Inflammatory myofibroblastic tumour of the bladder: a case report and review of the literature

Marais, Bernard; Eyal, Paula; Kesner, Ken; John, Jeff

doi:10.1177/17562872221096385

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…IMT is manifested by variable and non-specific symptomatology depending on its localization. The rare cases of IMT in the urinary bladder described so far have shown that IMT can be manifested by haematuria and/or dysuric disorders [16,17], i.e., complaints that our patient also had. Fever, malaise and weight loss are often present, occurring in 15-30% of patients [18,19].…”

Section: Discussionsupporting

confidence: 55%

“…The etiology of IMT is not completely clear. It is believed that previous urinary infections, trauma, surgery or immunosuppression can play a role in the development of IMT of the urinary bladder [14,15], although there are also cases where etiological factor for the development of IMT cannot be identified [16]. In our case, the patient denies previous urinary infections, urinary tract instrumentation and surgery.…”

Section: Discussionmentioning

confidence: 67%

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Inflammatory Myofibroblastic Tumour of the Urinary Bladder in a Middle-Aged Man—A Case Report of an Unusual Localization of a Rare Tumour

Prijovic¹,

Šantrić

Babić

et al. 2023

Medicina

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Inflammatory myofibroblastic tumour (IMT) is a rare tumour with an intermediate biological behaviour. It usually occurs in children and adolescents, primarily in the abdomen or lungs. Histopathologically, IMT consists of spindle cells, i.e., myofibroblasts, and a variable inflammatory component. Localization in the urinary bladder is rare. We are presenting a rare case of IMT in the bladder in a middle-aged man treated by partial cystectomy. A 62-year-old man consulted a urologist because of haematuria and dysuric disturbances. A tumorous mass was detected by an ultrasound in the urinary bladder. CT urography described the tumorous mass at the dome of the urinary bladder measuring 2 × 5 cm. A smooth tumorous mass was cystoscopically observed at the dome of the urinary bladder. Transurethral resection of the bladder tumour was performed. Histopathological analysis of the specimen identified spindle cells with a mixed inflammatory infiltrate; immunohistochemical findings showed positivity for anaplastic lymphoma kinase (ALK), smooth muscle actin (SMA) and vimentin. A histopathological diagnosis of IMT was established. It was decided that the patient would undergo a partial cystectomy. A complete excision of the tumour from the dome of the urinary bladder with surrounding healthy tissue was performed. Histopathological and immunohistochemical findings of the sample confirmed the diagnosis of IMT, without the presence of the tumour at the surgical margins. The postoperative course went smoothly. IMT is a rare tumour in adults, especially localised in the urinary bladder. IMT of the urinary bladder is difficult to distinguish from urinary bladder malignancy both clinically and radiologically, as well as histopathologically. If the location and size of the tumour allow it, bladder-preserving surgeries such as partial cystectomy represent a reasonable modality of operative treatment.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 67%

Inflammatory Myofibroblastic Tumour of the Urinary Bladder in a Middle-Aged Man—A Case Report of an Unusual Localization of a Rare Tumour

Prijovic¹,

Šantrić

Babić

et al. 2023

Medicina

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“…Follow-up care was reported for 75 cases (87%), with mean follow up of 17.5 months (range, 2–60 months). Sixty-four patients (74%) underwent follow up cystoscopy and imaging studies, utilizing a surveillance strategy that was similar to what is used for non-muscle invasive bladder cancer ( 15 , 16 ).…”

Section: Resultsmentioning

confidence: 99%

Inflammatory myofibroblastic tumor of the genitourinary tract: a narrative review

