2001
DOI: 10.1097/00000478-200106000-00003
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Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor

Abstract: Follicular dendritic cell (FDC) tumors are uncommon neoplasms that can involve lymph nodes or extranodal sites. They can exhibit a broad spectrum of histologic appearances and behavior, but the intra-abdominal ones usually pursue an aggressive course. The purpose of this study was to characterize a distinctive variant of FDC tumor morphologically mimicking inflammatory pseudotumor through analysis of the clinicopathologic features of 11 cases. The patients included 10 women and one man (age range, 19-61 years;… Show more

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Cited by 275 publications
(119 citation statements)
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“…8 Most FDCTs arising at the liver or spleen are categorized as IPT-like FDCTs, and this type is rare at other sites. 4 IPT-like FDCTs arising at the liver or spleen are associated with EBV infection, whereas conventional FDC tumors show EBV association in only one of 25 cases (4%). [3][4][5] Thus, the identification of EBV infection is important in the diagnosis of IPT-like FDCTs by immunostaining for EBV-LMP, which is a protein product of EBV with transforming function, or by the detection of the EBER gene by in situ hybridization.…”
Section: Discussionmentioning
confidence: 97%
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“…8 Most FDCTs arising at the liver or spleen are categorized as IPT-like FDCTs, and this type is rare at other sites. 4 IPT-like FDCTs arising at the liver or spleen are associated with EBV infection, whereas conventional FDC tumors show EBV association in only one of 25 cases (4%). [3][4][5] Thus, the identification of EBV infection is important in the diagnosis of IPT-like FDCTs by immunostaining for EBV-LMP, which is a protein product of EBV with transforming function, or by the detection of the EBER gene by in situ hybridization.…”
Section: Discussionmentioning
confidence: 97%
“…Histologically, FDCTs are characterized by the syncytial growth of spindle or ovoid cells, which are immunoreactive for such various FDC markers as CD21 and CD35. 4 A storiform or whorled growth pattern is frequently encountered. FDCTs are categorized into 2 types-conventional FDCTs composed of the storiform, fascicular, and diffuse growth of tumor cells with a sprinkling of lymphocytes and IPT-like FDCTs composed of dispersed tumor cells with intense lymphocytes and plasma cells.…”
Section: Discussionmentioning
confidence: 99%
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