Inflammatory Pre-Conditioning of Adipose-Derived Stem Cells with Cerebrospinal Fluid from Traumatic Brain Injury Patients Alters the Immunomodulatory Potential of ADSC Secretomes

Üçal, Muammer; Maurer, Christa; Etschmaier, Vanessa; Hamberger, Daniel; Grünbacher, Gerda; Tögl, Lennart; Roosen, Marvin J; Molcanyi, Marek; Vorholt, Daniela; Hatay, Firuze Fulya; Hescheler, Jürgen; Pallasch, Christian P.; Schäfer, Ute; Patz, Silke

doi:10.1089/neu.2020.7017

Cited by 2 publications

(2 citation statements)

References 74 publications

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“…Upon treatment with post-traumatic brain injury cerebrospinal fluid (post-TBI CSF), rendering them TBI-ADMSCs, a rise in mRNA levels of both pro-inflammatory and anti-inflammatory genes was observed. When THP1 macrophages were exposed to the secretome produced by TBI-ADMSCs, a further induction to differentiate and mature was noted, evidenced by an increased proportion of CD11b+, CD14+, and CD86+ cells alongside elevated phagocytosis activity of CD14+ and CD86+ cells [109]. However, a downregulation of both pro-and anti-inflammatory genes in macrophages was reported [109].…”

Section: The Application Of Admscs Secretome In Cns Disordersmentioning

confidence: 99%

“…When THP1 macrophages were exposed to the secretome produced by TBI-ADMSCs, a further induction to differentiate and mature was noted, evidenced by an increased proportion of CD11b+, CD14+, and CD86+ cells alongside elevated phagocytosis activity of CD14+ and CD86+ cells [109]. However, a downregulation of both pro-and anti-inflammatory genes in macrophages was reported [109]. These findings suggest that the ADMSC secretome may undergo complex alterations in pathological microenvironments, exerting diverse effects on the microenvironment concurrently.…”

Section: The Application Of Admscs Secretome In Cns Disordersmentioning

confidence: 99%

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Advanced Progress in the Role of Adipose-Derived Mesenchymal Stromal/Stem Cells in the Application of Central Nervous System Disorders

Wu,

Fan,

Zhang

2023

Pharmaceutics

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Currently, adipose-derived mesenchymal stromal/stem cells (ADMSCs) are recognized as a highly promising material for stem cell therapy due to their accessibility and safety. Given the frequently irreversible damage to neural cells associated with CNS disorders, ADMSC-related therapy, which primarily encompasses ADMSC transplantation and injection with exosomes derived from ADMSCs or secretome, has the capability to inhibit inflammatory response and neuronal apoptosis, promote neural regeneration, as well as modulate immune responses, holding potential as a comprehensive approach to treat CNS disorders and improve prognosis. Empirical evidence from both experiments and clinical trials convincingly demonstrates the satisfactory safety and efficacy of ADMSC-related therapies. This review provides a systematic summary of the role of ADMSCs in the treatment of central nervous system (CNS) disorders and explores their therapeutic potential for clinical application. ADMSC-related therapy offers a promising avenue to mitigate damage and enhance neurological function in central nervous system (CNS) disorders. However, further research is necessary to establish the safety and efficacy of clinical ADMSC-based therapy, optimize targeting accuracy, and refine delivery approaches for practical applications.

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Section: The Application Of Admscs Secretome In Cns Disordersmentioning

confidence: 99%

Section: The Application Of Admscs Secretome In Cns Disordersmentioning

confidence: 99%

Advanced Progress in the Role of Adipose-Derived Mesenchymal Stromal/Stem Cells in the Application of Central Nervous System Disorders

Wu,

Fan,

Zhang

2023

Pharmaceutics

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The therapeutic effect of adipose-derived stem cells on soft tissue injury after radiotherapy and their value for breast reconstruction

Tang

Liang

et al. 2022

Stem Cell Res Ther

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Background Postmastectomy radiotherapy is considered to be a necessary treatment in the therapy of breast cancer, while it will cause soft tissue damage and complications, which are closely related to the success rate and effectiveness of breast reconstruction. After radiotherapy, cutaneous tissue becomes thin and brittle, and its compliance decreases. Component fat grafting and adipose-derived stem cell therapy are considered to have great potential in treating radiation damage and improving skin compliance after radiotherapy. Main body In this paper, the basic types and pathological mechanisms of skin and soft tissue damage to breast skin caused by radiation therapy are described. The 2015–2021 studies related to stem cell therapy in PubMed were also reviewed. Studies suggest that adipose-derived stem cells exert their biological effects mainly through cargoes carried in extracellular vesicles and soluble secreted factors. Compared to traditional fat graft breast reconstruction, ADSC therapy amplifies the effects of stem cells in it. In order to obtain a more purposeful therapeutic effect, proper stem cell pretreatment may achieve more ideal and safe results. Conclusion Recent research works about ADSCs and other MSCs mainly focus on curative effects in the acute phase of radiation injury, and there is little research about treatment of chronic phase complications. The efficacy of stem cell therapy on alleviating skin fibrosis and its underlying mechanism require further research.

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Inflammatory Pre-Conditioning of Adipose-Derived Stem Cells with Cerebrospinal Fluid from Traumatic Brain Injury Patients Alters the Immunomodulatory Potential of ADSC Secretomes

Cited by 2 publications

References 74 publications

Advanced Progress in the Role of Adipose-Derived Mesenchymal Stromal/Stem Cells in the Application of Central Nervous System Disorders

Advanced Progress in the Role of Adipose-Derived Mesenchymal Stromal/Stem Cells in the Application of Central Nervous System Disorders

The therapeutic effect of adipose-derived stem cells on soft tissue injury after radiotherapy and their value for breast reconstruction

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