Inflammatory myopathies after allogeneic stem cell transplantation

Abstract

Among recipients of allo-SCT, weakness is common, and the incidence of IM is increased. Histopathological diagnoses are varied, and we report findings of necrotizing myopathy and anti-MDA5-associated DM. Muscle Nerve, 2018.

Immune‐mediated neuromuscular complications of graft‐versus‐host disease

“…8,13 Given the common finding of muscle fiber necrosis and regeneration, GVHD-related myositis has also been anecdotally labeled as a necrotizing myopathy. 14 Our series supports this wide spectrum of histopathological findings in a single We also highlight the macrophagic-predominant infiltration, rarely reported in GVHDrelated myositis. 14,15 While historically, T-cells were considered the key player in the pathogenesis of GVHD, there is growing evidence underlining the essential role of macrophages especially in skin and lungs, and here we show similar findings in muscle.…”

“…14 Our series supports this wide spectrum of histopathological findings in a single We also highlight the macrophagic-predominant infiltration, rarely reported in GVHDrelated myositis. 14,15 While historically, T-cells were considered the key player in the pathogenesis of GVHD, there is growing evidence underlining the essential role of macrophages especially in skin and lungs, and here we show similar findings in muscle. 16 Furthermore, single nucleotide polymorphisms in genes related to the response of macrophages to bacterial antigens have been associated with susceptibility to developing GVHD.…”

“…Our series supports this wide spectrum of histopathological findings in a single series with detailed clinical and laboratory features. We also highlight the macrophagic‐predominant infiltration, rarely reported in GVHD‐related myositis 14,15 . While historically, T‐cells were considered the key player in the pathogenesis of GVHD, there is growing evidence underlining the essential role of macrophages especially in skin and lungs, and here we show similar findings in muscle 16 .…”

“…Rare cases of dermatomyositis‐like pathology have been reported with perifascular atrophy and inflammatory infiltrates 8,13 . Given the common finding of muscle fiber necrosis and regeneration, GVHD‐related myositis has also been anecdotally labeled as a necrotizing myopathy 14 . Our series supports this wide spectrum of histopathological findings in a single series with detailed clinical and laboratory features.…”

Bioinformatics analysis of gene expression profiles of Inclusion body myositis

“…GVHD can affect numerous organ systems, including muscle tissues. Furthermore, GVHD‐related inflammatory myopathy has similar clinical characteristics to autoimmune inflammatory myopathy, infiltrated by cytotoxic T cells; the prognosis of GVHD is, however, good 18 . Persistent and slow‐replicating viruses, such as retrovirus HTLV‐I, may be possible factors potentially triggering IBM's autoimmunity 19 .…”