Inflammatory myofibroblastic tumors

Kovach, S. J.; Fischer, Anne C.; Katzman, Philip J.; Salloum, Rabih M.; Ettinghausen, Stephen E.; Schoeniger, Luke O.; Koniaris, Leonidas G.

doi:10.1007/bf02524192

Cited by 25 publications

(49 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, this therapy may not be suitable in the present case due to the large size of the tumor surrounding large vessels, as well as due to the presence of metastatic regions. Although the number of previous reports on IMT is limited, a small number of cases have been reported (5,(12)(13)(14)(15)(16). A study reporting a case with ALK gene rearrangement-positive IMT demonstrated the failure of AI therapy followed by maintenance with imatinib subsequent to surgery (12).…”

Section: Discussionmentioning

confidence: 99%

Successful combination chemotherapy for metastatic inflammatory myofibroblastic tumor: A case report

et al. 2015

View full text Add to dashboard Cite

Abstract.A 64-year-old male presented with increased abdominal fullness and fever. Radiological examination revealed moderate ascites, a tumor with a diameter of 12.5 cm in the mesenteric region, as well as multiple tumors in the thoracic and abdominal para-aortic regions and in the left supraclavicular regions. Pathohistological findings of the biopsy specimen revealed atypical spindle cells accompanied by infiltration of lymphocytes. The plasmacytes were positive for CD68, murine double minute 2 and S-100, while they were negative for α-smooth muscle actin, cyclin-dependent kinase 4 and anaplastic lymphoma kinase. Clinically, the patient presented systemic symptoms and laboratory results indicated an elevation in the inflammatory response, while the CT and MRI findings were consistent with an inflammatory myofibroblastic tumor (IMT). Based on the clinical and histological findings, the patient was diagnosed with IMT. In total, 4 cycles of combination chemotherapy with doxorubicin and ifosfamide were administered. Tumor size reduction by 50% was achieved subsequent to the 4th chemotherapy cycle. In conclusion, successful control of this rare metastatic IMT was achieved by systemic chemotherapy. IntroductionInflammatory myofibroblastic tumor (IMT) is a relatively rare disease that predominantly occurs in the peritoneum, retroperitoneum and lungs of young people; a previous study of 38 cases reported a median age of 8.5 years (1). This disease is histologically characterized by the proliferation of various spindle cells, which are of mesenchymal cell origin, in myxoid or collagenous stroma with prominent inflammatory infiltrates (2). IMT cells can potentially behave as locally invasive and are rarely metastatic (in <5% of cases) (3). In recent studies, a chromosomal translocation involving 2p23 and subsequent anaplastic lymphoma kinase (ALK) gene rearrangement was identified in ~50% of IMT cases (3,4). The ALK inhibitor, crizotinib, was demonstrated to be an effective therapy for ALK rearrangement-positive IMT cases.Complete surgical resection is typically conducted for localized IMTs (5); however, no standard therapeutic strategy has been established for inoperable or metastatic IMTs. In the present study, an extremely rare case of metastatic IMT that responded successfully to combination chemotherapy of doxorubicin and ifosfamide was reported. Case reportA 64-year-old male presented with abdominal fullness, fever and severe fatigue in March 2014. These symptoms had worsened within half a month. Following a visit to a primary care doctor in March 2014, a computed tomography (CT) scan revealed a moderate volume of ascites and a mass in the middle of the abdomen (Fig. 1A). Initially, lymphoma was suspected, and oral prednisolone (60 mg/day) was administered for 3 days as a therapy with diagnostic intent; however, no relief of the symptoms was observed. Exploratory laparotomy indicated a protruded large tumor in the mesenterium and 2,500 ml of chylous ascites. Microscopic examination of the tumor biopsy sample was ...

show abstract

Section: Discussionmentioning

confidence: 99%

Successful combination chemotherapy for metastatic inflammatory myofibroblastic tumor: A case report

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The most commonly involved visceral site is the lung, although many extrapulmonary sites are also recognized; soft tissue localization is exceptionally rare. 2 IMT clinical manifestation and symptoms range from abdominal pain, intestinal obstruction, urinary symptoms, and a palpable mass for abdominal IMT, to mild to severe respiratory symptoms for intrapulmonary lesions.…”

Section: Discussionmentioning

confidence: 99%

A 13-Year-Old Girl with Recurrent Inguinal Lymphadenopathy

Bufalo¹,

Salfa²,

Pardi³

et al. 2014

Pediatr Ann

View full text Add to dashboard Cite

“…İnflamatuar miyofibroblastik tümörler mesane dışında akciğer, dalak, pankreas, karaciğer, kolon, meme, spermatik kord, prostat, periferal sinirler, yumuşak doku ve orbitada görülebilir [3]. Tümörün histolojik bulguları üriner sistemde ilk kez 1980 yılında, Roth tarafından 32 yaşındaki bir kadın hastada mesanede sıra dışı psödosarkomatöz olgu olarak rapor edilmiştir [1].…”

Section: Discussionunclassified

Inflammatory Myofibroblastic Tumor of the Bladder

Sarıbacak¹,

Özkan²,

Çulha³

et al. 2013

Ann Clin Anal Med

View full text Add to dashboard Cite

ÖzetMesanenin inflamatuar miyofibroblastik tümörü (İMT) nadir görülmekle birlikte embriyonel rabdomyosarkom ve leiomyosarkomdan ayrımı radikal girişimlerden kaçınılması açısından önemlidir. Bu yazıda, 32 yaşında makroskopik hematüri ile başvuran ve İMT tanısı konulan bir hastanın ilginç sistoskopik görünümü ve tedavisi sunulmuştur. Anahtar KelimelerHematüri; İnflamatuar Miyofibroblastik Tümör; Mesane AbstractInflammatory myofibroblastic tumor (IMT) of the bladder is a rare entity, its differentiation from embryonal rhabdomyosarcoma and leiomyosarcoma is essential to avoid radical interventions. We report the interesting cystoscopic appearance and treatment of an IMT case in a 32-years-old patient, presented with macroscopic hematuria.

show abstract

Inflammatory myofibroblastic tumors

Cited by 25 publications

References 0 publications

Successful combination chemotherapy for metastatic inflammatory myofibroblastic tumor: A case report

Successful combination chemotherapy for metastatic inflammatory myofibroblastic tumor: A case report

A 13-Year-Old Girl with Recurrent Inguinal Lymphadenopathy

Inflammatory Myofibroblastic Tumor of the Bladder

Contact Info

Product

Resources

About