Inflammatory pain affects alcohol intake in a dose-dependent manner in male rats in the intermittent access model

Morón, José A.

doi:10.1097/pr9.0000000000001082

PR9

2023

DOI: 10.1097/pr9.0000000000001082

|View full text |Cite

Inflammatory pain affects alcohol intake in a dose-dependent manner in male rats in the intermittent access model

José A. Morón

Abstract: Inflammatory pain does not affect alcohol intake in female rats. However, in males, pain blunts the decrease on alcohol intake when increasing the alcohol concentrations.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Preprint1

Relationship

Self Cite1

Independent0

Authors

Journals

Cited by 1 publication

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Effect of Pain in the Development of Alcohol Use Disorders: Ethanol-evoked Dopamine Release Alterations in the Rat Nucleus Accumbens

Cuitavi,

Riera-Calabuig,

Campos-Jurado

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

Purpose Alcohol use disorders (AUDs) are influenced by factors that can initiate, maintain, or induce relapse. Chronic pain has been linked to AUD as both a risk factor and a consequence of prolonged alcohol exposure. Pain share common neurological pathways with AUDs, and, in fact, alters the functioning of the mesolimbic dopaminergic system suggesting a plausible interaction. This study aims to investigate the effect of inflammatory pain on long-term alcohol intake in rats without prior alcohol consumption and observe changes in mesolimbic dopaminergic transmission. Methods Inflammatory pain was induced in eight-week-old Sprague Dawley rats using complete Freund adjuvant (CFA), while controls received saline. Two protocols were followed: one group had continuous access to 20% ethanol for one month (n = 10 per sex), and the second group for three months (n = 8 per sex) in a two-bottle choice paradigm. Mechanical nociception was assessed weekly using the Von Frey test. Dopamine levels in the nucleus accumbens core were measured through microdialysis during the final 1.5 months of ethanol exposure in the second cohort. Results After a month of alcohol exposure, rats showed no differences in alcohol consumption. However, from the second month until the end, rats exhibited a non-sex-dependent decrease in alcohol intake, significantly lower in CFA-animals. This reduction was accompanied by a blunted ethanol-evoked dopamine release in the nucleus accumbens. Conclusion These findings provide insights into the effect of pain on alcohol-elicited neurochemical responses and drinking behaviour, showing how pain alters dopamine response to alcohol, affecting drinking patterns and prolonging nociception from CFA.

show abstract

Effect of Pain in the Development of Alcohol Use Disorders: Ethanol-evoked Dopamine Release Alterations in the Rat Nucleus Accumbens

Cuitavi,

Riera-Calabuig,

Campos-Jurado

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Inflammatory pain affects alcohol intake in a dose-dependent manner in male rats in the intermittent access model

Abstract: Inflammatory pain does not affect alcohol intake in female rats. However, in males, pain blunts the decrease on alcohol intake when increasing the alcohol concentrations.

Cited by 1 publication

References 34 publications

Effect of Pain in the Development of Alcohol Use Disorders: Ethanol-evoked Dopamine Release Alterations in the Rat Nucleus Accumbens

Effect of Pain in the Development of Alcohol Use Disorders: Ethanol-evoked Dopamine Release Alterations in the Rat Nucleus Accumbens

Contact Info

Product

Resources

About