Moring,

Swerdloff,

Htoo

et al. 2024

Transl Androl Urol

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Background and Objective Inflammatory myofibroblastic tumor (IMT) is a rare entity that is described in several organ systems. This comprehensive review aims to identify IMTs occurring at various genitourinary (GU) organ sites and describe patterns of clinical management in adult and pediatric patients. Methods A comprehensive search of PubMed and Web of Science was conducted according to the Preferred Reporting Items for Systematic Review and meta-analyses statement. Two reviewers performed independent initial screening of abstracts. Eligible articles underwent full review and data extraction. The clinical features, diagnostic tests, treatment, and outcomes at each GU organ site were analyzed individually and summarized into a comprehensive review. Key Content and Findings Of the 270 articles identified, 112 met inclusion criteria. Articles primarily consisted of case reports or small series describing a total of 167 cases, of which 30 (18%) occurred in children. Most patients (96%) were symptomatic at presentation. The most frequently involved sites included bladder (106 cases) and kidney (n=33) followed by epididymis (n=6), urachus (n=6), ureter (n=5), prostate (n=4), testis (n=4), and spermatic cord (n=3). Complete surgical excision of the mass including partial or total removal of involved organs provided excellent outcomes. Incomplete excision was associated with early local recurrence and progression. Late recurrence or metastatic transformation was rarely noted (<2%). Conclusions IMTs exhibit locally invasive, symptomatic and progressive phenotypes that affect all urologic organs in adults and children. Clinical features and imaging results are similar to those noted with urologic cancers. These tumors require complete surgical excision since incomplete resection increases the risk of symptomatic recurrence.

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“…An Inflammatory myofibroblastic tumor of urinary bladder is an uncommon benign tumor of urinary bladder of unknown neoplastic potential. Inflammatory myofibroblastic tumor of the urinary bladder 5,6 at younger age remains a diagnostic and therapeutic challenge due to its rarity and nonspecific clinical features. However, timely recognition and appropriate management, including surgical excision and adjuvant therapy, can lead to favourable outcomes with low recurrence rates.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory myofibroblastic tumor of urinary bladder in young male: A case report and literature review

Kalariya

2024

ACHR

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The objective of this study is to present a rare case of inflammatory myofibroblastic tumor (IMT) of the urinary bladder in young male, detailing its clinical presentation, diagnostic approach, treatment strategy, and outcome. Additionally, the objective includes conducting a literature review to provide insights into the characteristics, management, and prognosis of this uncommon tumor entity.A 20-year-old male presenting with dysuria and dribbling of urine underwent diagnostic workup including imaging studies, cystoscopy. On cystoscopy there was a presence of 5x4 cm sized pedunculated mass in the urinary bladder. Partial cystectomy is done and specimen is examined for histopathology. Histopathological examination and Immunohistochemistry study of the tumor specimen was performed to confirm the diagnosis of inflammatory myofibroblastic tumor. A thorough literature review was conducted to gather relevant studies on IMT of the urinary bladder, focusing on clinical presentations, diagnostic modalities, treatment approaches, and outcomes. Diagnostic evaluation revealed a mass lesion in the urinary bladder, and histopathological examination following partial cystectomy confirmed the diagnosis of inflammatory myofibroblastic tumor. The patient underwent surgical excision of the tumor followed by adjuvant therapy. Regular follow-up examinations showed no evidence of tumor recurrence. The literature review identified a limited number of reported cases of IMT of the urinary bladder in young male, emphasizing its rarity and diverse clinical presentations. Various diagnostic modalities and treatment options, including surgery, chemotherapy, and targeted therapy, were discussed in the reviewed literature. Inflammatory myofibroblastic tumor of the urinary bladder is a rare neoplasm at younger age that can present with nonspecific symptoms, making its diagnosis challenging. However, timely recognition and appropriate management, including surgical resection and adjuvant therapy, can lead to favorable outcomes with low recurrence rates. This case report highlights the importance of considering IMT in the differential diagnosis of bladder masses in young patient and underscores the need for further research to better understand the pathogenesis and optimal treatment strategies for this rare tumor entity.

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Inflammatory myofibroblastic tumour of the bladder: a case report and review of the literature

Cited by 4 publications

References 9 publications

Inflammatory Myofibroblastic Tumour of the Urinary Bladder in a Middle-Aged Man—A Case Report of an Unusual Localization of a Rare Tumour

Inflammatory Myofibroblastic Tumour of the Urinary Bladder in a Middle-Aged Man—A Case Report of an Unusual Localization of a Rare Tumour

Inflammatory myofibroblastic tumor of the genitourinary tract: a narrative review

Inflammatory myofibroblastic tumor of urinary bladder in young male: A case report and literature review

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