Inflammatory pseudo-tumor of the liver: a rare pathological entity

Abstract

Inflammatory pseudo-tumor (IPT) of the liver is a rare benign neoplasm and is often mistaken as a malignant entity. Few cases have been reported in the literature and the precise etiology of inflammatory pseudotumor remains unknown. Patients usually present with fever, abdominal pain and jaundice. The proliferation of spindled myofibroblast cells mixed with variable amounts of reactive inflammatory cells is characteristics of IPT. We reviewed the literature regarding possible etiology for IPT with a possible suggested etiology.

Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis: A case report

“…Most IMTs occur in the lungs and airways of young patients. However, other organs, including mesentery, omentum, stomach, small intestine, large intestine, mediastinum, retroperitoneum, liver and bladder, have been documented (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Among these extrapulmonary IMTs, 43% arise in the mesentery and omentum (29).…”

“…IMT used to be considered as an inflammatory pseudotumor, xanthogranuloma, plasma-cell granuloma, plasma-cell pseudotumor or an inflammatory myofibroblastic tumor. IMT commonly occurs in the lung, mesentery, omentum and retroperitoneum, but it may also be observed in the extremities, head and neck region, liver, spleen, thyroid, gastrointestinal tract, genitourinary tract and other systems (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). The tumors usually follow a benign course, but recurrences have been documented in up to 25% of cases.…”

Inflammatory pseudotumor of the liver: A case report and literature review

“…IPT most commonly occurs in the lung, but it can be found in other locations including the central nervous system, major salivary glands, the kidneys, the liver, the omentum, the ovaries, the larynx, the urinary bladder, the breasts, the pancreas, the spleen, lymph nodes, skin, soft tissues, and the orbit of the eye (2). An IPT of the liver (IPTL) is a rare benign lesion characterized by chronic infiltration of inflammatory cells and an area of fibrosis that sometimes mimics a malignant tumor (3,4). An IPTL was first reported by Pack and Baker in 1953 (5).…”

A Liver Inflammatory Pseudotumor Misdiagnosed as Liver Cancer Using Noninvasive Diagnostic Methods

“…Inflammatory pseudotumor (IPT) is a rare benign tumor, and most often occurs in the lung [1,2], followed in frequency by the liver [3]. Liver IPT is a tumor-like lesion, formed by the infiltration of inflammatory cells under the influence of various pro-inflammatory cytokines in liver tissue and hyperplasia of fibrous tissue.…”

“…Liver IPT is a tumor-like lesion, formed by the infiltration of inflammatory cells under the influence of various pro-inflammatory cytokines in liver tissue and hyperplasia of fibrous tissue. IPT is often difficult to differentiate from malignant liver tumors because of the lack of specific IPT symptoms and imaging findings [1,2]. Liver IPT has become detectable because of ongoing advances in imaging technology and new progress in the diagnosis of liver tumors [3].…”