in four cases of sarcomatoid carcinoma or three of leiomyosarcoma. In conclusion, ALK 1 staining may be of value in the distinction of vesical IMFT from morphologically similar entities, and often reflects ALK gene translocations in these lesions.

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Section: Discussionsupporting

confidence: 73%

“…A series of studies examining the expression of ALK 1 protein expression by immunocytochemistry or ALK gene rearrangements by fluorescence in situ hybridisation (FISH) in IMFT is shown in Table 2. 5,11,[16][17][18][19] The presence of ALK gene translocations involving the 2p23 band, and the subsequent identification of ALK fusion proteins with the protein …”

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confidence: 99%

Anaplastic lymphoma kinase (ALK 1) staining and molecular analysis in inflammatory myofibroblastic tumours of the bladder: a preliminary clinicopathological study of nine cases and review of the literature

et al. 2004

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“…However, examination of the intraoperative fast-frozen section did not identify any malignancy. IMTs of renal pelvis usually display a benign disease course, with no cases of relapse or metastasis reported in the literature (11). However, malignant progression of IMTs in other anatomic sites has previously been reported (12).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory myofibroblastic tumor of renal pelvis presenting with iterative hematuria and abdominal pain: A case report

Zhao

et al. 2015

Oncology Letters

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Abstract. Inflammatory myofibroblastic tumor (IMT) is a rare type of mesenchymal tumor, which may affect various organs. The preferential site for IMT in the genitourinary system is the urinary bladder, while the presence of IMT in the kidney, and particularly in the renal pelvis, is rare. In the present report, the case of a 43-year-old man who was admitted to the Department of Urology of The Second Xiangya Hospital of Central South University (Changsha, China) in July 2012, with complaints of iterative gross hematuria and abdominal pain unresponsive to antibiotics is described. Computed tomography and magnetic resonance imaging indicated a slightly enhanced mass in the left renal pelvis of 1.5 cm in diameter. On request of the patient, a left nephrectomy was then performed, based on a suspected diagnosis of renal pelvic carcinoma. However, analysis of the intraoperative fast-frozen section exhibited proliferation of compact spindle cells, suggesting IMT. Therefore, further ureterectomy was avoided, and the patient remained in healthy condition thereafter.

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“…It was reported in retroperitoneal region [1][2][3], gastrointestinal tract, breast [4], lung [1], heart, urinary tract [5], uterus, pancreas [6].…”

Section: Introductionmentioning

confidence: 99%

Rectovaginal Septum as a Site for Recurrent Myofibroblastic Tumor (First Time Report)

Lotfi¹

2015

SOJGOW

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SOJ Gynecology, Obstetrics and Women's Health Open Access Case ReportThe outlook of this disease has changed with time from a benign reactive process to a malignant neoplasm, based on the multiple case reports demonstrating recurrent and constant clonal genetic alterations [7][8][9][10].IMT is a spindle cell proliferation that can histologically resemble various malignant mesenchymal neoplasms; however, it generally behaves as a benign or locally recurrent tumor. CaseMS is a 35 year old P1+0+0+1 who had cesarean section 6 months earlier. She presented with vaginal mass that was painless but causing difficult intercourse. She had been interviewed by general surgeon who found 8-10 cm mass related to the posterior vaginal wall. He had performed a laparotomy, trying to reach the mass through the pouch of Douglas and when he failed, he tried to have a biopsy which was insufficient and inconclusive. 3 weeks later she reported to our department, where examination showed an 8-10 cm sized mass between the rectum and posterior vaginal wall slightly shifted to the right side of the midline. The mass was not cystic but firm, mobile and not tender and extending from 2 cm above the introitus up to the level of posterior vaginal fornix. Rectal examination showed that the mass was in front of the rectum and upper part of the anal canal. A CT (Figure 1) and directed biopsy (Figure 2), was carried out and it showed 8-10 cm mass abutting the rectum but not infiltrating; the biopsy showed fibrous nature. Apart from that the patient gave no history of anything important and the examinations of all other systems were negative. She denied fever, her postpartum course had been uncomplicated and she was exclusively breast feeding since delivery. Laboratory data were unremarkable.Vaginal route exploration for excision of the mass was arranged. The posterior vaginal wall was dissected off the mass upwards the same way of doing rectocele repair. The mass was having a false capsule and this helped in its dissection from the posterior vaginal wall. To dissect the mass from the rectum and the anal canal, the assistant inserted his finger in the anal canal trying to push the mass forward and anteriorly to put it under tension to help in its dissection and in the meanwhile alarming if dissection went close to the rectum to avoid its injury (Figure 3 and Figure 4). Dissection continued and succeeded in taking the mass out ( Figure 5) and it was extending from the introitus up AbstractBackground: Myofibroblastic tumor (MT) is a neoplasm of unknown etiology, occurring at various sites but was not reported in the rectovaginal area. Literary it is composed of spindle cells (myofibroblasts). Usually it is associated with variable inflammatory component; hence the name is Inflammatory Myoblastic Tumor (IMT). The occurrence in the rectovaginal septum of female is almost unknown in the literature.

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Inflammatory Myofibroblastic Tumors of the Kidney: A Clinicopathologic and Immunohistochemical Study of 12 Cases

Cited by 98 publications

References 21 publications

Anaplastic lymphoma kinase (ALK 1) staining and molecular analysis in inflammatory myofibroblastic tumours of the bladder: a preliminary clinicopathological study of nine cases and review of the literature

Anaplastic lymphoma kinase (ALK 1) staining and molecular analysis in inflammatory myofibroblastic tumours of the bladder: a preliminary clinicopathological study of nine cases and review of the literature

Inflammatory myofibroblastic tumor of renal pelvis presenting with iterative hematuria and abdominal pain: A case report

Rectovaginal Septum as a Site for Recurrent Myofibroblastic Tumor (First Time Report)

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