Inflammatory proteins are related to total and abdominal adiposity in a healthy adolescent population: the AVENA Study

Wärnberǵ, Julia; Nova, Esther; Moreno, Luís A.; Romeo, Javier; Mesana, M.I.; Ruiz, Jonatan R.; Ortega, Francisco B.; Sjöstróm, Michael; Bueno, Manuel; Marcos, Ascensión

doi:10.1093/ajcn/84.3.505

Cited by 138 publications

(87 citation statements)

References 42 publications

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“…The correlations found between circulating concentrations of C3 and tricipital ST, sum of STs, BMI and body fat mass as well as the associations between serum C3 and BMI, waist circumference, waist-to-height ratio and body fat (Table 3) reveal that C3 is in some way related with several adiposity markers. These findings are in accordance with previous studies reporting the association between C3 and several adiposity measurements in healthy adolescents (Warnberg et al, 2006), obese adults (Gabrielsson et al, 2003) and type 2 diabetic subjects (Kriketos et al, 2004). Anthropometrical measurements, such as BMI (Halkes et al, 2001;Ylitalo et al, 2001;Onat et al, 2005), waist circumference (Halkes et al, 2001;Onat et al, 2005) and waist-to-hip ratio (Ylitalo et al, 2001), have been considered predictors of high C3 concentrations and have been related with higher expression in visceral than in subcutaneous white adipose tissue (Gabrielsson et al, 2003).…”

Section: Discussionsupporting

confidence: 92%

“…Body mass index (BMI) was calculated according to body weight divided by squared height (kg/m 2 ). Skinfold thicknesses (STs) were measured at the right side to the nearest 0.2 mm by means of a Holtain skinfold caliper (Holtain, Crymych, UK) at the triceps, the biceps, subscapular and suprailiac (Warnberg et al, 2006). Waist and hip circumferences were measured with an inelastic tape to the nearest 1 mm.…”

Section: Anthropometry and Body Composition Measurementsmentioning

confidence: 99%

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Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults

et al. 2008

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Objectives: To evaluate the associations between serum complement factor 3 (C3) and several anthropometrical, biochemical and lifestyle features in healthy young adults, emphasizing on the putative effect of selenium intake on C3 concentrations. Methods: This study enrolled 100 healthy young adults aged 18-34 years. Anthropometric and blood pressure measurements and lifestyle features were analyzed. Fasting blood samples were collected for the measurement of glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol, triacylglycerols and C3 concentrations. Nail samples were collected for the analysis of selenium concentrations. Results: Values of BMI (P ¼ 0.034), sum of skinfold thicknesses (STs) (P ¼ 0.021), body fat mass (BFM) (P ¼ 0.023), percentage of overweight subjects (P ¼ 0.007), serum triacylglycerols (P ¼ 0.012) and nail selenium (P ¼ 0.001) were significantly different between subjects above and below the median of serum C3 concentrations. The following correlations with serum C3 were identified tricipital ST (P ¼ 0.033), sum of STs (P ¼ 0.012), BMI (P ¼ 0.008), BFM (P ¼ 0.018), waist-to-height ratio (P ¼ 0.016), serum glucose (P ¼ 0.045), serum triacylglycerols (P ¼ 0.001) and nail selenium (P ¼ 0.006). Circulating C3 showed a positive association with several adiposity markers such as BMI (P ¼ 0.001), waist circumference (P ¼ 0.006), waist-to-height ratio (P ¼ 0.002), BFM (P ¼ 0.025), as well as serum glucose (P ¼ 0.027) and triacylglycerols (Po0.001), whereas nail selenium was a statistically significant negative predictor of C3 concentrations (P ¼ 0.018). Conclusions: C3 seems to be related with selenium status and several anthropometrical and biochemical measurements linked to metabolic syndrome in apparently healthy young adults. These findings suggest a possible role for selenium intake in the modulation of C3, whose assessment may be an early marker of metabolic syndrome manifestations.

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Section: Discussionsupporting

confidence: 92%

Section: Anthropometry and Body Composition Measurementsmentioning

confidence: 99%

Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults

et al. 2008

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“…53 The finding that low-grade inflammation was significantly associated with simple anthropometric measurements is in agreement with the results from a population sample of Spanish adolescents. 3,4 However, it is noteworthy that inflammatory markers were not associated with the measures of central fatness (waist circumference, waist-to-hip ratio and waist-to-height ratio) once a measure of general fatness (BMI or skinfold thickness) was also entered in the model. Therefore, the detrimental effect of central obesity on lowgrade inflammation may be somehow mediated by general fatness in non-overweight children.…”

