Inflammatory pathways in endometrial disorders

Maybin, Jacqueline A; Critchley, Hilary; Jabbour, Henry N.

doi:10.1016/j.mce.2010.08.006

Cited by 143 publications

(109 citation statements)

References 122 publications

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“…In situ AMPase activity, in the presence or absence of the specific inhibitor α,β-meADP, confirmed that the immunodetected protein was active in the above mentioned structures. Moreover, it is highly probable that the adenosine generated by this AMPase activity and accumulated in the stroma is involved in the regulation of cyclical inflammation physiologically occurring in endometrium [42]. Ecto-5′-nucleotidase might well act sequentially, after NTPDase1, an ecto-nucleotidase also present in the stroma.…”

Section: Discussionmentioning

confidence: 99%

Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium

Aliagas

Vidal

Torrejón‐Escribano

et al. 2012

Purinergic Signalling

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Extracellular ATP and its hydrolysis product, adenosine, acting through specific receptors collectively named purinergic receptors, regulate female fertility by influencing the endometrial fluid microenvironment. There are four major groups of ecto-nucleotidases that control the levels of extracellular ATP and adenosine and thus their availability at purinergic receptors: ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases), ecto-nucleotide pyrophosphatase/phospho-diesterases (E-NPPs), ecto-5′-nucleotidase (5′NT), and alkaline phosphatases (APs). The aim of the present work is to characterize the expression and distribution of ecto-nucleotidases in human endometrium along the menstrual cycle and after menopause, to evaluate their potential utility as fertility markers. We examined proliferative, secretory and atrophic endometria from women without endometrial pathology undergoing hysterectomy. We show that the ecto-nucleotidases are mainly present at endometrial epithelia, both luminal and glandular, and that their expression fluctuates along the cycle and also changes after menopause. An important result was identifying NPP3 as a new biological marker of tubal metaplasia. Our results emphasize the relevance of the study of purinergic signaling in human fertility.

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Section: Discussionmentioning

confidence: 99%

Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium

Aliagas

Vidal

Torrejón‐Escribano

et al. 2012

Purinergic Signalling

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“…The inflammatory nature of the disease, and the large number of genes related to the immune system/inflammation that are up-regulated in endometriosis [2] have led to the concept that factors from the immune system exacerbate the development of endometriosis instead of destroying ectopic endometrial tissue [3]- [8].…”

Section: Introductionmentioning

confidence: 99%

TNF<i>α</i> and IL1<i>β</i> Stimulate Differential Gene Expression in Endometrial Stromal Cells

Chalpe¹,

Law²,

Dumdie

et al. 2015

ABC

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The purpose of this study was to test the hypothesis that specific macrophage-secreted cytokines cause gene expression changes in endometrial stromal cells that reproduce the effects of macrophages in the development of endometriosis. Telomerase-immortalized human endometrial stromal cells (T-HESC) were treated with tumor necrosis factor α (TNFα, 5 ng/ml) and interleukin 1β (IL1β, 1 ng/ml). Differential expression of 249 genes was identified by DNA microarray. Ontologies such as peptidases, cell adhesion, cell death/cell cycle, growth factors, cytoskeletal organization, defense/immune system, signal transduction, and transcriptional regulation which are related to the development of endometriosis were represented by these genes. The up-regulation of interleukin 8 (IL8), interleukin 6 (IL6), IL1β and matrix metalloproteinase 3 (MMP3) in response to TNFα ± ILIβ in T-HESC cells was confirmed by real time RT-PCR. TNFα ± ILIβ did not affect the migration or invasion of T-HESC cells. This study reinforces our previous investigations on communication between cells of the immune system and endometrial stromal cells and their potential role in the development of endometriosis.

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“…В эндометрии имеются различные резидентные и переходные иммунные клетки, которые вместе с уникальной средой цитокинов и хемокинов играют центральную роль в нормальной функции эндоме-трия [24]. Соотношение цитокины/хемокины из-меняются в течение цикла.…”

Section: Obstetrics and Gynaecologyunclassified

“…Соотношение цитокины/хемокины из-меняются в течение цикла. Например, содержание лигандов ЛИФ, интерлейкинов (ИЛ) 1, 6, 11 и 15 и ли-гандов хемокина 2, 4, 5, 8 и 14 увеличиваются ближе к средней секреторной фазе менструального цикла [24,33]. Соотношение воспалительных и иммунных клеток изменяется на протяжении менструального цикла, причём фолликулярная фаза характеризуется преобладанием Т-клеток, а секреторная фаза -увели-ченным числом макрофагов и особенно естественных киллеров (клетки uNK) [53].…”

Section: Obstetrics and Gynaecologyunclassified

Endometrial Markers of Polycystic Ovary Syndrome (A Literature Review)

Sharifulin¹,

Шарифулин²,

Сутурина³

2018

Acta Biomedica Scientifica

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Polycystic ovary syndrome (PCOS) is the most common endocrine disease in women and has a significant impact on various aspects of their health and the quality of life. The epidemiology of PCOS is well understood, while the prevalence of this syndrome depends on diagnostic criteria used, the characteristics of the population sample, and vary from 6-10 % to 15 % and higher. A number of studies suggest that the endometrium in women with PCOS differs from the normal endometrium morphologically and functionally. PCOS is associated with infertility problems, higher incidence of pregnancy complications and with increased risk of endometrial cancer, especially when obesity is present.

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Inflammatory pathways in endometrial disorders

Cited by 143 publications

References 122 publications

Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium

Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium

TNF<i>α</i> and IL1<i>β</i> Stimulate Differential Gene Expression in Endometrial Stromal Cells

Endometrial Markers of Polycystic Ovary Syndrome (A Literature Review)

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Inflammatory pathways in endometrial disorders

Cited by 143 publications

References 122 publications

Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium

Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium

TNF&lt;i&gt;α&lt;/i&gt; and IL1&lt;i&gt;β&lt;/i&gt; Stimulate Differential Gene Expression in Endometrial Stromal Cells

Endometrial Markers of Polycystic Ovary Syndrome (A Literature Review)

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TNF<i>α</i> and IL1<i>β</i> Stimulate Differential Gene Expression in Endometrial Stromal Cells