Inflammatory myofibroblastic tumour of the lung in a five-year-old girl

Abstract

The inflammatory myofibroblastic tumour of the lung is considered a rare diagnosis of lung masses. We report the case of a five-year-old girl who presented with recurrent pyrexia, dry cough, and shortness of breath. Chest X-ray and computed tomography showed a total atelectasis of the left lower lobe and a segmental atelectasis of the left upper lobe. The mass was removed in toto, histopathology revealed the diagnosis of an inflammatory myofibroblastic tumour of the lung. The patient is without any signs of relapse 30 months after surgery.

A rare aetiology of respiratory failure in a 10-year-old boy: inflammatory myofibroblastic tumour

“…However, patients might also be asymptomatic and the tumour may be found incidentally on imaging or direct visualisation through bronchoscopy 4. Our patient presented with symptoms of non-resolving cough and severe respiratory distress and was found to have complete atelectasis of the left lung which has been rarely reported before 10 12…”

Inflammatory Myofibroblastic Tumor of Lung with Tuberculosis

“…Several hypotheses have been proposed such as an auto-immune mechanism or infectious origin. Indeed, 30% of cases are closely related to recurrent respiratory infections which are caused by several microorganisms such as Mycoplasma, Nocardia, Actinomycetes, Epstein Barr and human herpes virus [3,4]. In the present case, the patient is a 45 year old male with history of cough and dyspnoea, with positive bronchial washings for PTB.…”

Inflammatory myofibroblastic tumours of the respiratory tract: paediatric case series with varying clinical presentations

“…1,10 Pulmonary inflammatory myofibroblastic tumours may also be identified incidentally as a mass on imaging of the thorax, or directly observed at bronchoscopy. 9,11 The three cases presented in this report demonstrate the varied ways in which inflammatory myofibroblastic tumours may present clinically. Interestingly, presentation with finger clubbing and joint problems has been documented previously.…”

“…8 Pulmonary inflammatory myofibroblastic tumours may present with respiratory symptoms due to airway obstruction or with focal chest signs; alternatively, they may not be associated with any discernible clinical features. 9 A nonspecific syndrome of chronic malaise, fever and weight loss associated with raised inflammatory markers is also a recognised presentation, as illustrated by case one. Classically, such systemic symptoms resolve following surgical resection, and may be associated with increased serum levels of the cytokine interleukin-6.…”

“…11 However, interventional bronchoscopy may potentially lead to problems with obtaining sufficient tissue for histological diagnosis and assessing resection margins. 9,11 In cases with more extensive tumour involvement, or at sites of anatomical complexity in the bronchial tree, open surgical resection and bronchial reconstruction may be required. Hoseok and colleagues recently described the case of a four-year-old boy with an inflammatory myofibroblastic tumour at the carina which extended into the left main bronchus, requiring surgical resection and carinal reconstruction.…”