Section: Discussionmentioning

confidence: 99%

“…Observational studies have shown that a state of low-grade inflammation is associated with adiposity in children and adolescents, [3][4][5][6] as it has been shown in adults. 7 Low-grade inflammation is associated with anthropometric measures such as body mass index (BMI) and waist circumference in adolescents, 3,4 but data on children are sparse. Less is known about the association of low-grade inflammation with cardiovascular fitness (CVF) in prepubertal children.…”

Section: Introductionmentioning

confidence: 87%

Associations of low-grade inflammation with physical activity, fitness and fatness in prepubertal children; the European Youth Heart Study

et al. 2007

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Objective: To examine the associations of low-grade inflammation with objectively measured physical activity, cardiovascular fitness (CVF) and fatness in prepubertal children. Design: Cross-sectional study. Subjects: One hundred and forty-two children (74 boys and 68 girls) aged 9-10 years (pubertal stage I and II) from the Swedish part of the European Youth Heart Study. Measurements: Total physical activity and its intensity levels (moderate, vigorous, moderate þ vigorous) were measured by accelerometry. CVF was measured with a maximal ergometer bike test. Body fat was derived from the sum of five skinfold thicknesses. The measured low-grade inflammatory markers include C-reactive protein, fibrinogen, complement factors C3 and C4. Results: C-reactive protein and C3 were negatively associated with CVF (b ¼ À0.254 and À0.267, respectively, Po0.05) and positively associated with body fat (b ¼ 0.439 and 0.446, respectively, Po0.001), after controlling for sex, age and pubertal development. C-reactive protein and C3 were not significantly associated with CVF once body fat was in the model. Low-grade inflammation was not associated with physical activity, but physical activity was associated with CVF. Conclusions:The results showed that low-grade inflammatory markers were negatively associated with CVF and positively associated with body fat in prepubertal children. For most of the variables, the influence of fatness was slightly higher than the influence of CVF. The findings suggest that the potential beneficial effects of physical activity on low-grade inflammation may be explained by its association with CVF. Understanding the interplay between physical activity, CVF and fatness may be of importance to reducing cardiovascular disease risk in young people.

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“…Several studies with children and adolescents have demonstrated a significant association between cardiovascular risk factors and waist circumference. [23][24][25][26][27][28][29] Chronic diseases, including obesity and associated comorbidities (dyslipidemia, diabetes, hypertension, among others) have caused important harmful effects in the general population in physical, emotional, and economic terms. Thus, early identification of individuals at risk for these diseases would have great impact on the improvement of the current health situation worldwide.…”

Section: Discussionmentioning

confidence: 99%

Circunferência da cintura como indicador de gordura corporal e alterações metabólicas em adolescentes: comparação entre quatro referências

Pereira¹,

Serrano²,

Carvalho³

et al. 2010

Rev. Assoc. Med. Bras.

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Waist circumference as an indicator of body fat and metabolic disorders in adolescents: a comparison of four criteria 665Rev Assoc Med Bras 2010; 56(6): 665-9 IntroductIonObesity is defined as excessive body fat and not only overweight. 1 This disorder is increasingly prevalent and in developed countries it is the most frequent pediatric disease. 2 In Brazil, from 1974 to 1997, overweight increased from 4.1% to 13.9% in children and adolescents 3 and it is estimated that 50%-77% of this age group will also have this condition in adulthood. 2 Additionally, excessive weight in childhood and adolescence contributes to a higher incidence of morbidity and mortality from cardiovascular causes in adulthood. 4 In adolescence, excess of body fat may be associated with several important metabolic disorders, such as dyslipidemia, hypertension, and hyperinsulinemia, which characterize the metabolic syndrome. 5 This association between obesity and metabolic syndrome is even stronger if there is abdominal or central adiposity. 6 This is alarming given that abdominal obesity has been increasing more than overall obesity (assessed by body mass index) among adolescents. 7,8 Recently, there has been an increase in the waist circumference of children and adolescents in the United Kingdom 7 and Spain. 8 In British children, increased waist was higher than BMI in the last 10-20 years, especially in girls. 7 In Zaragoza, Spain, waist circumference values showed an increasing trend in adolescents aged 13 to 14 years, from 1995 to 2000-2002, and

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Inflammatory proteins are related to total and abdominal adiposity in a healthy adolescent population: the AVENA Study

Abstract: Total body fat seems to be associated with a chronic low-grade systemic inflammation in apparently healthy adolescents. Central obesity is independently associated with C3 concentrations, which makes this marker especially interesting for further studies of obesity-related diseases.

Cited by 138 publications

References 42 publications

Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults

Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults

Associations of low-grade inflammation with physical activity, fitness and fatness in prepubertal children; the European Youth Heart Study

Circunferência da cintura como indicador de gordura corporal e alterações metabólicas em adolescentes: comparação entre quatro referências

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