Inflammatory myofibroblastic tumour; a case report with a unique ROS1 fusion variant

Uterine inflammatory myofibroblastic tumor: First report of a ROS1 fusion

“…Three involved exon 32 of ROS1, 13,22,24 while the location of the fourth is unknown. 21 In contrast, our IMT involved exon 34, but is predicted to behave similarly to those involving exon 32 as both the ROS1 kinase and transmembrane domains are retained at the C-terminus of the fusion protein.…”

“…Outside of the gynecologic tract, ROS1-rearranged IMTs account for approximately 10% 1,2,14 of tumors, with 37 cases reported to date. [1][2][3]9,[13][14][15][16][17][18][19][20][21][22][23][24] Most occur in the thoracic cavity (n = 14), gastrointestinal tract/liver (n = 10), or soft tissues (n = 10), with very rare (n = 8) are reported as being at least focally collagenized (hyalinized pattern), 3,13,15,17,19,24 which is a very rare morphologic feature in uterine IMTs, and only very focally present in the current case. Details regarding myogenic marker expression are limited in previous reports of ROS1-rearranged IMTs, but desmin, smooth muscle actin, and/or caldesmon appear to show variable expression.…”

“…Outside of the gynecologic tract, ROS1 ‐rearranged IMTs account for approximately 10% 1,2,14 of tumors, with 37 cases reported to date 1‐3,9,13‐24 . Most occur in the thoracic cavity (n = 14), gastrointestinal tract/liver (n = 10), or soft tissues (n = 10), with very rare examples reported in the head and neck (n = 2) or placental membranes (n = 1).…”